O colágeno em fáscia transversal de pacientes com hérnia inguinal direta submetidos à videolaparoscopia
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TLDR
The direct inguinal hernia patients have less collagen in transversalis fascia either absolutely or relatively to other constitutional elements, stablishing that there are less collagenIn the hernia's wall.Abstract:
OBJETIVO: Analisar quanto a espessura, elementos constitutivos e quantificacao do colageno total amostras de fascias transversais de pacientes entre 20 e 60 anos de idade, com hernia inguinal direta, coletadas no momento da correcao videolaparoscopica, comparando-as com amostras do mesmo tecido, retiradas de cadaveres. METODOS: Biopsias de 23 pacientes e de 22 cadaveres foram analisadas e comparadas. Utilizaram-se as tecnicas de coloracao de Hematoxilina-Eosina e Picrosirius. As imagens captadas foram analisadas por tecnica videomorfometrica assistida por computador. RESULTADOS: Constatou-se uma espessura de fascia transversal nos controles, em media, de 4.5 milimetros. A espessura da fascia transversal dos pacientes com hernia foi, em media, 58 % menor (p< 0.001). Nao se evidenciou algum processo de degeneracao das fibras de colageno atribuivel a senilidade. O principal elemento constitutivo da fascia, nos dois grupos, foi o tecido conjuntivo denso, representando cerca de 75 % nos controles e sendo um terco menor nos pacientes (p< 0.001). A area media percentual de colageno no campo amostral dos pacientes encontrada foi metade da area dos controles (p< 0.001), resultando em uma menor quantidade de colageno na parede posterior herniada. CONCLUSAO: Os pacientes com hernia inguinal direta apresentam menor quantidade de colageno tanto absoluta quanto relativamente aos demais elementos constitutivos da fascia transversal.read more
Citations
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Journal ArticleDOI
Etiology of inguinal hernia: ultrastructure of rectus sheath revisited.
TL;DR: The theory linking connective tissue alterations with the etiology of hernia, and stating that these alterations include connectives tissue at locations distant from the hernia site as well, is supported, as the rectus sheath itself does not form a hernial defect.
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Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats
TL;DR: Collagen was first seen on the 3rd day post-implantation, with a higher percentage of type I collagen at the last observational time point, and the prolonged healing inflammatory response and the persistence of chronic inflammation surrounding to the mesh did not affect the length of time required for fibroplasia.
Journal ArticleDOI
Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients.
Alberto Meyer,Eduardo Berger,Orlando Monteiro Jr.,Paulino Alberto Alonso,João Norberto Stavale,Marcelo Paulo Serafim Gonçalves +5 more
TL;DR: An increase in the quantity of collagen type III was found in patients with inguinal hernia and a greater quantity in those patients classified with Nyhus IIIa, and there is no significant difference in the quality of collagen in the fascia transversalis of patients compared to the controls.
Journal ArticleDOI
Qualitative and quantitative evaluation of total and types I and III collagens in patients with ventral hernias
TL;DR: The results of this study indicate a relationship between hernias of the anterior abdominal wall and smaller amounts of total and type I collagens.
References
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Comparison of Conventional Anterior Surgery and Laparoscopic Surgery for Inguinal-Hernia Repair
M. S. L. Liem,Y. van der Graaf,C. J. Van Steensel,R. U. Boelhouwer,G. J. Clevers,W. S. Meijer,Laurents P. S. Stassen,J. P. Vente,W. F. Weidema,A. J. P. Schrijvers,T. J. M. V. Van Vroonhoven +10 more
TL;DR: Patients with inguinal hernias who undergo laparoscopic repair recover more rapidly and have fewer recurrences than those who undergo open surgical repair.
Journal ArticleDOI
The use of the Picrosirius-polarization method for the study of the biopathology of collagen
Journal ArticleDOI
Increases in type III collagen gene expression and protein synthesis in patients with inguinal hernias.
David W. Friedman,Charles D. Boyd,Peggy Norton,Ralph S. Greco,Andrew H. Boyarsky,James W. Mackenzie,Susan B. Deak +6 more
TL;DR: This study represents the first attempt to define individuals with an abnormality in collagen production that may be specifically related to herniation, and suggests a constitutive and systemic increase in type III collagen synthesis may result in reduced collagen fibril assembly in the abdominal wall, eventually leading to the development of hernia.