One-step optogenetics with multifunctional flexible polymer fibers
Seongjun Park,Yuanyuan Guo,Xiaoting Jia,Han Kyoung Choe,Benjamin Jean-baptiste Grena,Jeewoo Kang,Jiyeon Park,Chi Lu,Andres Canales,Ritchie Chen,Yeong Shin Yim,Gloria B. Choi,Yoel Fink,Polina Anikeeva +13 more
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TLDR
In this paper, a device composed of an optical waveguide, six electrodes and two microfluidic channels produced via fiber drawing was used to deliver light-sensitive opsins into tissue and subsequent optical illumination and electrical recording from the regions of interest.Abstract:
Optogenetic interrogation of neural pathways relies on delivery of light-sensitive opsins into tissue and subsequent optical illumination and electrical recording from the regions of interest. Despite the recent development of multifunctional neural probes, integration of these modalities in a single biocompatible platform remains a challenge. We developed a device composed of an optical waveguide, six electrodes and two microfluidic channels produced via fiber drawing. Our probes facilitated injections of viral vectors carrying opsin genes while providing collocated neural recording and optical stimulation. The miniature (<200 μm) footprint and modest weight (<0.5 g) of these probes allowed for multiple implantations into the mouse brain, which enabled opto-electrophysiological investigation of projections from the basolateral amygdala to the medial prefrontal cortex and ventral hippocampus during behavioral experiments. Fabricated solely from polymers and polymer composites, these flexible probes minimized tissue response to achieve chronic multimodal interrogation of brain circuits with high fidelity.read more
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Electronic Skin: Recent Progress and Future Prospects for Skin‐Attachable Devices for Health Monitoring, Robotics, and Prosthetics
TL;DR: Recent progress in electronic skin or e‐skin research is broadly reviewed, focusing on technologies needed in three main applications: skin‐attachable electronics, robotics, and prosthetics.
Journal ArticleDOI
3D printing of conducting polymers.
TL;DR: A high-performance 3D printable conducting polymer ink based on poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) for 3D printing of conducting polymers is introduced to take full advantage of advanced3D printing.
Journal ArticleDOI
Smart Textile-Integrated Microelectronic Systems for Wearable Applications
Jidong Shi,Su Liu,Lisha Zhang,Bao Yang,Lin Shu,Ying Yang,Ming Ren,Yang Wang,Jiewei Chen,Wei Chen,Yang Chai,Xiaoming Tao +11 more
TL;DR: The programmable nature of smart textiles makes them an indispensable part of an emerging new technology field and a timely overview and comprehensive review of progress of this field in the last five years are provided.
Journal ArticleDOI
High-performance stretchable conductive nanocomposites: materials, processes, and device applications
TL;DR: The recent advances in stretchable conductors based on the percolation networks of nanoscale conductive fillers in elastomeric media are summarized and various techniques that are used to reduce the contact resistance between the conductive filler materials are highlighted.
Journal ArticleDOI
Novel electrode technologies for neural recordings.
Guosong Hong,Charles M. Lieber +1 more
TL;DR: It is described how these emergent neurotechnologies can approach the ultimate goal of illuminating chronic brain activity with minimal disruption of the neural environment, thereby providing unprecedented opportunities for neuroscience research in the future.
References
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The Mouse Brain in Stereotaxic Coordinates
TL;DR: The 3rd edition of this atlas is now in more practical 14"x11" format for convenient lab use and includes a CD of all plates and diagrams, as well as Adobe Illustrator files of the diagrams, and a variety of additional useful material.
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Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
Journal ArticleDOI
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.
Georg Nagel,Tanjef Szellas,Wolfram Huhn,Suneel Kateriya,Nona Adeishvili,Peter Berthold,Doris Ollig,Peter Hegemann,Ernst Bamberg +8 more
TL;DR: It is demonstrated by functional expression, both in oocytes of Xenopus laevis and mammalian cells, that ChR2 is a directly light-switched cation-selective ion channel, and may be used to depolarize small or large cells, simply by illumination.
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Polymer Data Handbook
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