Novel U-bent fiber optic probe for localized surface plasmon resonance based biosensor.
TL;DR: A sensor for sensitive measurement of refractive index (RI) with the help of optical absorbance properties of gold nanoparticles (GNP) coupled to an efficient optical transducer in the form of a U-bent fiber optic probe is described.
About: This article is published in Biosensors and Bioelectronics.The article was published on 2009-05-15. It has received 261 citations till now. The article focuses on the topics: Surface plasmon resonance & Surface plasmon.
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TL;DR: A wide range of new lead finding and lead optimization opportunities result from novel screening methods by NMR, which are the topic of this review article.
Abstract: In recent years, tools for the development of new drugs have been dramatically improved. These include genomic and proteomic research, numerous biophysical methods, combinatorial chemistry and screening technologies. In addition, early ADMET studies are employed in order to significantly reduce the failure rate in the development of drug candidates. As a consequence, the lead finding, lead optimization and development process has gained marked enhancement in speed and efficiency. In parallel to this development, major pharma companies are increasingly outsourcing many components of drug discovery research to biotech companies. All these measures are designed to address the need for a faster time to market. New screening methodologies have contributed significantly to the efficiency of the drug discovery process. The conventional screening of single compounds or compound libraries has been dramatically accelerated by high throughput screening methods. In addition, in silico screening methods allow the evaluation of virtual compounds. A wide range of new lead finding and lead optimization opportunities result from novel screening methods by NMR, which are the topic of this review article.
803 citations
TL;DR: A detailed review of the key underpinning science for such systems and of recent progress in the development of a number of LSPR-based biosensors which use gold nanorods as the active element is provided in this paper.
Abstract: Noble metal nanoparticle-based localized surface plasmon resonance (LSPR) is an advanced and powerful label-free biosensing technique which is well-known for its high sensitivity to the surrounding refractive index change in the local environment caused by the biomolecular interactions around the sensing area. The characteristics of the LSPR effect in such sensors are highly dependent on the size, shape and nature of the material properties of the metallic nanoparticles considered. Among the various types of metallic nanoparticles used in studies employing the LSPR technique, the use of gold nanorods (GNRs) has attracted particular attention for the development of sensitive LSPR biosensors, this arising from the unique and intriguing optical properties of the material. This paper provides a detailed review of the key underpinning science for such systems and of recent progress in the development of a number of LSPR-based biosensors which use GNR as the active element, including an overview of the sensing principle, the synthesis of GNRs, the fabrication of a number of biosensors, techniques for surface modification of GNRs and finally their performance in several biosensing applications. The review ends with a consideration of key advances in GNR-based LSPR sensing and prospects for future research and advances for the development of the GNR-based LSPR biosensors.
576 citations
TL;DR: An overview of the technologies used to implement surface plasmon resonance (SPR) effects into fiber-optic sensors for chemical and biochemical applications and a survey of results reported over the last ten years is presented.
Abstract: This paper presents a brief overview of the technologies used to implement surface plasmon resonance (SPR) effects into fiber-optic sensors for chemical and biochemical applications and a survey of results reported over the last ten years. The performance indicators that are relevant for such systems, such as refractometric sensitivity, operating wavelength, and figure of merit (FOM), are discussed and listed in table form. A list of experimental results with reported limits of detection (LOD) for proteins, toxins, viruses, DNA, bacteria, glucose, and various chemicals is also provided for the same time period. Configurations discussed include fiber-optic analogues of the Kretschmann–Raether prism SPR platforms, made from geometry-modified multimode and single-mode optical fibers (unclad, side-polished, tapered, and U-shaped), long period fiber gratings (LPFG), tilted fiber Bragg gratings (TFBG), and specialty fibers (plastic or polymer, microstructured, and photonic crystal fibers). Configurations involving the excitation of surface plasmon polaritons (SPP) on continuous thin metal layers as well as those involving localized SPR (LSPR) phenomena in nanoparticle metal coatings of gold, silver, and other metals at visible and near-infrared wavelengths are described and compared quantitatively.
555 citations
Cites methods from "Novel U-bent fiber optic probe for ..."
...The example reported here uses NPs for LSPR generation [37]....
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22 Nov 2016
TL;DR: Examples of applications of optical affinity biosensors based on plasmonic nanostructures for both the detection of chemical and biological substances as well as the investigation of biomolecular interactions are given.
