Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
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TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
Citations
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Dedifferentiation and reprogramming: origins of cancer stem cells
TL;DR: The similarities between tumor dedifferentiation and somatic cell reprogramming are discussed and how this may pose a risk to the application of this new technology in regenerative medicine.
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MicroRNA Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus: Associations with Survival
Ewy Mathé,Giang Nguyen,Elise D. Bowman,Yiqiang Zhao,Yiqiang Zhao,Anuradha Budhu,Aaron J. Schetter,Rosemary Braun,Mark Reimers,Kensuke Kumamoto,Duncan B. Hughes,Nasser K. Altorki,Alan G. Casson,Chang Gong Liu,Xin Wei Wang,Nozomu Yanaihara,Nobutoshi Hagiwara,Andrew J. Dannenberg,Masao Miyashita,Carlo M. Croce,Curtis C. Harris +20 more
TL;DR: Evaluated miRNAs involved in major histologic types of esophageal carcinoma and uncover significant associations with prognosis were independent of tumor stage or nodal status, cohort type, and chemoradiation therapy.
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Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells.
TL;DR: Observations suggest that modulation of miRNA expression may be an important mechanism underlying the biological effects of curcumin.
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MiR-26a Inhibits Cell Growth and Tumorigenesis of Nasopharyngeal Carcinoma through Repression of EZH2
Juan Lu,Ming-Liang He,Lu Wang,Ying Chen,Xiong Liu,Qi Dong,Yangchao Chen,Ying Peng,Kaitai Yao,Hsiang-Fu Kung,Xiang-Ping Li +10 more
TL;DR: The results indicate that miR-26a functions as a growth-suppressive miRNA in NPC, and that its suppressive effects are mediated chiefly by repressing EZH2 expression.
Journal ArticleDOI
Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92.
H Matsubara,Toshiyuki Takeuchi,Eri Nishikawa,Kiyoshi Yanagisawa,Yoji Hayashita,Hiromichi Ebi,Hiroyuki Yamada,Motoshi Suzuki,Masato Nagino,Yuji Nimura,Hirotaka Osada,Takashi Takahashi +11 more
TL;DR: It is shown that inhibition of miR-17-5p andMiR-20a with antisense oligonucleotides (ONs) can induce apoptosis selectively in lung cancer cells overexpressing miR -17-92, suggesting the possibility of ‘OncomiR addiction’ to expression of these miRNAs in a subset of lung cancers.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
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