Occurrence and fate of eleven classes of antibiotics in two typical wastewater treatment plants in South China.

doi:10.1016/J.SCITOTENV.2013.03.010

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Occurrence and fate of eleven classes of antibiotics in two typical wastewater treatment plants in South China.

Journal Article•DOI•

Occurrence and fate of eleven classes of antibiotics in two typical wastewater treatment plants in South China.

Li-Jun Zhou¹, Guang-Guo Ying¹, Shan Liu¹, Jian-Liang Zhao¹, Bin Yang¹, Zhi-Feng Chen¹, Hua-Jie Lai¹ - Show less +3 more•Institutions (1)

Chinese Academy of Sciences¹

01 May 2013-Science of The Total Environment (Elsevier)-Vol. 452, pp 365-376

TL;DR: Twenty-one antibiotics were found in the sewage sludge from the two WWTPs at the concentrations up to 5800ng/g, with tetracycline, oxytetracy Cline, norfloxacin and ofloxacIn being the predominant antibiotics.

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About: This article is published in Science of The Total Environment.The article was published on 2013-05-01. It has received 377 citations till now. The article focuses on the topics: Sludge & Activated sludge.

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Journal Article•DOI•

Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance.

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Qianqian Zhang¹, Guang-Guo Ying¹, Chang-Gui Pan¹, You-Sheng Liu¹, Jian-Liang Zhao¹ - Show less +1 more•Institutions (1)

Chinese Academy of Sciences¹

21 May 2015-Environmental Science & Technology

TL;DR: This is the first comprehensive study which demonstrates an alarming usage and emission of various antibiotics in China and the bacterial resistance rates in the hospitals and aquatic environments were found to be related to the PECs and antibiotic usages, especially for those antibiotics used in the most recent period.

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Abstract: Antibiotics are widely used in humans and animals, but there is a big concern about their negative impacts on ecosystem and human health after use. So far there is a lack of information on emission inventory and environmental fate of antibiotics in China. We studied national consumption, emissions, and multimedia fate of 36 frequently detected antibiotics in China by market survey, data analysis, and level III fugacity modeling tools. Based on our survey, the total usage for the 36 chemicals was 92700 tons in 2013, an estimated 54000 tons of the antibiotics was excreted by human and animals, and eventually 53800 tons of them entered into the receiving environment following various wastewater treatments. The fugacity model successfully predicted environmental concentrations (PECs) in all 58 river basins of China, which are comparable to the reported measured environmental concentrations (MECs) available in some basins. The bacterial resistance rates in the hospitals and aquatic environments were found to b...

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2,651 citations

Journal Article•DOI•

Occurrence and fate of emerging contaminants in municipal wastewater treatment plants from different geographical regions-a review.

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Ngoc Han Tran¹, Martin Reinhard², Karina Yew-Hoong Gin¹•Institutions (2)

National University of Singapore¹, Stanford University²

15 Apr 2018-Water Research

TL;DR: Many antibiotics were detected in the influents and effluents of WWTPs at concentrations close to or exceeding the predicted no-effect concentrations (PNECs) for resistance selection.

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993 citations

Journal Article•DOI•

Review of antibiotic resistance in China and its environment

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Min Qiao¹, Guang-Guo Ying¹, Andrew C. Singer, Yong-Guan Zhu¹•Institutions (1)

Chinese Academy of Sciences¹

01 Jan 2018-Environment International

TL;DR: It is important to understand the current state of antibiotic use in China and its relationship to ARG prevalence and diversity in the environment, and also future needs in mitigating the spread of antibiotic resistance in the environments, particularly under the 'planetary health' perspective.

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932 citations

Journal Article•DOI•

Antibiotic pollution in the environment: a review.

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Ritu Gothwal, Thhatikkonda Shashidhar

01 Apr 2015-Clean-soil Air Water

TL;DR: In this paper, the authors collected information from several investigations on the sources and occurrences of antibiotics in natural and artificial environmental systems, including water resources, effluent from industries, sludge, manure, soil, plants, and organisms across the globe.

