Opioid substitution and antagonist therapy trials exclude the common addiction patient: a systematic review and analysis of eligibility criteria
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140 citations
Cites background from "Opioid substitution and antagonist ..."
...The reasons for this large divergence are unclear, but may include differences between samples owing to study exclusion criteria [73,74] and a host of procedural differences between investigational studies and routine clinical care (e....
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44 citations
Cites background from "Opioid substitution and antagonist ..."
...Furthermore, many randomized controlled trials have limited generalizability to real-world practice, because they often exclude patients who have comorbid psychiatric disorders (13)....
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44 citations
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27 citations
Cites background from "Opioid substitution and antagonist ..."
...Such high-need, medically comorbid or unstable populations are typically excluded from national surveys of BHDs in the general, non-institutionalized population and clinical trials due to safety consideration or study-specific exclusion criteria (Dennis et al., 2015; Lind, 2011)....
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References
34,965 citations
"Opioid substitution and antagonist ..." refers background or methods in this paper
...We used the kappa statistic to assess inter-rater agreement, [43], which is preferable to percent agreement calculations since it takes into account any agreement occurring by chance....
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...Kappa values range from 0 to 1, with values closer to 1 indicating a higher level of agreement [43]....
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25,711 citations
"Opioid substitution and antagonist ..." refers methods in this paper
...This review adheres to the reporting standards set out by the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines [44]....
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19,347 citations
"Opioid substitution and antagonist ..." refers methods in this paper
...(MINI) [47] to assess for psychiatric comorbidities, and the Maudsley Addiction Profile (MAP) instrument to...
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...Changes made following the pilot phase include: relaxing eligibility criteria, utilizing a prospective cohort design with a follow-up duration of 12 months, and integrating the use of validated tools such as the Brief Pain Inventory (BPI) to assess pain [46], the Mini International Neuropsychiatric Interview version 6.0 (MINI) [47] to assess for psychiatric comorbidities, and the Maudsley Addiction Profile (MAP) instrument to assess addiction severity across personal, physical, and social functioning domains [48]....
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...Depending on the thoroughness of the trial investigators and indeed the thoroughness of the clinicians administering the GENOA assessment tools (MINI, BPI, MAP), differing rates of psychiatric problems will be identified and could compromise the aims of our study....
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...However, we maintain important variables, such as psychiatric comorbidity, were ascertained using a validated questionnaire, the MINI....
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...(PDF 262 kb) Abbreviations AGREE: Appraisal of Guidelines for Research and Evaluation; ASI: Addiction Severity Index; BPI: Brief Pain Inventory; CATC: Canadian Addiction Treatment Centres; CI: confidence interval; CTR: Clinical Trials Registry; DSM-IV: Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; EMBASE: Excerpta Medica DataBase; FDA: Food and Drug Administration; GENOA: Genetics of Opioid Addiction; GRADE: Grading of Recommendations Assessment, Development and Evaluation; HIV: human immunodeficiency virus; HR: hazard ratio; ICD: International Classification of Disease; LAAM: levo-α-acetylmethadol; MAP: Maudsley Addiction Profile; MINI: The Mini International Neuropsychiatric Interview; MMT: methadone maintenance treatment; NICE: National Institute for Health and Care Excellence; NIH: National Institutes of Health; OATC: Ontario Addiction Treatment Centres; OSAT: opioid substitution and antagonist therapy; OST: opioid substitution therapy; PRISMA: Preferred Reporting Items for Systematic reviews and Meta-Analyses; RCT: randomized controlled trial; SD: standard deviation; SE: standard error; WHO: World Health Organization; UK: United Kingdom; US: United States....
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13,813 citations
"Opioid substitution and antagonist ..." refers methods in this paper
...This review adheres to the reporting standards set out by the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines [44]....
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9,769 citations