Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling
Felipe Ortega,Felipe Ortega,Susan Gascon,Giacomo Masserdotti,Aditi Deshpande,Christiane Simon,Judith Fischer,Leda Dimou,D. Chichung Lie,Timm Schroeder,Benedikt Berninger +10 more
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TLDR
In vivo activation or inhibition of canonical Wnt signalling respectively increased or decreased the number of Olig2 and PDGFR- α positive cells, suggesting that this pathway contributes to the fine tuning of oligodendrogliogenesis in the adult SEZ.Abstract:
Adult mouse subependymal neural stem cells (aNSCs) give rise to neuronal and oligodendroglial progeny. Berninger and colleagues use continuous live imaging and single-cell tracking to demonstrate that single aNSCs isolated from the mouse brain generate exclusively either oligodendrocytes or neurons. They also show that Wnt activation stimulates oligodendrogenic progenitor proliferation without affecting neurogenic clones.read more
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Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury.
Enric Llorens-Bobadilla,Sheng Zhao,Avni Baser,Gonzalo Saiz-Castro,Klara Zwadlo,Ana Martin-Villalba +5 more
TL;DR: This study unveils general principles underlying NSC activation and lineage priming and opens potential avenues for regenerative medicine in the brain.
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Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
TL;DR: Recent progress is reviewed and questions related to adult mammalian neural stem cells that also apply to other somatic stem cells are focused on.
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Prospective Identification and Purification of Quiescent Adult Neural Stem Cells from Their In Vivo Niche
Paolo Codega,Violeta Silva-Vargas,Alex Paul,Angel R. Maldonado-Soto,Annina M. DeLeo,Erika Pastrana,Fiona Doetsch +6 more
TL;DR: In this paper, GFAP(+)CD133(+) (quiescent neural stem cells [qNSCs]) and GFAP (+)CD 133(+)EGFR(+) [aNSC] were isolated from the adult ventricular-subventricular zone.
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The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis.
TL;DR: The rapidly expanding cellular and molecular knowledge of V-SVZ NSC biology provides key insights into postnatal neural development, the origin of brain tumors, and may inform the development regenerative therapies from cultured and endogenous human neural precursors.
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Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone
TL;DR: It is suggested that activated microglia accumulate in the early postnatal SVZ and that they enhance neurogenesis and oligodendrogenesis via released cytokines.
References
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Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain
Fiona Doetsch,Isabelle Caillé,Daniel A. Lim,José Manuel García-Verdugo,Arturo Alvarez-Buylla +4 more
TL;DR: It is shown that SVZ astrocytes act as neural stem cells in both the normal and regenerating brain and give rise to cells that grow into multipotent neurospheres in vitro.
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TL;DR: Grafted and endogenous SVZ cells in the lateral ventricle of adult mice migrate long distances and differentiate into neurons in the olfactory bulb.
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TL;DR: The timing in development and location of NSCs, a property tightly linked to their neuroepithelial origin, appear to be the key determinants of the types of neurons generated.
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Wnt signalling regulates adult hippocampal neurogenesis
Dieter Chichung Lie,Sophia A. Colamarino,Hongjun Song,Hongjun Song,Laurent Désiré,Helena Mira,Antonella Consiglio,Edward S. Lein,Sebastian Jessberger,Heather Lansford,Alejandro R. Dearie,Fred H. Gage +11 more
TL;DR: It is shown that adult hippocampal stem/progenitor cells (AHPs) express receptors and signalling components for Wnt proteins, which are key regulators of neural stem cell behaviour in embryonic development, and that the Wnt/β-catenin pathway is active and that Wnt3 is expressed in the hippocampal neurogenic niche.