Journal ArticleDOI
Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.
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TLDR
Six stages of oocyte development in the anuran Xenopus laevis can be divided into six stages based on the anatomy of the developing oocyte, and these stages have been correlated with physiological and biochemical data related to oogenesis.Abstract:
Oogenesis in the anuran Xenopus laevis can be divided into six stages based on the anatomy of the developing oocyte. Stage I consists of small (50 to 100 μ) colorless oocytes whose cytoplasm is transparent. Their large nuclei and mitochondrial masses are clearly visible in the intact oocyte. Stage II oocytes range up to 450 μ in diameter, and appear white and opaque. Stage I and II are both previtellogenic. Pigment synthesis and yolk accumulation (vitellogenesis) begins during Stage III. Vitellogenesis continues through Stage IV (600 to 1000 μ), the oocytes grow rapidly, and the animal and vegetal hemispheres become differentiated. By Stage V (1000 to 1200 μ) the oocytes have nearly reached their maximum size and yolk accumulation gradually ceases. Stage VI oocytes are characterized by the appearance of an essentially unpigmented equatorial band. They range in size from 1200 to 1300 μ, are postivtellogenic and ready for ovulation. These stages of oocyte development have been correlated with physiological and biochemical data related to oogenesis in Xenopus.read more
Citations
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A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel
TL;DR: The finding that HERG encodes IKr channels provides a mechanistic link between certain forms of inherited and acquired LQT, and that an additional subunit may be required for drug sensitivity.
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Control of the peroxisomal beta- oxidation pathway by a novel family of nuclear hormone receptors
Christine Dreyer,Grigorios Krey,Hansjörg Keller,Françoise Givel,Gerd Helftenbein,Walter Wahli +5 more
TL;DR: Three novel members of the Xenopus nuclear hormone receptor superfamily have been cloned and their multiplicity suggests the existence of hitherto unknown cellular signaling pathways for xenobiotics and putative endogenous ligands.
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Molecular basis of mechanotransduction in living cells
Owen P. Hamill,Boris Martinac +1 more
TL;DR: The simplest cell-like structure, the lipid bilayer vesicle, can respond to mechanical deformation by elastic membrane dilation/thinning and curvature changes and changes in local membrane curvature may shift the equilibrium between channel conformations.
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A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
TL;DR: A 1,957 amino-acid sodium channel is identified in dorsal root ganglion sensory neurons associated with C-fibres that shows 65% identity with the rat cardiac tetrodotoxin-insensitive sodium channel, and is not expressed in other peripheral and central neurons, glia or non-neuronal tissues.
Journal ArticleDOI
Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes.
TL;DR: It is shown that both the size and shape of the amphibian oocyte nucleolus ultimately arise because nucleoli behave as liquid-like droplets of RNA and protein, exhibiting characteristic viscous fluid dynamics even on timescales of < 1 min.
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TL;DR: Animal tissue techniques, Animal tissue techniques , مرکز فناوری اطلاعات و اصاع رسانی, کδاوρزی
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A method for staining epoxy sections for light microscopy.
TL;DR: A technique for staining sections of osmium-fixed, epoxy-embedded tissues for light microscopy using aqueous toluidine blue at pH 11.1 and does not require prior removal of embedding medium, which permits better utilization of the full resolving power of the light microscope.
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The fine structure of the gastric mucosa in the bat.
Susumu Ito,Robert J. Winchester +1 more
TL;DR: The fine structure of the various cell types in this species is fundamentally similar to that of the corresponding cell types of other mammals, but the relative cell numbers and distribution are somewhat different.