One-Carbon Metabolism in Health and Disease
Reads0
Chats0
TLDR
The fundamentals of mammalian 1C metabolism, including the pathways active in different compartments, cell types, and biological states, are reviewed and new opportunities for selective therapeutic intervention are highlighted.About:
This article is published in Cell Metabolism.The article was published on 2017-01-10 and is currently open access. It has received 1126 citations till now. The article focuses on the topics: Amino acid homeostasis & Serine.read more
Citations
More filters
Journal ArticleDOI
Oxidative Stress in Cancer.
TL;DR: During progression and metastasis, tumor cells adapt to oxidative stress by increasing NADPH in various ways, including activation of AMPK, the PPP, and reductive glutamine and folate metabolism.
Journal ArticleDOI
The multifaceted contributions of mitochondria to cellular metabolism.
TL;DR: This Review discusses how mitochondria catabolize nutrients for energy, generate biosynthetic precursors for macromolecules, compartmentalize metabolites for the maintenance of redox homeostasis and function as hubs for metabolic waste management.
Journal ArticleDOI
Circadian physiology of metabolism.
TL;DR: These findings highlight an integrative role of circadian rhythms in physiology and offer a new perspective for treating chronic diseases in which metabolic disruption is a hallmark.
Journal ArticleDOI
Metabolic regulation of cell growth and proliferation.
Jiajun Zhu,Craig B. Thompson +1 more
TL;DR: A better understanding of how cells utilize nutrients for biosynthetic pathways and how they overcome the metabolic challenges associated with high proliferation rates can lead to better control of cell proliferation and improved cancer treatments.
References
More filters
Journal ArticleDOI
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang,David W. White,Stefan Gross,Bryson D. Bennett,Mark A. Bittinger,Edward M. Driggers,Valeria Fantin,Hyun Gyung Jang,Shengfang Jin,Marie C. Keenan,Kevin Marks,Robert M. Prins,Patrick S. Ward,Katharine E. Yen,Linda M. Liau,Joshua D. Rabinowitz,Lewis C. Cantley,Craig B. Thompson,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Shinsan M. Su +20 more
TL;DR: It is shown that cancer-associated IDH1 mutations result in a new ability of the enzyme to catalyse the NADPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG), and that the excess 2HG which accumulates in vivo contributes to the formation and malignant progression of gliomas.
Journal ArticleDOI
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Arun Sreekumar,Laila M. Poisson,Thekkelnaycke M. Rajendiran,Amjad Khan,Qi Cao,Jindan Yu,Bharathi Laxman,Rohit Mehra,Robert J. Lonigro,Yong Li,Mukesh K. Nyati,Aarif Ahsan,Shanker Kalyana-Sundaram,Bo Han,Xuhong Cao,Jaeman Byun,Gilbert S. Omenn,Debashis Ghosh,Subramaniam Pennathur,Danny C. Alexander,Alvin Berger,Jeffrey R. Shuster,John T. Wei,Sooryanarayana Varambally,Christopher A. Beecher,Arul M. Chinnaiyan +25 more
TL;DR: Sarcosine, an N-methyl derivative of the amino acid glycine, was identified as a differential metabolite that was highly increased during prostate cancer progression to metastasis and can be detected non-invasively in urine.
Journal ArticleDOI
Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis
TL;DR: Whether the association of serum homocysteine concentration with ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke is causal and, if so, to quantify the effect of homocy Steine reduction in preventing them, there is strong evidence that the association between homocy steine and cardiovascular disease is causal.
Journal ArticleDOI
Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
Eva Lonn,Salim Yusuf,J.M. Arnold,Janice Pogue,Mary Micks,Matthew J. McQueen,Jeffrey L. Probstfield +6 more
TL;DR: Supplements combining folic acid and vitamins B6 and B12 did not reduce the risk of major cardiovascular events in patients with vascular disease.
Journal ArticleDOI
Methionine metabolism in mammals.
TL;DR: Article de synthese sur le metabolisme de la methionine, acide amine essentiel, chez les mammiferes, de la regulation du metabolisme (mise en evidence and importance relative of chaque facteur).
Related Papers (5)
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
Richard Possemato,Kevin Marks,Yoav D. Shaul,Michael E. Pacold,Dohoon Kim,Kıvanç Birsoy,Shalini Sethumadhavan,Hin-Koon Woo,Hyun Gyung Jang,Abhishek K. Jha,Walter W. Chen,Francesca G. Barrett,Nicolas Stransky,Zhi-Yang Tsun,Glenn S. Cowley,Jordi Barretina,Jordi Barretina,Nada Y. Kalaany,Peggy P. Hsu,Kathleen Ottina,Albert M. Chan,Bingbing Yuan,Levi A. Garraway,Levi A. Garraway,David E. Root,Mari Mino-Kenudson,Elena F. Brachtel,Edward M. Driggers,David M. Sabatini +28 more