Oral status in patients with early rheumatoid arthritis: a prospective, case–control study
Björn Wolff,Timo Berger,Cornelia Frese,Regina Max,Norbert Blank,Hanns-Martin Lorenz,Diana Wolff +6 more
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Increased loss of periodontal attachment and alveolar bone can be detected in patients with ERA, therefore it is proposed that the consulting rheumatologists inform the patients that they have a higher risk ofperiodontal disease.Abstract:
Objective. Patients with RA suffer from a higher risk of periodontal attachment loss and increased oral inflammation. We hypothesize that there are pathogenetic and immunological interactions between these diseases that go beyond impaired manual dexterity accompanying advanced RA. The primary objective of the present study was to determine whether a loss of alveolar bone can be detected in RA patients during the early course of the disease. Methods. In this cross-sectional, epidemiological casecontrol study, 22 patients with early RA (ERA) were compared with 22 matched healthy controls. Oral and periodontal status, clinical activity, and sociodemographic parameters were determined. Oral microbiota were analysed using real-time quantitative PCR specific for leading oral pathogens. Results. More advanced forms of periodontitis were found in ERA patients compared with controls. ERA patients had a greater number of missing teeth [ERA 5.7 (S.D. 5.0), controls 1.9 (S.D. 1.0), P = 0.002], deeper periodontal pockets [clinical attachment level: ERA 3.4 (S.D. 0.5 mm), controls 2.7 (S.D. 0.3 mm), P < 0.000], and greater bleeding on probing [ERA 18.6% (S.D. 9.0%), controls 10.5% (S.D. 5.1%), P = 0.001] despite comparable oral hygiene. Tannerella forsythia (6.77-fold, P = 0.033) subgingivally and Streptococcus anginosus (3.56-fold, P = 0.028) supragingivally were the characteristic pathogens in ERA. Conclusion. Increased loss of periodontal attachment and alveolar bone can be detected in patients with ERA, therefore we propose that the consulting rheumatologists inform the patients that they have a higher risk of periodontal disease. It would be beneficial if these patients were referred directly for intensive dental care.read more
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Does the microbiota play a role in the pathogenesis of autoimmune diseases
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Hand to Mouth: A Systematic Review and Meta-Analysis of the Association between Rheumatoid Arthritis and Periodontitis.
TL;DR: A significant association between RA and periodontitis is supported by the results of the systematic review and meta-analysis of studies comparing RA to healthy controls and this is not replicated when comparingRA to OA controls.
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Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases.
Bei-di Chen,Luxi Sun,Xuan Zhang +2 more
TL;DR: Dysbiosis was detected in the gut and oral microbiomes of RA patients, but it was partially restored after treatment, and functional changes of microbiota and molecular mimicry of human antigens in RA individuals were found.
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Relationship between Periodontitis and Rheumatoid Arthritis: Review of the Literature.
TL;DR: The majority of the articles have confirmed that there is a correlation between PD and RA, since both disorders have characteristics in common and result from an imbalance in the immunoinflammatory response.
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How the microbiota shapes rheumatic diseases.
Tom Van de Wiele,Jens Van Praet,Jens Van Praet,Massimo Marzorati,Michael B. Drennan,Michael B. Drennan,Dirk Elewaut,Dirk Elewaut +7 more
TL;DR: The role of the gut microbiota in shaping local and systemic immune responses and how disturbances in the host–microorganism interplay can potentially affect the development and progression of rheumatic diseases are reviewed.
References
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Journal ArticleDOI
Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis
Jose U. Scher,Carles Ubeda,Michele Equinda,Raya Khanin,Yvonne A. P. Buischi,Agnes Viale,Lauren Lipuma,Mukundan Attur,Michael H. Pillinger,Gerald Weissmann,Dan R. Littman,Eric G. Pamer,Walter A. Bretz,Steven B. Abramson +13 more
TL;DR: The subgingival microbiota profile in Patients with new-onset RA was similar to that in patients with chronic RA and healthy subjects whose PD was of comparable severity, and overall exposure to P gingivalis was similar among the groups.
Journal Article
Association of Periodontal Disease and Tooth Loss with Rheumatoid Arthritis in the US Population
TL;DR: RA may be associated with tooth loss and periodontitis and in participants with seropositive RA there was a stronger association with dental health status, in particular with edentulism.
Journal ArticleDOI
Association Among Rheumatoid Arthritis, Oral Hygiene, and Periodontitis
Nicole Pischon,Tobias Pischon,J. Kröger,E. Gülmez,Bernd-Michael Kleber,Jean-Pierre Bernimoulin,Helga Landau,P.-G. Brinkmann,P. Schlattmann,Jan Zernicke,Frank Buttgereit,Jacqueline Detert +11 more
TL;DR: Only RA status and age remained significant predictors of periodontal disease in a stepwise logistic regression, including RA status, age, gender, education, smoking, alcohol consumption, and BMI.
Journal ArticleDOI
Quantitative Microbiological Study of Human Carious Dentine by Culture and Real-Time PCR: Association of Anaerobes with Histopathological Changes in Chronic Pulpitis
TL;DR: The data suggest that the presence of high levels of these bacteria in carious lesions may be indicative of irreversible pulpal pathology, and these anaerobes have been strongly implicated in endodontic infections that occur as sequelae to carious pulpitis.
Journal ArticleDOI
The association between rheumatoid arthritis and periodontal disease
TL;DR: There are findings that support the hypothesis that oral infections play a role in RA pathogenesis and the association of PD in RA patients with seropositivity toward rheumatoid factor and the anti-cyclic citrullinated peptide antibody is discussed.
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