Novel insights into the genetic and epigenetic paternal contribution to the human embryo
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TLDR
The health of the sperm genome and epigenome is critical for improving assisted conception rates and the birth of healthy offspring.About:
This article is published in Clinics.The article was published on 2013-01-01 and is currently open access. It has received 102 citations till now. The article focuses on the topics: Epigenome & Sperm.read more
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A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line
TL;DR: This essay suggests the existence of epigenetic windows of susceptibility to environmental insults during sperm development and suggests changes in DNA methylation, histone modification, and non‐coding RNAs are viable mechanistic candidates for a non‐genetic transfer of paternal environmental information, from maturing germ cell to zygote.
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Epigenetics and its role in male infertility
TL;DR: This review provides an overview of the epigenetic processes (histone-to-protamine exchange and epigenetic reprogramming post-fertilization), aberrant epigeneticReprogramming and its association with fertility, possible risks for ART techniques, testicular cancer and the effect of environmental factors on the epigenetics processes.
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What is a paternal effect
TL;DR: Three basic types of paternal effect are distinguished and key questions that can serve as a road map for research on the proximate basis and evolutionary implications of paternal effects are outlined.
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Intracytoplasmic sperm injection for male infertility and consequences for offspring
Sandro C. Esteves,Sandro C. Esteves,Matheus Roque,Giuliano Bedoschi,Thor Haahr,Peter Humaidan +5 more
TL;DR: Existing evidence does not support ICSI in preference over in vitro fertilization (IVF) in the general non-male factor ART population; however, in couples with unexplained infertility, I CSI is associated with lower fertilization failure rates than IVF.
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Clinical management of infertile men with nonobstructive azoospermia.
TL;DR: A five-consecutive-step algorithm is proposed to manage men with nonobstructive azoospermia seeking fertility, including the lessons learned over 15 years dealing with this male infertility condition.
References
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Epigenetic Reprogramming in Mammalian Development
Wolf Reik,Wendy Dean,Jörn Walter +2 more
TL;DR: What is known about reprogramming in mammals and how it might relate to developmental potency and imprinting are discussed, including whether or not methylation is involved in the control of gene expression during normal development.
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Dnmt3L and the establishment of maternal genomic imprints.
TL;DR: Bisulfite genomic sequencing of DNA from oocytes and embryos showed that removal of Dnmt3L prevented methylation of sequences that are normally maternally methylated, and the defect was specific to imprinted regions, and global genome methylation levels were not affected.
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Distinctive chromatin in human sperm packages genes for embryo development
Saher Sue Hammoud,David A. Nix,Haiying Zhang,Jahnvi Purwar,Douglas T. Carrell,Bradley R. Cairns +5 more
TL;DR: It is shown that the retained nucleosomes are significantly enriched at loci of developmental importance, including imprinted gene clusters, microRNA clusters, HOX genes clusters, and the promoters of stand-alone developmental transcription and signalling factors.
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Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice
TL;DR: It is demonstrated that Dnmt3L, a protein sharing homology with DNA methyltransferases, but lacking enzymatic activity, is essential for the establishment of maternal methylation imprints and appropriate expression of maternally imprinted genes.
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RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse
Minoo Rassoulzadegan,Minoo Rassoulzadegan,Valérie Grandjean,Valérie Grandjean,Pierre Gounon,Stéphane D. Vincent,Stéphane D. Vincent,Stéphane D. Vincent,Isabelle Gillot,Isabelle Gillot,François Cuzin,François Cuzin +11 more
TL;DR: This work reports a similar modification of the mouse Kit gene in the progeny of heterozygotes with the null mutant Kittm1Alf (a lacZ insertion), identifying an unexpected mode of epigenetic inheritance associated with the zygotic transfer of RNA molecules.