Journal ArticleDOI
Optimization of the dose and route of injection, and characterisation of the time course of carbon tetrachloride-induced hepatotoxicity in the rat.
Sana Janakat,Hela Al-Merie +1 more
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TLDR
The optimum intraperitoneal dose of CCl(4) was found to be 2 ml/kg body weight (dissolved in an equal volume of olive oil), and this increased the level of bilirubin and the activity of the three enzymes significantly, without causing death of the animals.About:
This article is published in Journal of Pharmacological and Toxicological Methods.The article was published on 2002-07-01. It has received 59 citations till now. The article focuses on the topics: Intraperitoneal injection & Carbon tetrachloride.read more
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Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis.
M. T. Abdel Aziz,Hazem Atta,Soheir Mahfouz,Hanan Fouad,Nagwa K. Roshdy,Hanaa H. Ahmed,Laila A. Rashed,Dina Sabry,Amira Hassouna,N.M. Hasan +9 more
TL;DR: Results of the present study showed that MSC have a potential therapeutic effect against the fibrotic process through their effect in minimizing collagen deposition in addition to their capacity to differentiate into hepatocytes.
Journal ArticleDOI
Protective effects of Digera muricata (L.) Mart. on testis against oxidative stress of carbon tetrachloride in rat.
TL;DR: Results clearly demonstrate that D. muricata treatment augments the antioxidants defense mechanism against carbon tetrachloride induced toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases.
Journal ArticleDOI
Protective effects of Pycnogenol® on carbon tetrachloride-induced hepatotoxicity in Sprague–Dawley rats
Young-Su Yang,Tai-Hwan Ahn,Jong-Chan Lee,Changjong Moon,Sung-Ho Kim,Woojin Jun,Seung-Chun Park,Hyoung-Chin Kim,Jong-Choon Kim +8 more
TL;DR: Results indicate that PYC has a protective effect against acute hepatotoxicity induced by the administration of CCl4 in rats, and that the hepatoprotective effects of PYC may be due to both the inhibition of lipid peroxidation and the increase of antioxidant activity.
Journal ArticleDOI
Mesenchymal stem cell infusion therapy in a carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression
Vahideh Rabani,Mansoureh Shahsavani,Marzieh Gharavi,Abbas Piryaei,Abbas Piryaei,Zahra Azhdari,Hossein Baharvand,Hossein Baharvand +7 more
TL;DR: MSCs can enhance recovery of a CCl4‐injured mouse liver through their influence in reducing collagen deposition by possibly affecting expression of MMPs.
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Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation
TL;DR: The present study is the first description of a cirrhotic model in mice developed by subcutaneous injections of CCl4, and will facilitate use of knock‐out or transgenic mice and lead to a better understanding of the underlying molecular pathways in the field of portal hypertension and cirrhosis.
References
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Methods of Enzymatic Analysis
TL;DR: Methods of enzymatic analysis, Methods of enzymes analysis, the authors, Methods of enzyme analysis, enzymatics, methods of enzymes, and methods of analysis, method of enzymes.
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A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
Stanley Reitman,Sam Frankel +1 more
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Hepatoprotective activity of carrot (daucus carota l.) against carbon tetrachloride intoxication in mouse liver
TL;DR: The effect of carrot extract on carbon tetrachloride (CCl4)-induced acute liver damage was evaluated in this paper, which revealed that carrot could afford a significant protective action in the alleviation of CCl4-induced hepatocellular injury.
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Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa.
Chhaya Gadgoli,Shri Hari Mishra +1 more
TL;DR: P-Methoxy benzoic acid isolated from the methanolic soluble fraction of the aqueous extract of Capparis spinosa L. (Capparidaceae) was found to possess significant antihepatotoxic activity against carbontetrachloride and paracetamol induced hepatotoxicity in vivo and thioacetamide and galactosamine induced hepatOToxicity in isolated rat hepatocytes, using in vitro technique.