Abstract: This paper reviews fundamentals of optical affinity biosensors based on plasmonic nanostructures and discusses recent advances in the development of this technology, including plasmonic nanostructures and surface plasmon phenomena, advances in sensor instrumentation, and functional coatings. Examples of applications for both the detection of chemical and biological substances as well as the investigation of biomolecular interactions are also given.
293 citations
Cites background or methods from "Novel U-bent fiber optic probe for ..."
...A simple configuration consisting of a nanoparticle-based U-bent fiber, LED, and fiber-coupled spectrometer [35] was recently shown to exhibit better performance when compared to a colinear transmission-based system [13] of comparable configuration....
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...Commonly used schemes are based on nanoparticles attached either on the tip [205]–[207] or along a stripped part of a straight [208], [209] or bent [35], [210] optical fiber....
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TL;DR: An in-depth review of four devices for generating SPR is presented, and optical fiber is finally adopted for a substrate to generate SPR, and key challenges are identified to develop orientation of optical fiber biosensor based on SPR.
272 citations
References
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TL;DR: In this paper, a preliminary survey with the electron microscope of various preparations of colloidal gold, a study was made of the process of nucleation and growth in gold colloids, and it was shown that nucleating agents may be identified with reducing agents which form a mixed polymer with chlorauric ion before the reduction to the nucleus takes place.
Abstract: After a preliminary survey with the electron microscope of various preparations of colloidal gold, a study was made of the process of nucleation and growth in gold colloids. It was shown that nucleating agents may be identified with reducing agents which form a mixed polymer with chlorauric ion before the reduction to the nucleus takes place. It was also shown that the law of growth is exponential. The average size, the deviation from the average size and the character of the particle size distribution curve are determined by the amount of gold, the nucleation process and the law of growth.
6,593 citations
"Novel U-bent fiber optic probe for ..." refers methods in this paper
...Synthesis of gold nanoparticles Gold nanoparticles used in these experiments were syntheized by following a procedure described by Turkevich et al. (1951)....
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TL;DR: This work presents a meta-analysis of the literature on food quality and safety analysis and its applications in the context of veterinary drugs and drugs and drug-Induced Antibodies, which focuses on the role of canine coronavirus in the veterinary industry.
Abstract: 5.1. Detection Formats 475 5.2. Food Quality and Safety Analysis 477 5.2.1. Pathogens 477 5.2.2. Toxins 479 5.2.3. Veterinary Drugs 479 5.2.4. Vitamins 480 5.2.5. Hormones 480 5.2.6. Diagnostic Antibodies 480 5.2.7. Allergens 481 5.2.8. Proteins 481 5.2.9. Chemical Contaminants 481 5.3. Medical Diagnostics 481 5.3.1. Cancer Markers 481 5.3.2. Antibodies against Viral Pathogens 482 5.3.3. Drugs and Drug-Induced Antibodies 483 5.3.4. Hormones 483 5.3.5. Allergy Markers 483 5.3.6. Heart Attack Markers 484 5.3.7. Other Molecular Biomarkers 484 5.4. Environmental Monitoring 484 5.4.1. Pesticides 484 5.4.2. 2,4,6-Trinitrotoluene (TNT) 485 5.4.3. Aromatic Hydrocarbons 485 5.4.4. Heavy Metals 485 5.4.5. Phenols 485 5.4.6. Polychlorinated Biphenyls 487 5.4.7. Dioxins 487 5.5. Summary 488 6. Conclusions 489 7. Abbreviations 489 8. Acknowledgment 489 9. References 489
3,698 citations
"Novel U-bent fiber optic probe for ..." refers background in this paper
...Applications in different elds ranging from medical diagnostics to environmental monitorng have been explored (Homola, 2008)....
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TL;DR: In this article, the design and initial characterization of two-dimensional arrays of colloidal Au particles are reported, which are prepared by self-assembly of 12 nm diameter colloidal particles onto immobilized polymers having pendant functional groups with high affinity for Au (i.e., CN, SH, and NH 2 ).
