Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
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TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
Citations
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miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma
Alexander Swarbrick,Alexander Swarbrick,Susan L. Woods,Susan L. Woods,Alex D. Shaw,Alex D. Shaw,Alex D. Shaw,Asha Balakrishnan,Yuwei Phua,Yuwei Phua,Akira Nguyen,Yvan Chanthery,Lionel Lim,Lesley J. Ashton,Robert L. Judson,Noelle E. Huskey,Robert Blelloch,Michelle Haber,Murray D. Norris,Peter Lengyel,Christopher S. Hackett,Thomas Preiss,Thomas Preiss,Albert Chetcuti,Christopher S. Sullivan,Eric G. Marcusson,William A. Weiss,Noelle D. L'Etoile,Andrei Goga +28 more
TL;DR: A new mechanism of p53 regulation in cancer and stem cells is demonstrated and a potential therapeutic target for neuroblastoma is uncovered.
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Electrochemical determination of microRNA-21 based on graphene, LNA integrated molecular beacon, AuNPs and biotin multifunctional bio bar codes and enzymatic assay system.
TL;DR: A highly sensitive biosensor for sequence specific mi RNA-21 detection without miRNA-21 labeling and enrichment was constructed based on the substrate electrode of dendritic gold nanostructure and graphene nanosheets modified glassy carbon electrode and showed excellent selectivity and high sensitivity with low detection limit of 0.06 pM.
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Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis.
S Marton,M R Garcia,Carlos Robello,Helena Persson,Felipe Trajtenberg,Otto Pritsch,Carlos Rovira,Hugo Naya,Guillermo Dighiero,Alfonso Cayota +9 more
TL;DR: The results showed a global reduction in miRNA expression levels in CLL cells associated to a consistent underexpression of miR-181a, let-7a andmiR-30d, and five novel miRNA candidates cloned from leukemic cells are reported.
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Competing endogenous RNA networks: tying the essential knots for cancer biology and therapeutics
TL;DR: The most recent discoveries that implicate natural miRNA decoys in human cancer biology are discussed, as well as exciting advances in the study of ceRNA networks and dynamics.
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Human microRNA oncogenes and tumor suppressors show significantly different biological patterns: from functions to targets.
TL;DR: This study represents the first large-scale bioinformatic analysis of human miRNA oncogenes and tumor suppressors and indicates that these two types of cancer-associated miRNAs play different roles in cancer formation and development.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
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