Journal ArticleDOI
Novel Pachymetric Parameters Based on Corneal Tomography for Diagnosing Keratoconus
Renato Ambrósio,Ana Laura C. Caiado,Frederico P. Guerra,Ricardo N Louzada,Abhijit Sinha Roy,Allan Luz,William J. Dupps,Michael W. Belin +7 more
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TLDR
Tomographic-derived pachymetric parameters were better able to differentiate normal and keratoconic corneas than single-point pachymetry measurements and the role of tomography in identifying early forms of ectasia as well as ectasia risk among LASIK candidates is needed.Abstract:
PURPOSE: To describe pachymetric progression indices (PPI) of the Pentacam HR (Oculus Optikgerate) and the concept of relational thickness, and to test their accuracy for differentiating keratoconic and normal corneas compared with single-point thickness values.read more
Citations
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Journal ArticleDOI
Global consensus on keratoconus and ectatic diseases.
José Álvaro Pereira Gomes,Donald T.H. Tan,Christopher J. Rapuano,Michael W. Belin,Renato Ambrósio,José L. Güell,François Malecaze,Kohji Nishida,Virender S Sangwan +8 more
TL;DR: This project reached consensus of ophthalmology experts from around the world regarding keratoconus and ectatic diseases, focusing on their definition, concepts, clinical management, and surgical treatments, and provides an insight into the current worldwide treatment of these conditions.
Journal ArticleDOI
Use of a support vector machine for keratoconus and subclinical keratoconus detection by topographic and tomographic data
TL;DR: The classification algorithm showed high accuracy, precision, sensitivity, and specificity in discriminating among abnormal eyes, eyes with keratoconus or subclinical keratconus, and normal eyes and may be particularly useful in excluding eyes with early signs of corneal ectasia when screening patients for excimer laser surgery.
Journal ArticleDOI
Characterization of corneal structure in keratoconus
TL;DR: Ophthalmic devices for corneal analysis and diagnosis have experienced a rapid development during the past decade with the implementation of technologies such as scanning-slit topography, Scheimpflug photography, and optical coherence tomography, which are able to accurately describe not only the geometry of the anterior Corneal surface but also that of the posterior surface.
Journal ArticleDOI
Assessing progression of keratoconus: novel tomographic determinants
TL;DR: How modern corneal tomography, including both anterior and posterior elevation and pachymetric data can be used to screen for ectatic progression, and how software programs such as the Enhanced Reference Surface and the Belin-Ambrosio Enhanced Ectasia Display can be employed to detect earlier changes are described.
Journal ArticleDOI
Keratoconus management: long-term stability of topography-guided normalization combined with high-fluence CXL stabilization (the Athens Protocol).
TL;DR: The Athens Protocol to arrest keratectasia progression and improve corneal regularity demonstrates safe and effective results as a keratoconus management option.
References
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Journal ArticleDOI
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
TL;DR: A representation and interpretation of the area under a receiver operating characteristic (ROC) curve obtained by the "rating" method, or by mathematical predictions based on patient characteristics, is presented and it is shown that in such a setting the area represents the probability that a randomly chosen diseased subject is (correctly) rated or ranked with greater suspicion than a random chosen non-diseased subject.
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Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.
TL;DR: A nonparametric approach to the analysis of areas under correlated ROC curves is presented, by using the theory on generalized U-statistics to generate an estimated covariance matrix.
Journal Article
A relational model of data for large shared data banks. 1970
TL;DR: A model based on n-ary relations, a normal form for data base relations, and the concept of a universal data sublanguage are introduced and certain operations on relations are discussed and applied to the problems of redundancy and consistency in the user's model.
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Risk assessment for ectasia after corneal refractive surgery.
TL;DR: A quantitative method can be used to identify eyes at risk for developing ectasia after LASIK that, if validated, represents a significant improvement over current screening strategies.
Journal ArticleDOI
Statistical Approaches to the Analysis of Receiver Operating Characteristic (ROC) Curves
TL;DR: This article shows how to calculate confidence limits around any point on the curve and shows, using the conventional Dorfman and Alf program and the jackknifing technique, how to calculated these confidence limits for multiple curves derived from the same sample of patients.