On a roll for new TRF targets
Jaime H. Reina,Nouria Hernandez +1 more
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TLDR
In this issue of Genes & Development, Isogai et al. (2007a) report that the TATA-less histone H1 promoter is regulated by TRF2, which provides a possible mechanism for earlier observations linking TRF3 with chromatin structure and helps to establish Drosophila TRF 2 as a broadly used core-promoter factor.Abstract:
In the early 1990s, one of us wrote in these pages a review entitled “TBP, a universal transcription factor?” (Hernandez 1993). At the time, it had become clear that the TATA-box-binding protein TBP was not a transcription factor exclusively involved in transcription from RNA polymerase II (pol II) promoters as had been thought before, but rather a factor involved in transcription by all three main types of eukaryotic nuclear RNA polymerases. In retrospect, however, the question mark at the end of the title was a wise touch! Indeed, shortly thereafter, the first TBP-related factor, TRF1, was described (Crowley et al. 1993). Since then, two more TRFs have been discovered (for review, see Berk 2000; Davidson 2003; Hochheimer and Tjian 2003), and it was found that some genes dispense with TBP and TRFs altogether (Wieczorek et al. 1998). This “expansion” of TBP into a TBP family of proteins begs the question of which promoters are targeted by which TBP family member. In this issue of Genes & Development, Isogai et al. (2007a) report that the TATA-less histone H1 promoter is regulated by TRF2. This provides a possible mechanism for earlier observations linking TRF2 with chromatin structure (Martianov et al. 2002; Kopytova et al. 2006). Furthermore, the identification by Isogai et al. (2007a) of a large number of TRF2-bound sites in the Drosophila genome helps to establish Drosophila TRF2 as a broadly used core-promoter factor. Among the three classes of TBP-related factors described so far, TRF2—also called TBP-like protein (TLP) or TBP-like factor (TLF)—is the only one to be widely present in metazoans (Ohbayashi et al. 1999; Kaltenbach et al. 2000; Veenstra et al. 2000). TRF1 has been found only in Drosophila and Anopheles (Crowley et al. 1993; Isogai et al. 2007b), and TRF3 is restricted to vertebrates (Persengiev et al. 2003). All three proteins contain a core domain related to the TBP C-terminal core domain, and some also contain variable Nand C-terminal domains.read more
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Journal ArticleDOI
TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte.
Emese Gazdag,Angèle Santenard,Céline Ziegler-Birling,Gioia Altobelli,Olivier Poch,Laszlo Tora,Maria-Elena Torres-Padilla +6 more
TL;DR: It is demonstrated that T BP2 is essential for the differentiation of female germ cells, and mutually exclusive functions of these key core promoter-binding factors, TBP and TBP2, in the mouse are shown.
Journal ArticleDOI
Promoting developmental transcription.
Uwe Ohler,David A. Wassarman +1 more
TL;DR: Recent studies that have uncovered significant regulatory functions in developmental transcription for the TFIID basal transcription factors and for the DNA core promoter elements that are located close to transcription start sites are reviewed.
Journal ArticleDOI
TRF2, but not TBP, mediates the transcription of ribosomal protein genes
Yuan-Liang Wang,Sascha H. Duttke,Kai Chen,Jeff Johnston,George A. Kassavetis,Julia Zeitlinger,James T. Kadonaga +6 more
TL;DR: It is shown that TBP (TATA box-binding protein)-related factor TRF2, but not TBP, is required for transcription of the TCT-dependent RP genes, and a specialized TRF 2-based RNA polymerase II system functions in the synthesis of RPs and complements the RNA polymerases I and III systems.
Journal ArticleDOI
Distinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID.
TL;DR: Both the SAGA and TFIID complexes are highly conserved from yeast to human, and play crucial roles in gene activation among eukaryotes, and are discussed here.
Journal ArticleDOI
Drosophila TRF2 is a preferential core promoter regulator.
Adi Kedmi,Yonathan Zehavi,Yair Glick,Yaron Orenstein,Diana Ideses,Chaim Wachtel,Tirza Doniger,Hiba Waldman Ben-Asher,Nemone Muster,James Thompson,Scott Anderson,Dorit Avrahami,John R. Yates,Ron Shamir,Doron Gerber,Tamar Juven-Gershon +15 more
TL;DR: This work identified the Drosophila TBP (TATA-box-binding protein)-related factor 2 (TRF2) as an enriched factor in the fractions that support DPE-dependent transcription and shows the importance of the DPE in transcriptional regulation of TRF2 target genes.
References
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TL;DR: The author’s views are based on personal experience, research, and interviews conducted at the 2016 USGS workshop on “Biology of infectious disease: Foundations of Natural Selection and Response to infectious disease .”