Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
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TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:Â
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
Citations
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E2F1-Regulated MicroRNAs Impair TGFb-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer
Fabio Petrocca,Rosa Visone,Mariadele Rapazzotti Onelli,Manisha H. Shah,Milena S. Nicoloso,Ivana De Martino,Dimitrios Iliopoulos,Emanuela Pilozzi,Chang Gong Liu,Massimo Negrini,Luigi Cavazzini,Stefano Volinia,Hansjuerg Alder,Luigi P. Ruco,Gustavo Baldassarre,Carlo M. Croce,Andrea Vecchione +16 more
TL;DR: Evidence is provided that the miR-106b-25 cluster, upregulated in a subset of human gastric tumors, is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGFbeta resistance in gastric cancer.
Journal ArticleDOI
The Role of Non-coding RNAs in Oncology
TL;DR: For decades, research into cancer biology focused on the involvement of protein-coding genes, but an explosion of studies into ncRNA biology has shown that they represent a diverse and prevalent group of RNAs, including both oncogenic molecules and those that work in a tumor suppressive manner.
Journal ArticleDOI
MicroRNA expression and function in cancer
TL;DR: Large high-throughput studies in patients revealed that miRNA profiling have the potential to classify tumors with high accuracy and predict outcome and the role of miRNAs in the pathogenesis of cancer is examined.
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MiR-15a and miR-16-1 cluster functions in human leukemia.
George A. Calin,Amelia Cimmino,Muller Fabbri,Manuela Ferracin,Sylwia E. Wojcik,Masayoshi Shimizu,Cristian Taccioli,Nicola Zanesi,Ramiro Garzon,Rami I. Aqeilan,Hansjuerg Alder,Stefano Volinia,Laura Z. Rassenti,Xiuping Liu,Chang Gong Liu,Thomas J. Kipps,Massimo Negrini,Carlo M. Croce +17 more
TL;DR: A high-throughput profiling of genes modulated by miR-15a/16-1 in a leukemic cell line model (MEG-01) and in primary CLL samples is produced and a significant enrichment in cancer genes that directly or indirectly affect apoptosis and cell cycle was found.
Journal ArticleDOI
MicroRNA functions in stress responses.
TL;DR: This work has shown that miRNAs play key roles in fundamental cellular processes, including how cells respond to changes in environment or stresses, and dysregulation of these processes contributes to chronic diseases, including cancers.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof RÃ¥dmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
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MicroRNA expression profiles classify human cancers
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