Journal ArticleDOI
O'nyong-nyong fever: An epidemic virus disease in East Africa VIII. Virus isolations from anopheles mosquitoes
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The findings strongly support the conclusions of previous studies in the field that Anopheles funestus was the vector of ONN virus, and that A. gambiae was also involved.Abstract:
Mosquitoes and bed-bugs were collected in 1959–1960 from places in Uganda and Kenya affected by the o'nyong-nyong epidemic. Tests indicated that 39 of 144 pools containing 5,784 Anopheles funestus , and 15 of 206 pools of 6,933 A. gambiae contained o'nyong-nyong (ONN) virus. No isolation was made from 60 pools containing 1,837 culicine mosquitoes of at least 15 species, or from 13 pools of more than 1,561 bed-bugs. Infected A. funestus and A. gambiae caught in the field maintained ONN virus for at least 20 and 13 days respectively, but limited transmission trials with monkeys and infant mice, through these mosquitoes, were unsuccessful. Transmission was, however, obtained with laboratory-infected mosquitoes of both species. The findings strongly support the conclusions of previous studies in the field that A. funestus was the vector of ONN virus, and that A. gambiae was also involved.read more
Citations
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Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more
TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.
Journal ArticleDOI
Re-emergence of Chikungunya and O'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships.
TL;DR: Phylogenetic trees corroborated historical evidence that CHIK virus originated in Africa and subsequently was introduced into Asia and revealed that ONN virus is indeed distinct from CHIK viruses, and these viruses probably diverged thousands of years ago.
Journal ArticleDOI
Anopheles gambiae complex and disease transmission in Africa
TL;DR: Anopheles gambiae complex mosquitoes are present throughout tropical Africa and its offshore islands and all members of the complex are proven or probable vectors of human malaria and filariasis, but with some wide contrasts in their levels of vectorial efficiency.
Journal ArticleDOI
RNA interference acts as a natural antiviral response to O'nyong-nyong virus (Alphavirus; Togaviridae) infection of Anopheles gambiae
Kimberly M. Keene,Brian D. Foy,Irma Sanchez-Vargas,Barry J. Beaty,Carol D. Blair,Ken E. Olson +5 more
TL;DR: Observations provide direct evidence that RNAi is an antagonist of ONNV replication in A. gambiae, and they suggest that the innate immune response conditions vector competence.
Journal ArticleDOI
Emerging arboviruses: Why today?
Ernest A. Gould,John H.-O. Pettersson,John H.-O. Pettersson,Stephen Higgs,Rémi N. Charrel,Xavier de Lamballerie +5 more
TL;DR: The recent global (re)emergence of arthropod-borne viruses (arboviruses), such as chikungunya and Zika virus, was widely reported in the media as though it was a new phenomenon, but this is not the case.
References
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Journal ArticleDOI
O'Nyong-Nyong Fever: an Epidemic Virus Disease in East Africa. III. Some Clinical and Epidemiológical Observations in the Northern Province of Uganda.
TL;DR: The typical syndrome consisted of joint pains, an irritating rash and lymphadenitis, and headache, fever, and post-orbital pain were other prominent signs and symptoms.
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O'nyong-nyong fever: An epidemic virus disease in East Africa 1. Introduction
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O'nyong-nyong fever: an epidemic virus disease in East Africa. II. Isolation and some properties of the virus.
M C Williams,J P Woodall +1 more
TL;DR: In this paper, the virus responsible for the epidemic of o'nyong-nyong (ONN) fever has been isolated from the serum of a febrile patient.
Journal ArticleDOI
O'nyong-nyong fever: an epidemic virus diesease in east africa. vii. virus isolations from man and serological studies up to july 1961.
Journal ArticleDOI
O'Nyong-Nyong fever: an epidemic virus disease in East Africa. IV. Vector studies at epidemic sites.
TL;DR: Between July and December 1959 four districts in Uganda and Kenya were visited while o'nyong-nyong fever was epidemic, and it is concluded that the main vector was A. funestus, the first record of an anopheline mosquito being recognized as the principal vector in an epidemic of virus disease in man.