Journal ArticleDOI
Optical activity of aromatic chromophores. I. O, m, and p-tyrosine.
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TLDR
It was concluded that the Kirkwood “coupled oscillator” mechanism is capable of explaining the observed optical activity of the aromatic chromophores of the molecules that were investigated.Abstract:
The optical activity and the conformational energy of the amino acids tyrosine, o-tyrosine, and m-tyrosine have been calculated as a function of molecular conformation. A new graphic technique, rotatory strength–conformational energy maps, was developed for the presentation of these calculations. Experimental circular dichroism spectra were determined by utilization of a new experimental technique that involves complete computer control of a Cary spectropolarimeter. This permitted repetitive scanning with signal averaging over extended time periods and resulted in a greatly enhanced signal to noise ratio. On the basis of these calculations, it, was concluded that the Kirkwood “coupled oscillator” mechanism is capable of explaining the observed optical activity of the aromatic chromophores of the molecules that were investigated.read more
Citations
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Journal ArticleDOI
Aromatic contributions to circular dichroism spectra of proteins.
TL;DR: Aromatic Contributions To Circular Dichroism Spectra Of Protein this paper were discussed in detail in the CRC Critical Reviews in Biochemistry: Vol. 2, No. 1, pp. 113-175.
Book ChapterDOI
Circular dichroism and optical rotatory dispersion of proteins and polypeptides.
TL;DR: This chapter discusses the methodology of circular dichroism (CD) and optical rotatory dispersion (ORD) data gathering and analysis in the rapidly changing field of protein structure, making use of synthetic polypeptide studies when necessary.
Journal ArticleDOI
Aromatic side-chain contribution to far-ultraviolet circular dichroism of helical peptides and its effect on measurement of helix propensities.
TL;DR: Amide proton exchange measurements by proton nuclear magnetic resonance spectroscopy indicate that the Tyr, Trp, and Ala peptides possess similar amounts of H-bonded secondary structure.
Journal ArticleDOI
Conformational states and biological activity of cyclic peptides
Book ChapterDOI
12 Pancreatic Ribonuclease
Peter Blackburn,Stanford Moore +1 more
TL;DR: The usefulness of the cytoplasmic inhibitor of RNase to protect RNA in the course of the synthesis of complementary DNA by reverse transcriptase is discussed.
References
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Journal ArticleDOI
Classification of Spectra of Cata-Condensed Hydrocarbons
TL;DR: In this paper, the classification of π-orbitals in a cata-condensed aromatic system is like that of the orbitals of a free electron traveling in a one-dimensional loop of constant potential around the perimeter.
Journal ArticleDOI
Electronic Structure and Spectra of Nitrogen Heterocycles
Noboru Mataga,Kitisuke Nishimoto +1 more
Journal ArticleDOI
Electronic Structure and Spectra of Some Nitrogen Heterocycles
Kitisuke Nishimoto,Noboru Mataga +1 more
Journal ArticleDOI
Optical Rotatory Dispersion of Helical Polymers
TL;DR: In this paper, it was shown that for every transition in its individual residues, a helix has two transitions whose moments are respectively parallel and perpendicular to the screw axis, and that the largest contributions to the rotational strengths of these bands are equal and opposite in the two cases.