OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
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3,340 citations
Cites background from "OPA1 Controls Apoptotic Cristae Rem..."
...Moreover, recent work suggests that the junctions between ICS and IMS are maintained by Opa1 (optic atrophia 1) (226), an integral protein of the IM with established roles in mitochondrial dynamics (113, 605)....
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...These oligomers may constitute (part of) the structure that preserves the junctions between ICS and IMS in a bottleneck configuration (136, 226)....
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3,301 citations
2,266 citations
Cites background from "OPA1 Controls Apoptotic Cristae Rem..."
...These junctions are restructured during apoptosis to facilitate release of proapoptotic intermembrane space proteins (Frezza et al., 2006)....
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...This protection is in part due to the role of OPA1 in the integrity of crista junctions and its ability to limit the release of proapoptotic IMS components (Cipolat et al., 2006; Frezza et al., 2006)....
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2,219 citations
Cites background from "OPA1 Controls Apoptotic Cristae Rem..."
...Two IMS proteins, optic atrophy protein 1 ( OPA1 ; a dynamin-like GTPase) and presenilins-associated rhomboid-like protein ( PARL ; a rhomboid protease) have been found to regulate cristae remodelling during apoptosi...
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2,027 citations
References
3,942 citations
"OPA1 Controls Apoptotic Cristae Rem..." refers background in this paper
...Expression of wild-type (wt) OPA1 protected mouse embryonic fibroblasts (MEFs) from death induced by apoptotic stimuli that activate the mitochondrial pathway like H2O2, etoposide, staurosporine, and truncated, active BID (tBID) (Wei et al., 2001; Scorrano et al., 2003) (Figures 1A–1D)....
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3,258 citations
"OPA1 Controls Apoptotic Cristae Rem..." refers background in this paper
...Cell 126, 177–189, July 14, 2006 ª2006 Elsevier Inc. 185 cytochrome c release and complete the program of mitochondrial dysfunction (Green and Kroemer, 2004)....
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...In a widely accepted model, these proteins can form a channel for the efflux of cytochrome c across the outer mitochondrial membrane (Green and Kroemer, 2004)....
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...Mitochondria amplify apoptosis induced by several stimuli (Green and Kroemer, 2004)....
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...cytochrome c release and complete the program of mitochondrial dysfunction (Green and Kroemer, 2004)....
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3,147 citations
"OPA1 Controls Apoptotic Cristae Rem..." refers background in this paper
...In type I cells, death receptors directly activate effector caspases, bypassing the mitochondrial amplificatory loop (Scaffidi et al., 1998)....
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2,439 citations
"OPA1 Controls Apoptotic Cristae Rem..." refers background in this paper
...They release cytochrome c and other proapoptotic proteins activating a postmitochondrial pathway that culminates in cell demise (Wang, 2001)....
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2,239 citations
"OPA1 Controls Apoptotic Cristae Rem..." refers background in this paper
...Mitofusin (MFN) -1 and -2 are dynamin-related proteins of the outer membrane (OM) essential for mitochondrial tethering and fusion (Santel and Fuller, 2001; Legros et al., 2002; Santel et al., 2003; Chen et al., 2003)....
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