Optical Coherence Tomography
01 Dec 2013-pp 135-170
About: The article was published on 2013-12-01. It has received 235 citations till now. The article focuses on the topics: Optical coherence tomography.
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TL;DR: An international panel with expertise in retinal imaging was assembled and a nomenclature system for normal anatomic landmarks seen on SD-OCT outputs has been proposed and adopted and recommended for use in future publications.
708 citations
TL;DR: Optical coherence tomography angiography provides depth-resolved information and detailed images of CNV in neovascular AMD and provides more distinct vascular network patterns that were less obscured by subretinal hemorrhage.
636 citations
TL;DR: High-resolution Fourier-domain OCT mapped corneal epithelial thickness with good repeatability in both normal and keratoconic eyes and found that keratoconus was characterized by apical epithelial thinning.
286 citations
TL;DR: In this article, a full-range complex spectral domain optical coherence tomography with an ultra-broadband light source based on sinusoidal modulation is presented, where a lead zirconate titanate stack actuator is employed to achieve the sinusoid vibration of a mirror and therefore to get a series of spectral interferogram with different phase delays.
Abstract: We present a full-range complex spectral domain optical coherence tomography with an ultra-broadband light source based on sinusoidal modulation. For the sinusoidal modulation strategy, a lead zirconate titanate stack actuator is employed to achieve the sinusoidal vibration of a mirror and therefore to get a series of spectral interferogram with different phase delays. The purpose of this strategy is to get higher performance complex-conjugate artifact elimination. Bessel separation of the signal sequence at each wavelength of the spectrometer was used to reconstruct the real and imaginary components of interference fringes; however, the sinusoidal modulation method is independent of light source wavelength. The experimental results demonstrated that the method had an excellent performance in a complex-conjugate suppression of 50 dB for a full width at half maximum bandwidth of 236 nm, and it has better anti-artifact ability and more flexible range in phase shifting than the conventional wavelength-dependent phase-shifting method on a full-range complex spectral optical coherence tomography system. Furthermore, the effect of the hysteresis error of lead zirconate titanate actuators on the performance of complex-conjugate artifact elimination was investigated and the solution of lead zirconate titanate positioning performance for both conventional phase-shifting and sine-modulation methods was suggested.
260 citations
TL;DR: The current understanding of OCT image interpretation in patients with AMD is summarized by summarizing the current understanding and how OCT can best be applied in clinical practice are described.
241 citations
References
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TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Abstract: A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.
11,568 citations
2,834 citations
TL;DR: Results are presented which demonstrate the superior sensitivity of swept source (SS) and Fourier domain (FD) optical coherence tomography (OCT) techniques over the conventional time domain (TD) approach.
Abstract: We present theoretical and experimental results which demonstrate the superior sensitivity of swept source (SS) and Fourier domain (FD) optical coherence tomography (OCT) techniques over the conventional time domain (TD) approach. We show that SS- and FD-OCT have equivalent expressions for system signal-to-noise ratio which result in a typical sensitivity advantage of 20-30dB over TD-OCT. Experimental verification is provided using two novel spectral discrimination (SD) OCT systems: a differential fiber-based 800nm FD-OCT system which employs deep-well photodiode arrays, and a differential 1300nm SS-OCT system based on a swept laser with an 87nm tuning range.
2,109 citations
TL;DR: It is shown that FDOCT systems have a large sensitivity advantage and allow for sensitivities well above 80dB, even in situations with low light levels and high speed detection.
Abstract: In this article we present a detailed discussion of noise sources in Fourier Domain Optical Coherence Tomography (FDOCT) setups. The performance of FDOCT with charge coupled device (CCD) cameras is compared to current standard time domain OCT systems. We describe how to measure sensitivity in the case of FDOCT and confirm the theoretically obtained values. It is shown that FDOCT systems have a large sensitivity advantage and allow for sensitivities well above 80dB, even in situations with low light levels and high speed detection.
2,104 citations
TL;DR: The guidelines for the diagnosis, surveillance and therapy of Barrett’s esophagus were originally published by the American College of Gastroenterology in 1998 and updated in 2002 and once again reviewed using the National Library of Medicine database.
2,044 citations