Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
Reads0
Chats0
TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
Citations
More filters
Journal ArticleDOI
miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer
Brian D. Adams,Vikram B. Wali,Christopher J. Cheng,Sachi Inukai,Carmen J. Booth,Seema Agarwal,David L. Rimm,Balázs Győrffy,Libero Santarpia,Lajos Pusztai,W. Mark Saltzman,Frank J. Slack +11 more
TL;DR: It is demonstrated that miR-34a exerts potent antitumorigenic effects in vitro and in vivo and suggests thatmiR- 34a replacement therapy, which is currently being tested in human clinical trials, represents a promising therapeutic strategy for TNBC.
Journal ArticleDOI
A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk
Rongxi Yang,Rongxi Yang,B. Schlehe,Kari Hemminki,Kari Hemminki,Christian Sutter,Peter Bugert,Barbara Wappenschmidt,Juliane Volkmann,Raymonda Varon,Bernhard H. F. Weber,Dieter Niederacher,Norbert Arnold,Alfons Meindl,Claus R. Bartram,Rita K. Schmutzler,Barbara Burwinkel,Barbara Burwinkel +17 more
TL;DR: It is hypothesized that the G-variant of rs895819 might impair the maturation of the oncogenic miR-27a and thus, is associated with familial breast cancer risk.
Journal ArticleDOI
The role of microRNAs in cancer: diagnostic and prognostic biomarkers and targets of therapies
Lidia Rita Corsini,Giuseppe Bronte,Marianna Terrasi,Valeria Amodeo,Daniele Fanale,Eugenio Fiorentino,Giuseppe Cicero,Viviana Bazan,Antonio Russo +8 more
TL;DR: Both miRNA expression profiles in cancer tissues and miRNA levels in peripheral blood were studied for improvement in the management of cancer patients and the potential for better understanding of tumor biology was found.
Journal ArticleDOI
Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development
TL;DR: Recent progresses that have identified a myriad of molecular functions on tumorigenesis for several lncRNAs including metastasis-associated lung adenocarcinoma transcript 1, prostate cancer associated non-coding RNA 1 (PRNCR1), prostate cancer gene expression marker 1 (PCGEM1), H19, and homeobox transcript antisense intergenic RNA (HOTAIR), and several new lnc RNAs for glioma development are highlighted.
Journal ArticleDOI
Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesis
TL;DR: Over the next decade with the exciting new genomic approaches to epigenome analysis and the initiation of a Human Epigenome Project, more will be understood about the interplay between DNA methylation and chromatin modifications and the expression of non-coding RNAs, promising a new range of molecular diagnostic cancer markers and molecular targets for cancer epigenetic therapy.
References
More filters
Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
Related Papers (5)
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more