Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
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TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
Citations
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Semi-supervised learning for potential human microRNA-disease associations inference
Xing Chen,Guiying Yan +1 more
TL;DR: Regularized Least Squares for MiRNA-Disease Association (RLSMDA) is developed to uncover the relationship between diseases and miRNAs and is a semi-supervised and global method (prioritize associations for all the diseases simultaneously).
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miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis
Avital Gaziel-Sovran,Miguel F. Segura,Raffaella Di Micco,Mary K. Collins,Douglas Hanniford,Eleazar Vega-Saenz de Miera,John F. Rakus,John F. Dankert,Shulian Shang,Robert S. Kerbel,Nina Bhardwaj,Yongzhao Shao,Farbod Darvishian,Jiri Zavadil,Adrian Erlebacher,Lara K. Mahal,Iman Osman,Eva Hernando +17 more
TL;DR: A microRNA analysis of human melanoma found that miR-30b/30d upregulation correlates with stage, metastatic potential, shorter time to recurrence, and reduced overall survival, and these data support a key role of miR/30D and GalNAc transferases in metastasis, by simultaneously promoting cellular invasion and immunosuppression.
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Lab in a Tube: Ultrasensitive Detection of MicroRNAs at the Single-Cell Level and in Breast Cancer Patients Using Quadratic Isothermal Amplification
Ruixue Duan,Xiaolei Zuo,Shutao Wang,Xiyun Quan,Dongliang Chen,Zhifei Chen,Lei Jiang,Chunhai Fan,Fan Xia +8 more
TL;DR: A one-pot hairpin-mediated quadratic enzymatic amplification strategy for microRNA (miRNA) detection that is sensitive and selective when applied to crude extractions from MCF-7 and PC3 cell lines and even patient tissues from intraductal carcinomas and invasive ductal carcinoma of the breast.
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DNA methylomes, histone codes and miRNAs: Tying it all together
Sonia Guil,Manel Esteller +1 more
TL;DR: In this review, increasing evidence has indicated that a substantial number of microRNA genes are subjected to epigenetic alterations, resulting in aberrant patterns of expression upon the occurrence of cancer.
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MicroRNAs and their roles in aging
TL;DR: How certain miRNAs can regulate aging on the level of organism lifespan, tissue aging or cellular senescence is highlighted and future approaches that might be used to investigate the mechanisms by which mi RNAs govern aging processes are discussed.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
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