Journal ArticleDOI
Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Kiril Trpkov,Sean R. Williamson,Anthony J. Gill,Adebowale J. Adeniran,Abbas Agaimy,Reza Alaghehbandan,Mahul B. Amin,Pedram Argani,Ying-Bei Chen,Liang Cheng,Jonathan I. Epstein,John C. Cheville,Eva Comperat,Isabela Werneck da Cunha,Jennifer B. Gordetsky,Sounak Gupta,Huiying He,Michelle S. Hirsch,Peter A. Humphrey,Payal Kapur,Fumiyoshi Kojima,José I. López,Fiona Maclean,Cristina Magi-Galluzzi,Jesse K. McKenney,Rohit Mehra,Santosh Menon,George J. Netto,Christopher G. Przybycin,Priya Rao,Qiu Rao,Victor E. Reuter,Rola Saleeb,Rajal B. Shah,Steven C. Smith,Satish K. Tickoo,Maria S. Tretiakova,Lawrence D. True,Virginie Verkarre,Sara E. Wobker,Ming Zhou,Ondrej Hes +41 more
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TLDR
In this paper, a review of the recent advances in renal neoplasia, particularly focusing on the newly accumulated evidence post-2016 World Health Organization (WHO) classification is presented.About:
This article is published in Modern Pathology.The article was published on 2021-02-01. It has received 106 citations till now.read more
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The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Holger Moch,Mahul B. Amin,Daniel M. Berney,Eva Comperat,Anthony J. Gill,Arndt Hartmann,Santosh Menon,Maria Rosaria Raspollini,Mark A. Rubin,John R. Srigley,Puay Hoon Tan,Satish K. Tickoo,Toyonori Tsuzuki,Samra Turajlic,Ian A. Cree,George J. Netto +15 more
TL;DR: The fifth edition of the World Health Organization (WHO) classification of urogenital tumours (Blue Book), published in 2022, contains significant revisions for renal, penile, and testicular tumours as mentioned in this paper .
Journal ArticleDOI
Low-Grade Oncocytic Tumor of Kidney (CK7-Positive, CD117-Negative): Incidence in a Single Institutional Experience with Clinicopathological and Molecular Characteristics.
Oleksandr Kravtsov,Sounak Gupta,John C. Cheville,William R. Sukov,Ross A. Rowsey,Loren Herrera-Hernandez,Christine M. Lohse,Ryan A. Knudson,Bradley C. Leibovich,Rafael E. Jimenez +9 more
TL;DR: In this paper, low-grade oncocytic tumor of the kidney (LOT) is characterized by cytoplasmic eosinophilia and a CK7-positive/CD117-negative immunophenotype.
Journal ArticleDOI
Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases
TL;DR: The eosinophilic vacuolated tumor (EVT) as discussed by the authors represents an emerging renal entity that shows a characteristic and readily identifiable morphology, consistent immunohistochemical profile, indolent behavior, and mutations in either TSC1, TSC2, or MTOR genes.
Journal ArticleDOI
Co-existence of ESC-RCC, EVT, and LOT as synchronous and metachronous tumors in six patients with multifocal neoplasia but without clinical features of tuberous sclerosis complex.
TL;DR: In this article, the authors described multifocal, often bilateral, tumors in six patients without personal or family history of syndromic diseases and provided evidence of co-existence in the same organ and unequivocal relatedness of ESC-RCC, EVT, and LOT.
Journal ArticleDOI
Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney.
Payal Kapur,Payal Kapur,Ming Gao,Joanna Zawiejska-Rataj,Hua Zhong,Suneetha Chintalapati,Midori Mitui,Spencer D. Barnes,Qinbo Zhou,Jeffrey Miyata,Deyssy Carrillo,Venkat S. Malladi,Dinesh Rakheja,Ivan Pedrosa,Lin Xu,Lisa N. Kinch,James Brugarolas +16 more
TL;DR: In this article, the authors describe 22 low-grade oncocytic tumor (LOT) cases corresponding to 7 patients presenting with a median age of 75 years (range 63-86 years) and male to female ratio 2:5.