Abstract: The design and initial characterization of two-dimensional arrays of colloidal Au particles are reported. These surfaces are prepared by self-assembly of 12 nm diameter colloidal Au particles onto immobilized polymers having pendant functional groups with high affinity for Au (i.e., CN, SH, and NH 2 ). The polymers are formed by condensation of functionalized alkoxysilanes onto cleaned quartz, glass, and SiO 2 surfaces. The assembly protocol is carried out completely in solution: cleaned substrates are immersed in methanolic solutions of organosilane, rinsed, and subsequently immersed in aqueous colloidal Au solutions. Two-dimensional arrays spontaneously form on the polymer surface. The resulting substrates have been characterized by UV-vis spectroscopy, transmission electron microscopy (TEM), and surface-enhanced Raman scattering (SERS). TEM data show that the particles are spatially separated but close enough to interact electromagnetically (small spacing compared to λ). The UV-vis data show that collective particle surface plasmon modes are present in the 650-750 nm region, suggesting that these assemblies are SERS-active. This is indeed the case, with enhancement factors of roughly. Au colloid monolayers possess a set of features that make them very attractive for both basic and applied uses, including uniform roughness, high stability, and biocompatibility
2,710 citations
"Novel U-bent fiber optic probe for ..." refers background or methods in this paper
...The plateau, observed at 650 nm in addition to the red shift, may have resulted from aggregation of GNP due to higher surface roughness of aminosilane layer on fiber and/or the size distribution of nanoparticles (Bar et al., 1996; Frederix et al., 2003; Grabar et al., 1995)....
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...These proprties of Au and Ag nanoparticles have been utilized in liquid phase s well as monolayers coated on glass/quartz substrates to develop olorimetric biosensors (Englebienne, 1998; Grabar et al., 1995; kamoto et al., 2000; Nath and Chilkoti, 2002; Lin et al., 2006; rederix et al., 2003)....
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01 Jan 2006
TL;DR: Applications of SPR Sensors for Detection of Biological and Chemical Analytes and Investigating Biomolecular Interactions and Binding Properties Using SPR Biosensors.
Abstract: Fundamentals of SPR Sensors.- Electromagnetic Theory of Surface Plasmons.- Surface Plasmon Resonance (SPR) Sensors.- Molecular Interactions in SPR Sensors.- Implementations of SPR Biosensors.- SPR Sensor Instrumentation.- The Art of Immobilization for SPR Sensors.- Applications of SPR Biosensors.- Investigating Biomolecular Interactions and Binding Properties Using SPR Biosensors.- SPR Biosensors for Detection of Biological and Chemical Analytes.- SPR Biosensors for Environmental Monitoring.- SPR Biosensors for Food Safety.- SPR Biosensors for Medical Diagnostics.
1,287 citations
"Novel U-bent fiber optic probe for ..." refers background in this paper
...In recent times, chemical and biochemical sensors based on surace plasmon resonance (SPR) and other label-free techniques have een developed by many researchers and subsequently commerialized (Homola, 2006; Cooper, 2006)....
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...Introduction In recent times, chemical and biochemical sensors based on surace plasmon resonance (SPR) and other label-free techniques have een developed by many researchers and subsequently commerialized (Homola, 2006; Cooper, 2006)....
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TL;DR: In this article, a review of the plasmon resonance (SPR) enhanced optical properties of noble metal nanoparticles is presented, with an emphasis on the recent advances in the utility of these plasmoric properties in molecular-specific imaging and sensing, photo-diagnostics, and selective photothermal therapy.
Abstract: Noble metal, especially gold (Au) and silver (Ag) nanoparticles exhibit unique and tunable optical properties on account of their surface plasmon resonance (SPR). In this review, we discuss the SPR-enhanced optical properties of noble metal nanoparticles, with an emphasis on the recent advances in the utility of these plasmonic properties in molecular-specific imaging and sensing, photo-diagnostics, and selective photothermal therapy. The strongly enhanced SPR scattering from Au nanoparticles makes them useful as bright optical tags for molecular-specific biological imaging and detection using simple dark-field optical microscopy. On the other hand, the SPR absorption of the nanoparticles has allowed their use in the selective laser photothermal therapy of cancer. We also discuss the sensitivity of the nanoparticle SPR frequency to the local medium dielectric constant, which has been successfully exploited for the optical sensing of chemical and biological analytes. Plasmon coupling between metal nanoparticle pairs is also discussed, which forms the basis for nanoparticle assembly-based biodiagnostics and the plasmon ruler for dynamic measurement of nanoscale distances in biological systems.
1,157 citations