Journal Article•
One New and Two Rare Alkamides from Two Samples of the Fruits of Piper longum
TL;DR: In this paper, two samples of the fruits of Piper longum have been chemically investigated and two rare alkamides, brachystamide B and piperderdine have been isolated.
Abstract: Two samples of the fruits of Piper longum have been chemically investigated. From one sample a new alkamide, pergumidiene and from other sample two rare alkamides, brachystamide B and piperderdine have been isolated. The known compounds, piperine, piperlonguminine, pellitorine, (+)-sesamine and 3-(3', 4', 5'-trimethoxyphenyl)-propionic acid were the common constituents of both the samples.
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TL;DR: All the isolates of Piper longum had antibacterial activity except 3-(3'-4'-5'-trimethoxyphenyl) propionicacid (4), whereas isolate of T. baccata showed moderate activity.
Abstract: This study describes the antibacterial activity of the pure isolates from Piper longum (L.) (black pepper) and Taxus baccata (L.) (Yew). Three isolates of black pepper were active against Gram-posi...
170 citations
Cites background from "One New and Two Rare Alkamides from..."
...The following compounds were eluted according to the increasing polarity: pellitorine (3) (147mg), piperlonguminine (1) (110mg), piperine (2) (138mg) and 3- (3¢-4¢-5¢-trimethoxyphenyl) propionicacid (4) (408mg) (Das et al., 1998a)....
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...The following compounds were eluted according to the increasing order of polarity: (-)-rhododendrol (5) (256mg), 4-(4¢-hydroxyphenyl)-butan-2-one (6) (43mg) and 4-(4¢- hydroxyphenyl)-trans-but-3-en-2-one (7) (32mg) (Das et al., 1998b)....
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TL;DR: The n-hexane extracts of 19 Piper species, predominantly from China, were screened for their 5-lipoxygenase (5-LOX) and cyclo oxygengenase-1 (COX-1) inhibitory potential and showed considerable inhibitory activity against at least one of these two key enzymes of the arachidonic acid metabolism.
152 citations
TL;DR: A reversed-phase high-performance liquid chromatography method was developed to quantify these active principles in the plant material, which can serve as an effective quality control tool.
40 citations
01 May 2011
TL;DR: Piper, the pepper plants or pepper vines are an economically and ecologically important genus in the family Piperaceae, which contains about 1,000-2,000 species of shrubs, herbs, and lianas, many of which are keystone species in their native habitat.
Abstract: Piper, the pepper plants or pepper vines are an economically and ecologically important genus in the family Piperaceae. It contains about 1,000-2,000 species of shrubs, herbs, and lianas, many of which are keystone species in their native habitat. Piper species have a pan tropical distribution, and are most commonly found in the understory of lowland tropical rainforests, but can also occur in clearings and in higher elevation life zones such as cloud forests. Most Piper species are either herbaceous or vines; some grow as shrubs or almost as small trees. Many species of piper have been used for treating different diseases in many traditions. E.g P. cubeba has been used in folk medicine, herbalism as well as in the early 20th century, as a cigarette flavoring. P. darienense is used medically by the Kuna people of the Panama-Colombia border region, and elsewhere it is used to intoxicate fish which then can be easily caught. Black Pepper (P. nigrum) essential oil is sometimes used in herbalism, and Long Pepper (P. longum) is similarly employed in Ayurveda, where it was an ingredient of Triphala Guggulu and (together with Black Pepper) of Trikatu pills, used for rasayana (rejuvenating and detoxifying) purposes.
28 citations
Patent•
01 Oct 2004
TL;DR: In this article, mixtures of at least four of the alkadienamides defined according to the structure are described, where R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen.
Abstract: Described are mixtures of at least four of the alkadienamides defined according to the structure:
wherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formula —(CH 2 ) n —, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
22 citations