Oral Immunotherapy for Treatment of Egg Allergy in Children
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TLDR
To determine that oral immunotherapy (OIT) to egg is safe and effective to desensitize patients and induce sustained unresponsiveness, a double-blind, randomized placebo-controlled study of 55 children, sensitive to egg, is conducted.Abstract:
AW Burks, SM Jones, RA Wood; Consortium of Food Allergy Research (CoFAR) N Engl J Med 2012;367(3):233–243
To determine that oral immunotherapy (OIT) to egg is safe and effective to desensitize patients and induce sustained unresponsiveness
A double-blind, randomized placebo-controlled study of 55 children, 5 to 11 years of age, sensitive to egg, with 40 receiving OIT and 15 placebo
Initial dose escalation and buildup, maintenance phases up to 2 g of egg protein (one-third egg) This was followed by an oral …read more
Citations
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Journal ArticleDOI
Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy
Graham Roberts,Peter H. Sayre,Henry T. Bahnson,Suzana Radulovic,Alexandra F. Santos,Helen A. Brough,Deborah Phippard,Monica Basting,Mary Feeney,Victor Turcanu,Michelle L. Sever,Margarita Gomez Lorenzo,Marshall Plaut +12 more
TL;DR: The early introduction of peanuts significantly decreased the frequency of the development of peanut allergy among children at high risk for this allergy and modulated immune responses to peanuts.
Journal ArticleDOI
AR101 Oral Immunotherapy for Peanut Allergy
Brian P. Vickery,Andrea Vereda,Thomas B. Casale,Kirsten Beyer,George Du Toit,Jonathan O'b Hourihane,Stacie M. Jones,Stacie M. Jones,Wayne G. Shreffler,Annette Marcantonio,Rezi Zawadzki,Lawrence Sher,W. Carr,Stanley Fineman,Leon Greos,Rima Rachid,M Dolores Ibáñez,Stephen A. Tilles,Amal Assa'ad,Caroline Nilsson,Ned Rupp,Michael J Welch,Gordon Sussman,Sharon Chinthrajah,Katharina Blumchen,Ellen Sher,Jonathan M. Spergel,Frederick E Leickly,Stefan Zielen,Julie Wang,Georgiana M Sanders,Robert A. Wood,Amarjit Cheema,Carsten Bindslev-Jensen,Stephanie A. Leonard,Rita Kachru,Douglas T Johnston,Frank C Hampel,Edwin H. Kim,Aikaterini Anagnostou,Jacqueline A. Pongracic,Moshe Ben-Shoshan,Hemant P Sharma,Allan Stillerman,Hugh H Windom,William H. Yang,Antonella Muraro,José Manuel Zubeldia,Vibha Sharma,Morna J. Dorsey,Hey Chong,Jason A. Ohayon,J. Andrew Bird,Tara F. Carr,Dareen Siri,Montserrat Fernandez-Rivas,David K Jeong,David Fleischer,Jay A. Lieberman,Anthony E.J. Dubois,Marina Tsoumani,Christina E. Ciaccio,Jay M. Portnoy,Lyndon E Mansfield,Stephen B Fritz,Bruce J. Lanser,Jonathan Matz,Hanneke N G Oude Elberink,Pooja Varshney,Stephen G Dilly,Daniel C. Adelman,A. Wesley Burks +71 more
TL;DR: Treatment with AR101 resulted in higher doses of peanut protein that could be ingested without dose‐limiting symptoms and in lower symptom severity during peanut exposure at the exit food challenge than placebo, in this phase 3 trial of oral immunotherapy in children and adolescents who were highly allergic to peanut.
Journal ArticleDOI
Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report.
A.W. Burks,Moises A. Calderon,Thomas B. Casale,Linda Cox,Pascal Demoly,Marek Jutel,Harold S. Nelson,Cezmi A. Akdis +7 more
TL;DR: An expert team was nominated to develop a comprehensive consensus report on the mechanisms of AIT and its use in clinical practice, as well as unmet needs and ongoing developments in AIT.
Journal ArticleDOI
International consensus on allergy immunotherapy
Marek Jutel,Ioana Agache,Sergio Bonini,A. Wesley Burks,Moises A. Calderon,Walter Canonica,Linda Cox,Pascal Demoly,A. J. Frew,Robin O'Hehir,Jörg Kleine-Tebbe,Antonella Muraro,Gideon Lack,Désirée Larenas,Michael Levin,Harald Nelson,Ruby Pawankar,Oliver Pfaar,Ronald van Ree,Hugh A. Sampson,Alexandra F. Santos,George Du Toit,Thomas Werfel,Roy Gerth van Wijk,Luo Zhang,Cezmi A. Akdis +25 more
TL;DR: The international community of allergy specialists recognizes the need to develop a comprehensive consensus report to harmonize, disseminate, and implement the best AIT practice.
Journal ArticleDOI
Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)
Aleena Syed,Marco Garcia,Shu Chen Lyu,Robert Bucayu,Arunima Kohli,Satoru Ishida,Jelena P. Berglund,Mindy Tsai,Holden T. Maecker,Gerri O'Riordan,Stephen J. Galli,Kari C. Nadeau +11 more
TL;DR: Modifications at the DNA level of antigen-induced T-cell subsets might be predictive of a state of operationally defined clinical immune tolerance during peanut OIT.
References
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Journal ArticleDOI
Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy
Graham Roberts,Peter H. Sayre,Henry T. Bahnson,Suzana Radulovic,Alexandra F. Santos,Helen A. Brough,Deborah Phippard,Monica Basting,Mary Feeney,Victor Turcanu,Michelle L. Sever,Margarita Gomez Lorenzo,Marshall Plaut +12 more
TL;DR: The early introduction of peanuts significantly decreased the frequency of the development of peanut allergy among children at high risk for this allergy and modulated immune responses to peanuts.