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Abstract: Antibiotics have been extensively and effectively used in human and veterinary medicines. Their benefits have been recognized in agriculture, aquaculture, bee-keeping, and livestock as growth promoters. This paper collects information from several investigations on the sources and occurrences of antibiotics in natural and artificial environmental systems. Several antibiotics were reported for their occurrences in water resources, effluent from industries, sludge, manure, soil, plants, and organisms across the globe. Sorption, photo-degradation, biodegradation, and oxidation were recognized as the main elimination pathways for these compounds and have been discussed in detail. The adverse effects of the pollutants were also highlighted and necessary suggestions were made for effective monitoring and mitigating pollution, which may provide the scope for future research.

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481 citations

Journal Article•DOI•

Insights into the Fate and Removal of Antibiotics in Engineered Biological Treatment Systems: A Critical Review

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Akashdeep Singh Oberoi, Yanyan Jia¹, Huiqun Zhang, Samir Kumar Khanal², Hui Lu - Show less +1 more•Institutions (2)

Hong Kong University of Science and Technology¹, University of Hawaii at Manoa²

03 Jun 2019-Environmental Science & Technology

TL;DR: This review systematically summarizes the behavior and removal of different antibiotics in various biological treatment systems with discussion on their removal efficiency, removal mechanisms, critical bioreactor operating conditions affecting antibiotics removal, and recent innovative advancements.

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Abstract: Antibiotics, the most frequently prescribed drugs of modern medicine, are extensively used for both human and veterinary applications. Antibiotics from different wastewater sources (e.g., municipal, hospitals, animal production, and pharmaceutical industries) ultimately are discharged into wastewater treatment plants. Sorption and biodegradation are the two major removal pathways of antibiotics during biological wastewater treatment processes. This review provides the fundamental insights into sorption mechanisms and biodegradation pathways of different classes of antibiotics with diverse physical-chemical attributes. Important factors affecting sorption and biodegradation behavior of antibiotics are also highlighted. Furthermore, this review also sheds light on the critical role of extracellular polymeric substances on antibiotics adsorption and their removal in engineered biological wastewater treatment systems. Despite major advancements, engineered biological wastewater treatment systems are only moderately effective (48-77%) in the removal of antibiotics. In this review, we systematically summarize the behavior and removal of different antibiotics in various biological treatment systems with discussion on their removal efficiency, removal mechanisms, critical bioreactor operating conditions affecting antibiotics removal, and recent innovative advancements. Besides, relevant background information including antibiotics classification, physical-chemical properties, and their occurrence in the environment from different sources is also briefly covered. This review aims to advance our understanding of the fate of various classes of antibiotics in engineered biological wastewater treatment systems and outlines future research directions.

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454 citations

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References

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Journal Article•DOI•

Antibiotics in the aquatic environment - A review - Part II

[...]

Klaus Kümmerer¹•Institutions (1)

University Medical Center Freiburg¹

01 Apr 2009-Chemosphere

TL;DR: This review brings up important questions that are still open, and addresses some significant issues which must be tackled in the future for a better understanding of the behavior of antibiotics in the environment, as well as the risks associated with their occurrence.

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3,620 citations

"Occurrence and fate of eleven class..." refers background in this paper

...Antibiotics are extensively used in the treatment of humans and animals for various diseases and/or growth promotion (Kummerer, 2009; Sarmah et al., 2006)....
[...]

Journal Article•DOI•

A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment

[...]

Ajit K. Sarmah¹, Michael T. Meyer², Alistair B.A. Boxall³•Institutions (3)

Landcare Research¹, United States Geological Survey², University of York³

01 Oct 2006-Chemosphere

TL;DR: This paper has attempted to summarize the latest information available in the literature on the use, sales, exposure pathways, environmental occurrence, fate and effects of veterinary antibiotics in animal agriculture.

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2,856 citations

"Occurrence and fate of eleven class..." refers background in this paper

...Antibiotics are extensively used in the treatment of humans and animals for various diseases and/or growth promotion (Kummerer, 2009; Sarmah et al., 2006)....
[...]

Journal Article•DOI•

Occurrence of antibiotics in the aquatic environment.

