On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves
Xiaoyun Ding,Sz-Chin Steven Lin,Brian Kiraly,Hongjun Yue,Sixing Li,I-Kao Chiang,Jinjie Shi,Stephen J. Benkovic,Tony Jun Huang +8 more
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TLDR
Standing surface acoustic wave based “acoustic tweezers” are demonstrated that can trap and manipulate single microparticles, cells, and entire organisms in a single-layer microfluidic chip and will become a powerful tool for many disciplines of science and engineering.Abstract:
Techniques that can dexterously manipulate single particles, cells, and organisms are invaluable for many applications in biology, chemistry, engineering, and physics. Here, we demonstrate standing surface acoustic wave based “acoustic tweezers” that can trap and manipulate single microparticles, cells, and entire organisms (i.e., Caenorhabditis elegans) in a single-layer microfluidic chip. Our acoustic tweezers utilize the wide resonance band of chirped interdigital transducers to achieve real-time control of a standing surface acoustic wave field, which enables flexible manipulation of most known microparticles. The power density required by our acoustic device is significantly lower than its optical counterparts (10,000,000 times less than optical tweezers and 100 times less than optoelectronic tweezers), which renders the technique more biocompatible and amenable to miniaturization. Cell-viability tests were conducted to verify the tweezers’ compatibility with biological objects. With its advantages in biocompatibility, miniaturization, and versatility, the acoustic tweezers presented here will become a powerful tool for many disciplines of science and engineering.read more
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Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation
TL;DR: This review examines the breadth of microfluidic cell sorting technologies, while focusing on those that offer the greatest potential for translation into clinical and industrial practice and that offer multiple, useful functions.
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Xiaoyun Ding,Peng Li,Sz-Chin Steven Lin,Zackary S. Stratton,Nitesh Nama,Feng Guo,Daniel J. Slotcavage,Xiaole Mao,Jinjie Shi,Francesco Costanzo,Tony Jun Huang +10 more
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Asier Marzo,Sue Ann Seah,Bruce W. Drinkwater,Deepak Ranjan Sahoo,Benjamin Long,Sriram Subramanian +5 more
TL;DR: The phases used to drive an ultrasonic phased array are optimized and it is shown that acoustic levitation can be employed to translate, rotate and manipulate particles using even a single-sided emitter.
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Acoustic tweezers for the life sciences
Adem Ozcelik,Joseph Rufo,Feng Guo,Yuyang Gu,Peng Li,James P. Lata,Tony Jun Huang,Tony Jun Huang +7 more
TL;DR: This review discusses and contrasts different acoustic-tweezer technologies and their applications in biology and summarizes recent breakthroughs.
References
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Journal ArticleDOI
Observation of a single-beam gradient force optical trap for dielectric particles
TL;DR: Optical trapping of dielectric particles by a single-beam gradient force trap was demonstrated for the first reported time, confirming the concept of negative light pressure due to the gradient force.
Journal ArticleDOI
A revolution in optical manipulation
TL;DR: This research presents the next generation of single-beam optical traps, which promise to take optical tweezers out of the laboratory and into the mainstream of manufacturing and diagnostics and even become consumer products.
Journal ArticleDOI
Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
Keir C. Neuman,Attila Nagy +1 more
TL;DR: These techniques are described and illustrated with examples highlighting current capabilities and limitations of single-molecule force spectroscopy.
Journal ArticleDOI
Massively parallel manipulation of single cells and microparticles using optical images.
TL;DR: An optical image-driven dielectrophoresis technique that permits high-resolution patterning of electric fields on a photoconductive surface for manipulating single particles and requires 100,000 times less optical intensity than optical tweezers is presented.
Journal ArticleDOI
Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics
James Friend,Leslie Y. Yeo +1 more
TL;DR: In this article, the use of acoustic fields, principally ultrasonics, for application in microfluidics is reviewed, and the abundance of interesting phenomena arising from nonlinear interactions in ultrasound that easily appear at these small scales is considered, especially in surface acoustic wave devices that are simple to fabricate with planar lithography techniques.