On the Problem of Hidden Variables in Quantum Mechanics
Summary (2 min read)
Introduction
- Youth presenting for mental health care often have multiple symptoms and diagnoses, complicating the prescription of targeted treatment interventions.
- Indeed, recent examinations of data-rich brain connectivity images reveal meaningful associations between brain function and such data-driven, symptom-based classifications.
Participants and Measures
- The sample also included subjects who had a first-degree relative with bipolar disorder (“at risk” AR, n=35), and those with no psychopathology (healthy volunteers, HV, n=46).
- The copyright holder for this preprint (which wasthis version posted November 8, 2019.
- Thus, the current study contains data in an additional 112 subjects, beyond those appearing in this prior imaging paper.
- Comparisons among samples and results of this study, Kircanski et al, (2017) and Stoddard et al, (2017) are detailed in Supplementary Materials and Methods.
Latent Profile Analysis
- As in their original LPA (Kircanski et al, 2017), manifest variables in the LPA were separate parent- and child-reported ARI and SCARED scores, but only self-reported CDI and parent-reported CPRS scores.
- To be included in the LPA, a measure must have been collected within 60 days of scanning.
- As described in the introduction, the original analysis yielded a 5-class solution.
- Neural Response by Symptom Dimensions Differences in the number of classes reflect differences in the samples included in the current, vs. the original, LPA (Supplementary Materials and Methods).
Probability of Class Assignment
- Individuals differ in the in their goodness of fit to the classes identified by the group analysis (Figure 1).
- Mixture modeling, like the LPA used here, can account for this individual variation by providing the probability of an individual’s assignment to each class.
- Also, by using the probability of class assignment in their analysis, the authors can weigh the influence of each person on the results, making the analysis dimensional and hence more powerful.
- The authors denote this as Pclass overall or, for for use under a CC0 license.
- FMRI Task During fMRI, participants labelled the gender of happy, angry, and fearful face- emotion pictures from 10 actors (Ekman and Friesen, 1976).
Imaging Procedures
- Magnetic resonance images (MRI) were acquired on a General Electric 3.0 Tesla scanner with a 32-channel head coil.
- This work used the computational resources of the NIH HPC Biowulf cluster (http://hpc.nih.gov).
- The copyright holder for this preprint (which wasthis version posted November 8, 2019.
- EPI images were processed by removing the first four pre-magnetization volumes, limiting each voxel’s BOLD signal to four standard deviations from the mean trend of its time series, correcting for slice timing, affine volume to volume and volume to anatomic registration, smoothing using a 5 mm FWHM Gaussian kernel, and scaling to a mean of 100.
- Subjects were excluded if more than 15% of their volumes were censored or their mean censored volume to volume Euclidean displacement was more than or equal to 0.2mm (Table S1).
Analyses
- The ANOVA tested the fully interactive effects of each Probability of Class Assignment with Emotion and Intensity, except that no term could include an interaction between two or more .
- It is not subject to copyright under 17 USC 105 and is also made available not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
- For further descriptive analysis of each functional ROI, mean values of connectivity at each emotion by intensity were extracted via AFNI’s 3dROIstat.
- Any result no longer significant when influential subjects were removed was not reported.
Unique Associations of Amygdala Connectivity to Symptom Classes
- For regions showing unique associations between each symptom class and amygdala connectivity, see Table 2 and Figure 2.
- Increasing PIrr/ADHD was associated with decreased connectivity in response to 150% fearful and 150% angry faces, both relative to 150% happy (all p’s <.001).
- PIrr/ADHD also interacted with intensity to influence right amygdala connectivity to the bilateral precuneus (F1,1688=9.8, p<.001).
- Post hoc contrasts showed this interaction was significant at 50% intensity only.
- Post hoc analyses assessing the effects of medication for all regions of interest are presented in Table S3.
Discussion
- In a large, transdiagnostic clinical sample of youth, the authors aimed to identify neural correlates of empirically-defined symptom profiles.
- The copyright holder for this preprint (which wasthis version posted November 8, 2019.
- Page 15 of 27 is novel in applying task-based functional connectivity to validate a person-centered clustering of symptoms, which extends (Kircanski et al, 2017).
- Altogether, these studies converge to implicate aberrant amygdala function to clinical presentations involving both irritability and ADHD symptoms.
- It is not subject to copyright under 17 USC 105 and is also made available not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
Did you find this useful? Give us your feedback
Citations
[...]
6,949 citations
Cites background from "On the Problem of Hidden Variables ..."
...(68)] and the Clauser-Horne-Shimony-Holt (CHSH) form of Bell’s inequality (Bell, 1964; Clauser et al., 1969; Clauser and Shimony, 1978; Zeilinger, 1999):...
[...]
...In his 1991 paper Ekert suggested basing the security of this two-qubit protocol on Bell’s inequality, an inequality which demonstrates that some correlations predicted by quantum mechanics cannot be reproduced by any local theory (Bell, 1964)....
[...]
...In his 1991 paper Artur Ekert suggested to base the security of this 2-qubit protocol on Bell’s inequality, an inequality which demonstrates that some correlation predicted by quantum mechanics can’t be reproduced by any local theory (Bell 1964)....
[...]
6,887 citations
4,731 citations
3,080 citations
1,285 citations
References
10,253 citations
5,110 citations
605 citations
565 citations
451 citations
Related Papers (5)
Frequently Asked Questions (1)
Q1. What are the contributions in this paper?
The demonstrations of von Neumann and others, that quantum mechanics does not permit a hidden variable interpretation, are reconsidered this paper.