Optic Vesicle-like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment
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...…including photoreceptors and retinal pigment epithelium, from pluripotent stem cells (Boucherie et al., 2011; Lund et al., 2006; Lu et al., 2009a; Meyer et al., 2011; Osakada et al., 2008; Idelson et al., 2009; Lamba et al., 2006, 2010; Carr et al., 2009; Ikeda et al., 2005; Kawasaki et al.,…...
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...Much progress has been made over the last decade in understanding the molecular mechanism of cellular differentiation, enabling in vitro generation of retinal cells, including photoreceptors and retinal pigment epithelium, from pluripotent stem cells (Boucherie et al., 2011; Lund et al., 2006; Lu et al., 2009a; Meyer et al., 2011; Osakada et al., 2008; Idelson et al., 2009; Lamba et al., 2006, 2010; Carr et al., 2009; Ikeda et al., 2005; Kawasaki et al., 2002)....
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...Several recent advances in generating 3-dimensional (3D) organ-like tissues, called ‘organoids’, have been reported (Meyer et al., 2011; Spence et al., 2011; Nakano et al., 2012; Takebe et al., 2013; Lancaster et al., 2013; McCracken et al., 2014)....
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