Journal ArticleDOI
EAACI Molecular Allergology User's Guide.
Paolo Maria Matricardi,Jörg Kleine-Tebbe,Hans Jürgen Hoffmann,Rudolf Valenta,Christiane Hilger,Stephanie Hofmaier,Rob C. Aalberse,Ioana Agache,Riccardo Asero,Barbara Ballmer-Weber,Domingo Barber,Kirsten Beyer,Tilo Biedermann,M. B. Bilò,Simon Blank,Barbara Bohle,Philipp P. Bosshard,Heimo Breiteneder,Helen A. Brough,Luis Caraballo,J-C Caubet,Reto Crameri,Janet M. Davies,Nikolaos Douladiris,M. Ebisawa,Philippe Eigenmann,Montserrat Fernandez-Rivas,Fatima Ferreira,Gabriele Gadermaier,Martin Glatz,Robert G. Hamilton,Thomas Hawranek,P W Hellings,Karin Hoffmann-Sommergruber,Thilo Jakob,Uta Jappe,Marek Jutel,Sandip D. Kamath,Edward F. Knol,Peter Korošec,Annette Kuehn,Gideon Lack,Gideon Lack,Andreas L. Lopata,Mika J. Mäkelä,Martine Morisset,Verena Niederberger,Anna Nowak-Wegrzyn,Nikolaos G. Papadopoulos,Elide A. Pastorello,Gabrielle Pauli,Thomas A.E. Platts-Mills,Daniela Posa,Lars K. Poulsen,Monika Raulf,Joaquín Sastre,Enrico Scala,Johannes Schmid,Peter Schmid-Grendelmeier,M. van Hage,R. van Ree,Stefan Vieths,Richard W. Weber,Magnus Wickman,Antonella Muraro,Markus Ollert +65 more
TL;DR: The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) as mentioned in this paper provides comprehensive information on important allergens and describes the diagnostic options using component-resolved diagnosis (CRD).
Journal ArticleDOI
AR101 Oral Immunotherapy for Peanut Allergy
Brian P. Vickery,Andrea Vereda,Thomas B. Casale,Kirsten Beyer,George Du Toit,Jonathan O'b Hourihane,Stacie M. Jones,Stacie M. Jones,Wayne G. Shreffler,Annette Marcantonio,Rezi Zawadzki,Lawrence Sher,W. Carr,Stanley Fineman,Leon Greos,Rima Rachid,M Dolores Ibáñez,Stephen A. Tilles,Amal Assa'ad,Caroline Nilsson,Ned Rupp,Michael J Welch,Gordon Sussman,Sharon Chinthrajah,Katharina Blumchen,Ellen Sher,Jonathan M. Spergel,Frederick E Leickly,Stefan Zielen,Julie Wang,Georgiana M Sanders,Robert A. Wood,Amarjit Cheema,Carsten Bindslev-Jensen,Stephanie A. Leonard,Rita Kachru,Douglas T Johnston,Frank C Hampel,Edwin H. Kim,Aikaterini Anagnostou,Jacqueline A. Pongracic,Moshe Ben-Shoshan,Hemant P Sharma,Allan Stillerman,Hugh H Windom,William H. Yang,Antonella Muraro,José Manuel Zubeldia,Vibha Sharma,Morna J. Dorsey,Hey Chong,Jason A. Ohayon,J. Andrew Bird,Tara F. Carr,Dareen Siri,Montserrat Fernandez-Rivas,David K Jeong,David Fleischer,Jay A. Lieberman,Anthony E.J. Dubois,Marina Tsoumani,Christina E. Ciaccio,Jay M. Portnoy,Lyndon E Mansfield,Stephen B Fritz,Bruce J. Lanser,Jonathan Matz,Hanneke N G Oude Elberink,Pooja Varshney,Stephen G Dilly,Daniel C. Adelman,A. Wesley Burks +71 more
TL;DR: Treatment with AR101 resulted in higher doses of peanut protein that could be ingested without dose‐limiting symptoms and in lower symptom severity during peanut exposure at the exit food challenge than placebo, in this phase 3 trial of oral immunotherapy in children and adolescents who were highly allergic to peanut.
Journal ArticleDOI
Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report.
A.W. Burks,Moises A. Calderon,Thomas B. Casale,Linda Cox,Pascal Demoly,Marek Jutel,Harold S. Nelson,Cezmi A. Akdis +7 more
TL;DR: An expert team was nominated to develop a comprehensive consensus report on the mechanisms of AIT and its use in clinical practice, as well as unmet needs and ongoing developments in AIT.
Journal ArticleDOI
International consensus on allergy immunotherapy
Marek Jutel,Ioana Agache,Sergio Bonini,A. Wesley Burks,Moises A. Calderon,Walter Canonica,Linda Cox,Pascal Demoly,A. J. Frew,Robin O'Hehir,Jörg Kleine-Tebbe,Antonella Muraro,Gideon Lack,Désirée Larenas,Michael Levin,Harald Nelson,Ruby Pawankar,Oliver Pfaar,Ronald van Ree,Hugh A. Sampson,Alexandra F. Santos,George Du Toit,Thomas Werfel,Roy Gerth van Wijk,Luo Zhang,Cezmi A. Akdis +25 more
TL;DR: The international community of allergy specialists recognizes the need to develop a comprehensive consensus report to harmonize, disseminate, and implement the best AIT practice.