Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
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TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
Citations
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Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues
Angela B.Y. Hui,Wei Shi,Paul C. Boutros,Naomi Miller,Melania Pintilie,Tony Fyles,Tony Fyles,David R. McCready,Derek Wong,Kate Gerster,Igor Jurisica,Igor Jurisica,Linda Z. Penn,Linda Z. Penn,Fei-Fei Liu +14 more
TL;DR: The results show the validity and utility of conducting global miR profiling using FFPE samples, thereby offering enormous opportunities to evaluate archival banks of such materials, linked to clinical databases, to rapidly acquire greater insight into the clinically relevant role for miRs in human malignancies.
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MicroRNA-221 Induces Cell Survival and Cisplatin Resistance through PI3K/Akt Pathway in Human Osteosarcoma
Guangyi Zhao,Chengkui Cai,Tongtao Yang,Xiuchun Qiu,Bo Liao,Wei Li,Zhenwei Ji,Jian Zhao,Haien Zhao,Mingjun Guo,Qiong Ma,Chun Xiao,Qingyu Fan,Baoan Ma +13 more
TL;DR: It is demonstrated for the first time that upregulation of miR-221 induces the malignant phenotype of human osteosarcoma whereas knockdown of mi R-221 reverses this phenotype, suggesting that miR -221 could be a potential target for osteosARcoma treatment.
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Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3
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TL;DR: The deregulation of the expression of the let-7 family of miRNAs by HBx may represent a potential novel pathway through which HBx acts to deregulate cell proliferation leading to hepatocarcinogenesis.
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Initial study of microRNA expression profiles of colonic cancer without lymph node metastasis
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Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI.
Yi Ping Yang,Yueh Chien,Guang-Yuh Chiou,Guang-Yuh Chiou,Jong Yuh Cherng,Mong Lien Wang,Wen Liang Lo,Yuh Lih Chang,Pin I. Huang,Yi Wei Chen,Yang Hsin Shih,Ming Teh Chen,Shih Hwa Chiou +12 more
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References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
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