Journal ArticleDOI
On the size of the active site in proteases. I. Papain.
Israel Schechter,Arieh Berger +1 more
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This article is published in Biochemical and Biophysical Research Communications.The article was published on 1967-04-20. It has received 4865 citations till now. The article focuses on the topics: Proteases & PA clan.read more
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Journal ArticleDOI
Natural Products as Sources of New Drugs from 1981 to 2014
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This contribution is a completely updated and expanded version of the four prior analogous reviews that were published in this journal in 1997, 2003, 2007, and 2012, and the time frame has been extended to cover the 34 years from January 1, 1981, to December 31, 2014, for all diseases worldwide, and from 1950 (earliest so far identified) to December 2014 for all approved antitumor drugs worldwide.
Journal ArticleDOI
Molecular and Biotechnological Aspects of Microbial Proteases
TL;DR: Despite the extensive research on several aspects of proteases, there is a paucity of knowledge about the roles that govern the diverse specificity of these enzymes and deciphering these secrets would enable to exploit proteases for their applications in biotechnology.
Journal ArticleDOI
Purification and cloning of amyloid precursor protein beta-secretase from human brain.
Sukanto Sinha,John P. Anderson,Robin Barbour,Guriqbal S. Basi,Russell J. Caccavello,David Davis,Minhtam Doan,Harry F. Dovey,Normand Frigon,Jin Hong,Kirsten L. Jacobson-Croak,Nancy Jewett,Pamela S. Keim,J. Knops,Ivan Lieberburg,Michael Power,Hua Tan,Gwen Tatsuno,Jay Tung,Dale Schenk,Peter Seubert,Susanna Suomensaari,Shuwen Wang,Donald A. Walker,Jun Zhao,Lisa McConlogue,Varghese John +26 more
TL;DR: A membrane-bound enzyme activity that cleaves full-length APP at the β-secretase cleavage site is described and found to be the predominant β-cleavage activity in human brain, and it is found that human brain β- secretase is a new membrane- bound aspartic proteinase.
Journal ArticleDOI
Serine protease mechanism and specificity
TL;DR: This article will review recent work on the mechanism and specificity of chymotrypsin-like enzymes, with the occasional references to pertinent experiments with subtilisin.
Journal ArticleDOI
Targeting proteases: successes, failures and future prospects.
TL;DR: The status of human protease research and prospects for future protease-targeted drugs are reviewed, with reference to some key examples where protease drugs have succeeded or failed.
References
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Book ChapterDOI
Hydrolysis of Proteins
TL;DR: The chapter illustrates that the studies of hydrolytic agents have led to major advances in knowledge of proteins, including the identification of the amino acid constituents of proteins and the development of the polypeptide concept of protein structure.
Journal ArticleDOI
Structure of Some Crystalline Lysozyme-Inhibitor Complexes Determined by X-Ray Analysis At 6 Å Resolution
Louise N. Johnson,D. C. Phillips +1 more
TL;DR: In this paper, the structure of some Crystalline Lysozyme-Inhibitor Complexes was determined by X-Ray Analysis At 6 A Resolution, at 6 A resolution.
Journal ArticleDOI
Kinetics of proteinase action: application to specificity problems
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