Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus
Sheetal Hardikar,Sheetal Hardikar,Xiaoling Song,Rosa Ana Risques,Thomas J. Montine,Catherine Duggan,Patricia L. Blount,Patricia L. Blount,Brian J. Reid,Garnet L. Anderson,Garnet L. Anderson,Mario Kratz,Mario Kratz,Emily White,Emily White,Thomas L. Vaughan,Thomas L. Vaughan +16 more
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TLDR
Increasing age, male gender, smoking history, and sTNF-RI levels were associated with short LTL among persons with BE but no correlations were observed between LTL and other inflammatory markers or measures of obesity.Abstract:
Telomere shortening is associated with increasing age, male gender and lifestyle factors such as obesity and smoking. Inflammation has also been implicated in cellular senescence and may promote telomere shortening in chronic conditions such as obesity and diabetes. However, little is known about the relationship between markers of obesity and inflammation, and leukocyte telomere length (LTL). LTL was measured using quantitative polymerase chain reaction in peripheral leukocytes from 295 individuals diagnosed with Barrett’s esophagus (BE) between 1995 and 2009. Data on lifestyle variables including obesity and smoking were collected at in-person interviews. Biomarkers of obesity (leptin, adiponectin), diabetes (glucose, insulin), inflammation (C-reactive protein, Interleukin-6, surface tumor necrosis factor receptor (sTNFR) I & II) and oxidative stress (F2-isoprostanes) were measured in stored blood samples. We examined associations between these covariates and LTL in a cross-sectional analysis using linear and logistic regression models, adjusting for possible confounders. LTL was significantly associated with age (r = −0.30, p < 0.001), gender (r = 0.14 for females, p = 0.01) and inversely associated with cigarette pack-years (r = −0.11, p = 0.04). Odds of having short LTL were significantly higher for participants in the highest tertile for sTNF-RI (Odds ratio adjusted for age, gender, smoking, and obesity = 2.19; 95 % CI 1.00–4.85, p-trend = 0.02). LTL was not significantly associated with any other lifestyle factors, including smoking or obesity, or other inflammation-, obesity-/diabetes-related biomarkers measured. Increasing age, male gender, smoking history, and sTNF-RI levels were associated with short LTL among persons with BE but no correlations were observed between LTL and other inflammatory markers or measures of obesity. Larger longitudinal studies are necessary in order to further establish the potential relationships between obesity, inflammation markers and LTL.read more
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Association between telomere length and diabetes mellitus: A meta-analysis.
Jianfei Wang,Xu Dong,Li Cao,Yangyang Sun,Yu Qiu,Yi Zhang,Ruoqiong Cao,Mihai Covasa,Li Zhong,Li Zhong +9 more
TL;DR: The study demonstrated a close relationship between diabetes mellitus and telomere length, which was influenced by region, age, diabetes type, body mass index, BMI and sex.
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Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease
Beth J. Allison,Joepe J. Kaandorp,Andrew D. Kane,Emily J. Camm,Ciara Lusby,Christine M. Cross,Rhianon Nevin-Dolan,Avnesh S. Thakor,Jan B. Derks,Jane L. Tarry-Adkins,Susan E. Ozanne,Dino A. Giussani +11 more
TL;DR: Evidence is provided for divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease, and aging being decelerated by antioxidants even prior to birth.
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Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use.
Andrew M. Kaz,Andrew M. Kaz,Chao Jen Wong,Vinay Varadan,Joseph Willis,Amitabh Chak,William M. Grady,William M. Grady +7 more
TL;DR: Obesity and tobacco smoking may influence DNA methylation in the esophagus and raise the possibility that these risk factors affect the development of BE, dysplastic BE, and EAC through influencing the epigenetic status of specific loci that have a biologically plausible role in cancer formation.
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DNA damage in obesity: Initiator, promoter and predictor of cancer
M. Usman,Emanuela V. Volpi +1 more
TL;DR: The notion of genotoxicity, ensuing from systemic oxidative stress, as a key oncogenic factor in obesity is explored and advocated for early, pre-malignant assessment of genome integrity and stability to inform surveillance strategies and interventions.
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Shortened leukocyte telomere length in type 2 diabetes mellitus: genetic polymorphisms in mitochondrial uncoupling proteins and telomeric pathways.
TL;DR: This review discusses the contribution and balance of genetic regulation of UCPs and telomere pathways in the context of T2DM, and discusses genotypes that are well known to influence the shortening of LTL, in particular OBFC1 and telomerase genotypes such as TERC.
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