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Journal ArticleDOI

O colágeno em fáscia transversal de pacientes com hérnia inguinal direta submetidos à videolaparoscopia

01 Jun 2003-Acta Cirurgica Brasileira (Acta Cirúrgica Brasileira/SOBRADPEC)-Vol. 18, Iss: 3, pp 0-0
TL;DR: The direct inguinal hernia patients have less collagen in transversalis fascia either absolutely or relatively to other constitutional elements, stablishing that there are less collagenIn the hernia's wall.
Abstract: OBJETIVO: Analisar quanto a espessura, elementos constitutivos e quantificacao do colageno total amostras de fascias transversais de pacientes entre 20 e 60 anos de idade, com hernia inguinal direta, coletadas no momento da correcao videolaparoscopica, comparando-as com amostras do mesmo tecido, retiradas de cadaveres. METODOS: Biopsias de 23 pacientes e de 22 cadaveres foram analisadas e comparadas. Utilizaram-se as tecnicas de coloracao de Hematoxilina-Eosina e Picrosirius. As imagens captadas foram analisadas por tecnica videomorfometrica assistida por computador. RESULTADOS: Constatou-se uma espessura de fascia transversal nos controles, em media, de 4.5 milimetros. A espessura da fascia transversal dos pacientes com hernia foi, em media, 58 % menor (p< 0.001). Nao se evidenciou algum processo de degeneracao das fibras de colageno atribuivel a senilidade. O principal elemento constitutivo da fascia, nos dois grupos, foi o tecido conjuntivo denso, representando cerca de 75 % nos controles e sendo um terco menor nos pacientes (p< 0.001). A area media percentual de colageno no campo amostral dos pacientes encontrada foi metade da area dos controles (p< 0.001), resultando em uma menor quantidade de colageno na parede posterior herniada. CONCLUSAO: Os pacientes com hernia inguinal direta apresentam menor quantidade de colageno tanto absoluta quanto relativamente aos demais elementos constitutivos da fascia transversal.

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06 Aug 2015
TL;DR: This study aimed to analyze the current literature on the subject "Collagen" in order to see how the extraction of this protein obtained from animals and their use can benefit human interests, especially with regard to aging.
Abstract: Collagen is abundant in animals, which may represent 25% to 30% of the body protein content. It performs many functions in living organisms, namely keeping the tissue cells together and strengthening them. It also participates in the process of healing and/or regeneration. Furthermore, it is related to the onset of diseases that are collectively known as collagenosis. Because of the importance of collagen to maintain homeostasis in the body, the interest of the pharmaceutical industry for this protein has been increasing. Generally studies have focused on the use of this protein for the retardation of aging, and one target intake collagen. This study aimed to analyze the current literature on the subject "Collagen" in order to see how the extraction of this protein obtained from animals and their use can benefit human interests, especially with regard to aging.
References
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Journal ArticleDOI
TL;DR: Patients with inguinal hernias who undergo laparoscopic repair recover more rapidly and have fewer recurrences than those who undergo open surgical repair.
Abstract: Background Inguinal hernias can be repaired by laparoscopic techniques, which have had better results than open surgery in several small studies. Methods We performed a randomized, multicenter trial in which 487 patients with inguinal hernias were treated by extraperitoneal laparoscopic repair and 507 patients were treated by conventional anterior repair. We recorded information about postoperative recovery and complications and examined the patients for recurrences one and six weeks, six months, and one and two years after surgery. Results Six patients in the open-surgery group but none in the laparoscopic-surgery group had wound abscesses (P = 0.03), and the patients in the laparoscopic-surgery group had a more rapid recovery (median time to the resumption of normal daily activity, 6 vs. 10 days; time to the return to work, 14 vs. 21 days; and time to the resumption of athletic activities, 24 vs. 36 days; P<0.001 for all comparisons). With a median follow-up of 607 days, 31 patients (6 percent) in the o...

559 citations

Journal ArticleDOI
TL;DR: This study represents the first attempt to define individuals with an abnormality in collagen production that may be specifically related to herniation, and suggests a constitutive and systemic increase in type III collagen synthesis may result in reduced collagen fibril assembly in the abdominal wall, eventually leading to the development of hernia.
Abstract: ObjectiveThe aim of this study was to determine if alterations in fibrillar collagen synthesis were associated with the development of inguinal hernias.Summary Background DataPrevious work has suggested that alterations in connective tissue accumulation may play a functional role in the development

189 citations

Journal ArticleDOI

188 citations