References
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mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
Caleb F. Davis,Christopher J. Ricketts,Min Wang,Lixing Yang,Andrew D. Cherniack,Hui Shen,Christian J. Buhay,Hyojin Kang,Sang Cheol Kim,Catherine C. Fahey,Kathryn E. Hacker,Gyan Bhanot,Dmitry A. Gordenin,Andy Chu,Preethi H. Gunaratne,Preethi H. Gunaratne,Michael Biehl,Sahil Seth,Benny Abraham Kaipparettu,Christopher A. Bristow,Lawrence A. Donehower,Eric Wallen,Angela B. Smith,Satish K. Tickoo,Pheroze Tamboli,Victor E. Reuter,Laura S. Schmidt,James J. Hsieh,James J. Hsieh,Toni K. Choueiri,A. Ari Hakimi,Chad J. Creighton,Margaret Morgan,David A. Wheeler,Richard A. Gibbs,Sabina Signoretti,A. Gordon Robertson,Elizabeth P. Henske,David J. Kwiatkowski,Christopher J. Ricketts,W. Marston Linehan,Michael P. Seiler,W. Kimryn Rathmell,Peter W. Laird,Brian Shuch,Donna M. Muzny,Hsu Chao,Mike Dahdouli,Liu Xi,Nipun Kakkar,Jeffrey G. Reid,Brittany Downs,Jennifer Drummond,Donna Morton,Harsha Doddapaneni,Lora Lewis,Adam C. English,Qingchang Meng,Christie Kovar,Qiaoyan Wang,Walker Hale,Alicia Hawes,Divya Kalra,Kimberly Walker,Bradley A. Murray,Carrie Sougnez,Gordon Saksena,Scott L. Carter,Steven E. Schumacher,Barbara Tabak,Travis I. Zack,Gad Getz,Rameen Beroukhim,Stacey Gabriel,Matthew Meyerson,Adrian Ally,Miruna Balasundaram,Inanc Birol,Denise Brooks,Yaron S.N. Butterfield,Eric Chuah,Amanda Clarke,Noreen Dhalla,Ranabir Guin,Robert A. Holt,Katayoon Kasaian,Darlene Lee,Haiyan I. Li,Emilia L. Lim,Yussanne Ma,Michael Mayo,Richard A. Moore,Andrew J. Mungall,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Tina Wong,Steven J.M. Jones,Marco A. Marra,J. Todd Auman,Donghui Tan,Shaowu Meng,Corbin D. Jones,Katherine A. Hoadley,Piotr A. Mieczkowski,Lisle E. Mose,Stuart R. Jefferys,Jeffrey Roach,Umadevi Veluvolu,Matthew D. Wilkerson,Scot Waring,Elizabeth Buda,Junyuan Wu,Tom Bodenheimer,Alan P. Hoyle,Janae V. Simons,Mathew G. Soloway,Saianand Balu,Joel S. Parker,D. Neil Hayes,Charles M. Perou,Daniel J. Weisenberger,Moiz S. Bootwalla,Timothy J. Triche,Phillip H. Lai,David Van Den Berg,Stephen B. Baylin,Fengju Chen,Cristian Coarfa,Michael S. Noble,Daniel DiCara,Hailei Zhang,Juok Cho,David I. Heiman,Nils Gehlenborg,Doug Voet,Pei Lin,Scott Frazer,Petar Stojanov,Yingchun Liu,Lihua Zou,Jaegil Kim,Michael S. Lawrence,Lynda Chin,Alexei Protopopov,Xingzhi Song,Jianhua Zhang,Angeliki Pantazi,Angela Hadjipanayis,Eunjung Lee,Lovelace J. Luquette,Semin Lee,Michael Parfenov,Netty Santoso,Jonathan G. Seidman,Andrew Wei Xu,Raju Kucherlapati,Peter J. Park,Junehawk Lee,Steven A. Roberts,Leszek J. Klimczak,David C. Fargo,Martin Lang,Yoon-La Choi,June Koo Lee,Woong-Yang Park,Wenyi Wang,Yu Fan,Jaeil Ahn,Rehan Akbani,John N. Weinstein,David Haussler,Singer Ma,Amie Radenbaugh,Jingchun Zhul,Tara M. Lichtenberg,Erik Zmuda,Aaron D. Black,Benjamin Hanf,Nilsa C. Ramirez,Lisa Wise,Jay Bowen,Kristen M. Leraas,Tracy M. Hall,Julie M. Gastier-Foster,William G. Kaelin,Leigh B. Thorne,Lori Boice,Mei Huang,Cathy D. Vocke,James Peterson,Robert Worrell,Maria J. Merino,Bogdan Czerniak,Kenneth Aldape,Christopher G. Wood,Paul T. Spellman,Michael B. Atkins,John C. Cheville,R. Houston Thompson,Mark A. Jensen,Todd Pihl,Yunhu Wan,Brenda Ayala,Julien Baboud,Sudhakar Velaga,Jessica Walton,Jia Liu,Sudha Chudamani,Ye Wu,Margi Sheth,Kenna R. Mills Shaw,John A. Demchok,Tanja M. Davidsen,Liming Yang,Zhining Wang,Roy Tarnuzzer,Jiashan Zhang,Greg Eley,Ina Felau,Jean C. Zenklusen,Carolyn M. Hutter,Mark S. Guyer,Bradley A. Ozenberger,Heidi J. Sofia +225 more
TL;DR: Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT upregulation in cancer distinct from previously observed amplifications and point mutations.
Journal ArticleDOI
Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
Bengt Hallberg,Ruth H. Palmer +1 more
TL;DR: The current understanding of ALK function in human cancer and the implications for tumour treatment are discussed.
Journal ArticleDOI
Tuberous sclerosis-associated renal cell carcinoma: a clinicopathologic study of 57 separate carcinomas in 18 patients.
Juan Guo,Maria S. Tretiakova,Megan L. Troxell,Adeboye O. Osunkoya,Oluwole Fadare,Ankur R. Sangoi,Steven S. Shen,Antonio Lopez-Beltran,Rohit Mehra,Amer Heider,John P. Higgins,Lara Harik,Xavier Leroy,Anthony J. Gill,Kiril Trpkov,Steven C. Campbell,Christopher G. Przybycin,Christopher G. Przybycin,Cristina Magi-Galluzzi,Cristina Magi-Galluzzi,Jesse K. McKenney,Jesse K. McKenney +21 more
TL;DR: Tuberous sclerosis complex-associated RCCs have unique clinicopathologic features including female predominance, younger age at diagnosis, multiplicity, association with AMLs, 3 recurring histologic patterns, and an indolent clinical course.
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