Nuclear factor interleukin 6 motifs mediate tissue-specific gene transcription in hypoxia.
Shi Fang Yan,Yu Shan Zou,Monica Mendelsohn,Yun Gao,Yoshifumi Naka,Shi Du Yan,David J. Pinsky,David M. Stern +7 more
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TLDR
Transgenic mice bearing either of the constructs showed prominent expression of the transgene in lung and cardiac vasculature and in the kidney but not in the liver, and tissue-specific pattern of gene expression suggests that local mechanisms have an important regulatory effect.About:
This article is published in Journal of Biological Chemistry.The article was published on 1997-02-14 and is currently open access. It has received 74 citations till now. The article focuses on the topics: Response element & Sp3 transcription factor.read more
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Regulation of mammalian o2 homeostasis by hypoxia-inducible factor 1
TL;DR: HIF-1 appears to function as a master regulator of O2 homeostasis that plays essential roles in cellular and systemic physiology, development, and pathophysiology.
Journal ArticleDOI
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
TL;DR: This review focuses on the mechanisms of HIF activation and their roles in physiological and pathophysiological responses to hypoxia, with an emphasis on the cardiorespiratory systems.
Journal ArticleDOI
Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors
Hugo H. Marti,Werner Risau +1 more
TL;DR: The results show that the response to hypoxia in vivo is differentially regulated at the level of specific cell types or layers in certain organs, which may influence their oxygenation after angiogenesis or modulate vascular permeability.
Journal ArticleDOI
The hypoxic tumour microenvironment and metastatic progression.
Patrick Subarsky,Richard P. Hill +1 more
TL;DR: The epigenetic control of gene expression by the hypoxic microenvironment and its potential contribution to metastatic progression are reviewed.
Journal Article
Candidate genes for the hypoxic tumor phenotype.
Albert C. Koong,Nicholas C. Denko,Karen M. Hudson,Cornelia Schindler,Lillian M. Swiersz,Cameron J. Koch,Sydney M. Evans,Hani Z. Ibrahim,Q.T. Le,David J. Terris,Amato J. Giaccia +10 more
TL;DR: Hypoxia-induced genes that included plasminogen activator inhibitor-1 (PAI-1), insulin-like growth factor-binding protein 3 (IGFBP-3), endothelin-2, low-density lipoprotein receptor-related protein (LRP), BCL2-interacting killer (BIK), migration-inhibitory factor (MIF), matrix metalloproteinase-13 (MMP-13), fibroblast growth factor
References
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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
TL;DR: A procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters, including tRNA and Ad 2 VA, is developed.
Journal ArticleDOI
Purification and Characterization of Hypoxia-inducible Factor 1
Guang L. Wang,Gregg L. Semenza +1 more
TL;DR: The biochemical purification of HIF-1 from Epo-producing Hep3B cells and non-Epo-producing HeLa S3 cells concludes that in both cobalt chloride-treated HeLa cells and hypoxic Hep3 B cells HIF -1 is composed of two different subunits: 120-kDa Hif-1α and 91-94-k da HIF,1β.
Journal ArticleDOI
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
TL;DR: In this article, the role of HIF-1 as a mediator of adaptive responses to hypoxia that underlie cellular and systemic oxygen homeostasis was investigated in Hep3B cells.
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A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.
Shizuo Akira,Hiroshi Isshiki,Takahisa Sugita,Osamu Tanabe,Shigemi Kinoshita,Yukihiro Nishio,Toshihiro Nakajima,Toshio Hirano,Tadamitsu Kishimoto +8 more
TL;DR: Interestingly, NF‐IL6 was shown to bind to the regulatory regions for various acute‐phase protein genes and several other cytokine genes such as TNF, IL‐8 and G‐CSF, implying that NF‐ IL6 has a role in regulation not only for the IL‐6 gene but also for several other genes involved in acute‐ phase reaction, inflammation and hemopoiesis.
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Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells Identification of a 5′ Enhancer
TL;DR: Using a DNA fragment containing human VEGF promoter sequence, a 28-bp element is identified that is necessary and sufficient to upregulate transcription in response to hypoxia and may be the binding site for certain constitutive binding proteins.
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Purification and Characterization of Hypoxia-inducible Factor 1
Guang L. Wang,Gregg L. Semenza +1 more