Journal ArticleDOI
Obesity and colorectal cancer
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TLDR
In this paper, the authors found that obesity is associated with a 30-70% increased risk of colon cancer in men, whereas the association is less consistent in women, although the risk appears lower.Abstract:
Excess body weight, as defined by the body mass index (BMI), has been associated with several diseases and includes subjects who are overweight (BMI≥25–29.9 kg/m2) or obese (BMI≥30 kg/m2). Overweight and obesity constitute the fifth leading risk for overall mortality, accounting for at least 2.8 million adult deaths each year. In addition around 11% of colorectal cancer (CRC) cases have been attributed to overweight and obesity in Europe. Epidemiological data suggest that obesity is associated with a 30–70% increased risk of colon cancer in men, whereas the association is less consistent in women. Similar trends exist for colorectal adenoma, although the risk appears lower. Visceral fat, or abdominal obesity, seems to be of greater concern than subcutaneous fat obesity, and any 1 kg/m2 increase in BMI confers additional risk (HR 1.03). Obesity might be associated with worse cancer outcomes, such as recurrence of the primary cancer or mortality. Several factors, including reduced sensitivity to antiangiogenic-therapeutic regimens, might explain these differences. Except for wound infection, obesity has no significant impact on surgical procedures. The underlying mechanisms linking obesity to CRC are still a matter of debate, but metabolic syndrome, insulin resistance and modifications in levels of adipocytokines seem to be of great importance. Other biological factors such as the gut microbita or bile acids are emerging. Many questions still remain unanswered: should preventive strategies specifically target obese patients? Is the risk of cancer great enough to propose prophylactic bariatric surgery in certain patients with obesity?read more
Citations
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Journal ArticleDOI
Tales from the crypt: new insights into intestinal stem cells.
TL;DR: How the niche protects and instructs intestinal stem cells is investigated, which processes drive differentiation of mature cells and how imbalance in key signalling pathways can cause human disease are explored.
Journal ArticleDOI
Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer
Douglas K. Rex,C. Richard Boland,Jason A. Dominitz,Francis M. Giardiello,David A. Johnson,Tonya Kaltenbach,Theodore R. Levin,David Lieberman,Douglas J. Robertson +8 more
TL;DR: This document updates the colorectal cancer screening recommendations of the U.S. Multi-Society Task Force of Colorectals and suggests that the Septin9 serum assay (Epigenomics, Seattle, Wash) not be used for screening.
Journal ArticleDOI
Colorectal Cancer Screening: Recommendations for Physicians and Patients from the U.S. Multi-Society Task Force on Colorectal Cancer
Douglas K. Rex,C. Richard Boland,Jason A. Dominitz,Francis M. Giardiello,David A. Johnson,Tonya Kaltenbach,Theodore R. Levin,David Lieberman,Douglas J. Robertson +8 more
TL;DR: This document updates the colorectal cancer screening recommendations of the MSTF and suggests that the Septin9 serum assay (Epigenomics, Seattle, Wash) not be used for screening.
Journal ArticleDOI
Colorectal cancer screening: Recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer.
Douglas K. Rex,C. Richard Boland,Jason A. Dominitz,Francis M. Giardiello,David A. Johnson,Tonya Kaltenbach,Theodore R. Levin,David Lieberman,Douglas J. Robertson +8 more
TL;DR: This document updates the colorectal cancer (CRC) when persons up to date with screening, who have prior screening recommendations of the U.S. Multi-Society Task Force of ColoreCTal Cancer (MSTF), are required.
Journal ArticleDOI
Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women.
Po Hong Liu,Kana Wu,Kimmie Ng,Ann G. Zauber,Long H. Nguyen,Mingyang Song,Xiaosheng He,Charles S. Fuchs,Shuji Ogino,Walter C. Willett,Walter C. Willett,Andrew T. Chan,Edward Giovannucci,Yin Cao,Yin Cao +14 more
TL;DR: Obesity was associated with an increased risk of early-onset CRC among women and similar associations were observed among women without a family history of CRC and without lower endoscopy within the past 10 years.
References
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