Journal ArticleDOI
On the history of oxidative stress: Concept and some aspects of current development
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TLDR
Sies et al. as discussed by the authors defined a global concept of Oxidative Stress as an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage.About:
This article is published in Current Opinion in Toxicology.The article was published on 2018-02-01. It has received 169 citations till now. The article focuses on the topics: Oxidative stress.read more
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Book ChapterDOI
Oxidative Stress: Eustress and Distress in Redox Homeostasis
TL;DR: The global concept of oxidative stress is defined as an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage as discussed by the authors.
Journal ArticleDOI
Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status.
Aurelia Magdalena Pisoschi,Aneta Pop,Florin Iordache,Loredana Stanca,Gabriel Predoi,Andreea Iren Serban +5 more
TL;DR: The present review paper focuses on the chemistry of oxidative stress mitigation by antioxidants, and the specific mechanism of a series of endogenous and exogenous antioxidants in particular aspects of oxidative Stress, is detailed.
Journal ArticleDOI
Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update
TL;DR: This new direction in improving antioxidant defences for poultry in stress conditions is related to an opportunity to activate a range of vitagenes via Nrf2-related mechanisms to maximise internal AO protection and redox balance maintenance.
Journal ArticleDOI
The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview.
Jelena Dumanovic,Jelena Dumanovic,Eugenie Nepovimova,Maja Natić,Kamil Kuca,Vesna Jaćević,Vesna Jaćević +6 more
TL;DR: In plants, there is a complex and multilevel network of the antioxidative system (AOS) operating to counteract harmful reactive species (RS), the foremost important of which are reactive oxygen species (ROS), and maintain homeostasis within the cell as discussed by the authors.
Journal ArticleDOI
Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts
TL;DR: The importance of reactive oxygen species (ROS) in regulating cell functioning and communication among themselves and the relevance of ROS in therapy concepts is addressed here.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Oxidants, oxidative stress and the biology of ageing.
Toren Finkel,Nikki J. Holbrook +1 more
TL;DR: Evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span is reviewed.
Journal ArticleDOI
Hydroperoxide metabolism in mammalian organs.
Journal ArticleDOI
Oxidative stress: oxidants and antioxidants
TL;DR: These low molecular mass antioxidant molecules add significantly to the defense provided by the enzymes superoxide dismutase, catalase and glutathione peroxidases, which are termed ‘oxidative stress’.