Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease : Critical role for the astrocyte
Citations
4,075 citations
Cites background from "Nrf2-mediated neuroprotection in th..."
...On the other hand, activation of the transcription factor Nrf2 selectively in astrocytes protects mice from MPTP-induced Parkinsonism by activating anti-oxidative response pathways [40]....
[...]
3,891 citations
Cites background from "Nrf2-mediated neuroprotection in th..."
...…spectrum disorders, epilepsy, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and stroke (Matute et al., 2005; Tian et al., 2005; Nagai et al., 2007; Chen et al., 2009; Li et al., 2011; Lioy et al., 2011; Molofsky et al., 2012; Zamanian et al., 2012)....
[...]
...Accumulating evidence has demonstrated that glia are involved in a variety of neurological diseases, including schizophrenia, autism spectrum disorders, epilepsy, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and stroke (Matute et al., 2005; Tian et al., 2005; Nagai et al., 2007; Chen et al., 2009; Li et al., 2011; Lioy et al., 2011; Molofsky et al., 2012; Zamanian et al., 2012)....
[...]
2,987 citations
Cites background from "Nrf2-mediated neuroprotection in th..."
...Nrf2 KO mice were significantly more sensitive to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)induced PD-like lesions in mice, which are alleviated by overexpression of Nrf2 in astrocytes (170)....
[...]
1,336 citations
936 citations
Cites background from "Nrf2-mediated neuroprotection in th..."
...…and analyses of neurodegenerative models for motoneuron disorders and Parkinson’s disease or cerebral ischaemia disclosed that Nrf2-mediated neuroprotection may not only be directly mediated, but critically involves effects via astrocytes (Kraft et al., 2004; Shih et al., 2005b; Chen et al., 2009)....
[...]
...Ex vivo studies and analyses of neurodegenerative models for motoneuron disorders and Parkinson’s disease or cerebral ischaemia disclosed that Nrf2-mediated neuroprotection may not only be directly mediated, but critically involves effects via astrocytes (Kraft et al., 2004; Shih et al., 2005b; Chen et al., 2009)....
[...]
References
4,872 citations
2,526 citations
1,606 citations
"Nrf2-mediated neuroprotection in th..." refers methods in this paper
...-Galactosidase was excised from hGFAP- gal sequence by using NotI and replaced with mNrf2 (NotI–NotI fragment) from pEF-Nrf2 [received from Jawed Alam, Alton Ochsner Medical Foundation, New Orleans, LA (5)]....
[...]
1,373 citations
1,233 citations
"Nrf2-mediated neuroprotection in th..." refers background in this paper
...Dopaminergic neuron loss results in reduced striatal dopamine (DA) and the hallmark clinical features of PD (3)....
[...]