Journal ArticleDOI
On the mechanism of apoptosis-inducing activity of human calprotectin: zinc sequestration, induction of a signaling pathway, or something else?
Hakimeh Zali,Sayed-Amir Marashi,Mostafa Rezaei-Tavirani,Parviz Toossi,Mohammad Rahmati-Roodsari,Mohammad Ali Shokrgozar +5 more
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TLDR
It is suggested that calprotectin might become internalized non-specifically, maybe in a process like pinocytosis, and it is demonstrated that the internal target hypothesis successfully predicts cell survival behavior of cultured cells as a function of cal Protectin concentration.About:
This article is published in Medical Hypotheses.The article was published on 2007-01-01. It has received 16 citations till now. The article focuses on the topics: Calprotectin.read more
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Between-assay variability of faecal calprotectin enzyme-linked immunosorbent assay kits
TL;DR: Evaluated and compared the performance of the Immunodiagnostik, Bühlmann and Eurospital f-Cp ELISA assays as well as the Roche, immunosorbent and ScheBo Biotech commercial faecal extraction devices and briefly reports results from a pilot EQA scheme.
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New Insights into the Role of Zinc Acquisition and Zinc Tolerance in Group A Streptococcal Infection
TL;DR: It is demonstrated that nutritional immunity is deployed extracellularly, while zinc toxicity is utilized upon phagocytosis of GAS by neutrophils, and that lysosomes and azurophilic granules in neutrophil contain zinc stores for use against intracellular pathogens.
Journal ArticleDOI
Design and synthesis of a caged Zn2+ probe, 8-benzenesulfonyloxy-5-N,N-dimethylaminosulfonylquinolin-2-ylmethyl-pendant 1,4,7,10-tetraazacyclododecane, and its hydrolytic uncaging upon complexation with Zn2+.
Shin Aoki,Kazusa Sakurama,Ryosuke Ohshima,Nanako Matsuo,Yasuyuki Yamada,Ryoko Takasawa,Sei-ichi Tanuma,Kei Takeda,Eiichi Kimura +8 more
TL;DR: Improvement of cell membrane permeation in comparison with L(4) is also described, results from the formation of Zn(H-1L(4)) by the hydrolysis of the sulfonyl ester at the 8-position of the quinoline unit promoted by the Zn (2+)-bound HO(-).
Journal Article
Evaluation of Depression in Patients With Cancer In South of Iran (Zahedan)
TL;DR: The prevalence of depression and its severity in cancer patients in South east of Iran was lower than other studies and it seems that this situation may be related to high religious beliefs in this region, high prevalence of illiteracy and lack of knowledge about their underlying disease.
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A Practical Guide for Faecal Calprotectin Measurement: Myths and Realities
TL;DR: This work provides for the first time practical advices to minimize dosage variability, but further dedicated studies are needed to compare commercially available tests and identify the best tools for the most precise and accurate FC measurement.
References
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Comparison of the Sensitivity of Normal Hematopoietic and Transplanted Lymphoma Colony-Forming Cells to Chemotherapeutic Agents Administered In Vivo
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Proliferation-dependent Cytotoxicity of Anticancer Agents: A Review
F Valeriote,L. M. van Putten +1 more
TL;DR: In this review, the cellular aspects of this differential sensitivity of proliferating cells are discussed with the hemopoietic stem cell population and tissue culture cells as the focus for the analysis.
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Actions of radiations on living cells. 2nd edition: By the late D. E. Lea, formerly Reader in Radiobiology in the University of Cambridge, England. Cambridge University Press, New York, N. Y., 1955. xiv + 416 pp. Price $6.00
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Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors.
TL;DR: In this paper, the authors investigated the mechanisms of zinc depletion-induced apoptosis, and concluded that cellular zinc inhibits apoptosis by maintaining caspase-3 inactive, without a requirement for an upstream event.
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Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions
TL;DR: It is concluded that S100A8/A9 exerts its apoptotic effect on two colon carcinoma cell lines through a dual mechanism: one via zinc exclusion from the target cells and the other through a yet‐undefined mechanism, probably relaying on the cell‐surface receptor(s).