On modeling of airflow in human lungs: constitutive relations to describe deformation of porous medium

TLDR: In this paper, the meso-level model of the human respiratory system is presented, where air movement in the deformable porous medium of lungs is described by ratios of the mechanics of deformable solid body and filtration theory.

Abstract: Within the framework of a multilevel mathematical model to describe the evolution of functional disorders of the human organism under the influence of environment factors, a mathematical model of the "meso-level" of the human respiratory system is developed. The article is deals with the development of the meso-level model - the formulation of a constitutive model to describe the airflow in a porous lung medium. Human lungs filled with small airways and alveoli, with air contained in them, are modeled by an elastically deformable saturated porous medium enclosed in an internal chamber with varying volume (movable walls). Conceptual and mathematical statements are presented. Air movement in the deformable porous medium of lungs is described by ratios of the mechanics of deformable solid body and filtration theory. As an element of this sub-model an analytical solution is obtained for an auxiliary geometrically linear problem of the all-round compression of an elastic thin-walled hollow sphere filled with air to determine the rate of mean stress of the two-phase medium of the lungs, taking into account the interaction between the lung tissue and the air contained in the lungs. To confirm the hypothesis on the acceptability of a linear solution of an auxiliary problem for large deformations, a similar problem was numerically solved in a geometrically nonlinear formulation. The results show that the obtained analytical solution is in satisfactory agreement with the solution of a similar problem in a nonlinear formulation both for calm and deep breathing, which indicates the possibility of using the former in the construction of the considered sub-model.