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Roman Hirsch, Thomas A. Ternes, Klaus Haberer, Karl-Ludwig Kratz¹•Institutions (1)

University of Mainz¹

12 Jan 1999-Science of The Total Environment

TL;DR: From the large number of ground water samples that were taken from agricultural areas in Germany, no contamination by antibiotics was detected except for two sites, which indicates that intake from veterinary applications to the aquatic environment is of minor importance.

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2,070 citations

"Occurrence and fate of eleven class..." refers background in this paper

...Various antibiotics have been frequently detected in groundwater (Barnes et al., 2008; Batt et al., 2006a), drinking water (Focazio et al., 2008), surface water (Hirsch et al., 1999; Yang et al., 2011), sediment (Zhou et al., 2011) and agricultual lands (Hu et al., 2010; Karci and Balcioglu, 2009)....
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..., 2008), surface water (Hirsch et al., 1999; Yang et al., 2011), sediment (Zhou et al....
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Journal Article•DOI•

Veterinary antibiotics in the aquatic and terrestrial environment

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Nicole Kemper¹•Institutions (1)

University of Kiel¹

01 Jan 2008-Ecological Indicators

TL;DR: A review of the available data on the present use of veterinary antibiotics in agriculture, on the occurrence of antibiotic compounds and resistant bacteria in soil and water and demonstrates the need for further studies as mentioned in this paper.

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1,218 citations

"Occurrence and fate of eleven class..." refers background in this paper

...Livestock wastes containing antibiotic residues are directly or indirectly discharged into surface water or applied onto agricultural lands with little treatment (Kemper, 2008)....
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...Chlortetracycline is less commonly used in humans, but it is widely used in animals to prevent and treat disease (Kemper, 2008)....
[...]
..., 2007), probably due to its main application in animals (Kemper, 2008)....
[...]
...…and oxytetracycline were found at much higher concentrations than chlortetracycline and doxycycline in the influents and effluents of both plant A and plant B. Chlortetracycline is less commonly used in humans, but it is widely used in animals to prevent and treat disease (Kemper, 2008)....
[...]
...…occurrence of lincomycin has been less reported in domestic wastewater (Watkinson et al., 2007), probably due to its main application in animals (Kemper, 2008). β-Lactams, including penicillins and cephalosporins, have not been detected frequently in wastewater because of easy hydrolytic…...
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Journal Article•DOI•

Removal of antibiotics in conventional and advanced wastewater treatment: implications for environmental discharge and wastewater recycling.

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A. J. Watkinson¹, E.J. Murby², S. D. Costanzo¹•Institutions (2)

University of Queensland¹, National Measurement Institute²

01 Oct 2007-Water Research

TL;DR: Certain traditional parameters, including nitrate concentration, conductivity and turbidity of the effluent were assessed as predictors of total antibiotic concentration, however only conductivity demonstrated any correlation with total antibiotics concentration.

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991 citations

"Occurrence and fate of eleven class..." refers background in this paper

...Antibiotics from human sources can enter into the environment through discharge of treated effluents and sludge from domestic wastewater treatment plants (WWTPs) due to incomplete removal, and untreated wastewaters (Batt et al., 2006b; Watkinson et al., 2007; Xu et al., 2007)....
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...In fact, the occurrence of lincomycin has been less reported in domestic wastewater (Watkinson et al., 2007), probably due to its main application in animals (Kemper, 2008)....
[...]
...In fact, the occurrence of lincomycin has been less reported in domestic wastewater (Watkinson et al., 2007), probably due to its main application in animals (Kemper, 2008). β-Lactams, including penicillins and cephalosporins, have not been detected frequently in wastewater because of easy…...
[...]
...Up to now, most studies on antibiotics in WWTPs focused on the concentration levels of certain antibiotics such as sulfamethoxazole, tetracycline and ciprofloxacin in influent, effluent and sludge (Batt et al., 2006b; Gao et al., 2012; Watkinson et al., 2007; Xu et al., 2007)....
[...]
...…concentrations have also been observed in the wastewaters of other WWTPs in China (Gao et al., 2012; Jia et al., 2012; Leung et al., 2012; Li and Zhang, 2010; Xu et al., 2007) and other countries (Golet et al., 2003; Karthikeyan and Meyer, 2006; Lindberg et al., 2005; Watkinson et al., 2007)....
[...]