Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
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TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
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miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF
TL;DR: In this paper, the role of miR-15a/16 in the angiogenesis of multiple myeloma (MM) was investigated using a stem-loop quantitative reverse transcription-PCR.
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A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo.
Bin Xu,Ninghan Feng,Pengchao Li,Jun Tao,Deyao Wu,Zhengdong Zhang,Na Tong,Jin-Feng Wang,Ninghong Song,Wei Zhang,Lixin Hua,Hong-Fei Wu +11 more
TL;DR: A G > C polymorphism which is located in the sequence of miR‐146a precursor, results in a change from a G:U pair to a C:U mismatch in its stem region and this polymorphism is analyzed for its role in prostate cancer risk.
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A Splicing-Independent Function of SF2/ASF in MicroRNA Processing
TL;DR: It is shown that SF2/ASF and one of its upregulated microRNAs (miR-7) can form a negative feedback loop: SF2 /ASF promotes miR- 7 maturation, and mature miR -7 in turn targets the 3'UTR of SF2-ASF to repress its translation.
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MYC translocation-negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation
Eleonora Leucci,Mario Cocco,Anna Onnis,G De Falco,P van Cleef,Cristiana Bellan,A.F. van Rijk,Joshua Nyagol,Bessie Byakika,Stefano Lazzi,Piero Tosi,H. van Krieken,Lorenzo Leoncini +12 more
TL;DR: The expression pattern of miRNAs predicted to target c‐Myc, in BL cases, is investigated to clarify whether alternative pathogenetic mechanisms may be responsible for lymphomagenesis in cases lacking the MYC translocation and indicates for the first time that hsa‐mir‐34b may influence c‐ myc expression in Burkitt lymphoma.
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Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth.
Xabier Agirre,Antonio Jiménez-Velasco,Edurne San José-Enériz,Leire Garate,Eva Bandrés,Lucia Cordeu,Oscar Aparicio,Borja Saez,German Navarro,Amaia Vilas-Zornoza,Ignacio Pérez-Roger,Jesús García-Foncillas,Antoni Torres,Anabel Heiniger,María José Calasanz,Puri Fortes,Jose Roman-Gomez,Felipe Prosper +17 more
TL;DR: The results indicate that down-regulation of hsa-miR-10a may increase USF2 and contribute to the increase in cell proliferation of CML implicating a miRNA in the abnormal behavior of C ML.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
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