Object recognition test in mice
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Cites methods from "Object recognition test in mice"
...To gauge how combined GENUS impacts amyloid plaque abundance on a larger scale, we next performed whole brain SHIELD processing in 6-month-old 5XFAD mice followed by immunostaining for b-amyloid (D54D2) (STAR Methods)....
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...We presented 3- to 8-month-old male WT (C57BL6J) mice with 1 ms-long auditory tones coupled with 12.5 ms-long light pulses (auditory plus visual, or A+V, stimulation) at 40 Hz while recording neural activity in AC, CA1, or mPFC using 32-channel silicon probes as animals ran or rested on a spherical treadmill (STARMethods)....
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...We applied IMARIS to quantify the number of microglia within a 25 mm radius of an amyloid deposit from three-dimensional renderings of AC, VC, CA1, and mPFC images following combined GENUS versus no stimulation controls (Figures 6D and 6E, far right inset; Videos S1 and S2; STAR Methods)....
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...During the probe trial (STAR Methods), mice that received auditory GENUS, but not random frequency, spent a significantly longer time exploring the quadrant that previously contained the platform and had a higher number of crossings over the platform location, versus no stimulation controls (Figures 2I and 2J)....
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...(D) Immunohistochemistry and 3D reconstruction using IMARIS (STAR Methods) of anti-Iba1 (019- 19741, green) and anti-Ab (12F4, red) antibodies in AC, VC, CA1, and mPFC of 6-month-old 5XFAD mice after 7 days of 1 h/day (1 week) of no stimulation (n = 6 mice/group, top inset: example of using IMARIS to quantify the number of microglia surrounding a 25 mm radius around amyloid plaques)....
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314 citations
Cites methods or result from "Object recognition test in mice"
...The results of the novel object recognition test (Leger et al., 2013) (Figure 1B) indicate that memory was preserved in old mice fed a KD compared to those fed a control or LCD. Coordination, strength, and endurance were assessed with the hanging CMET 2387 2 Cell Metabolism 26, 1–8, September 5,…...
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...The results of the novel object recognition test (Leger et al., 2013) (Figure 1B) indicate that memory was preserved in old mice fed a KD compared to those fed a control or LCD....
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288 citations
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