Oral status in patients with early rheumatoid arthritis: a prospective, case–control study
Björn Wolff,Timo Berger,Cornelia Frese,Regina Max,Norbert Blank,Hanns-Martin Lorenz,Diana Wolff +6 more
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Increased loss of periodontal attachment and alveolar bone can be detected in patients with ERA, therefore it is proposed that the consulting rheumatologists inform the patients that they have a higher risk ofperiodontal disease.Abstract:
Objective. Patients with RA suffer from a higher risk of periodontal attachment loss and increased oral inflammation. We hypothesize that there are pathogenetic and immunological interactions between these diseases that go beyond impaired manual dexterity accompanying advanced RA. The primary objective of the present study was to determine whether a loss of alveolar bone can be detected in RA patients during the early course of the disease. Methods. In this cross-sectional, epidemiological casecontrol study, 22 patients with early RA (ERA) were compared with 22 matched healthy controls. Oral and periodontal status, clinical activity, and sociodemographic parameters were determined. Oral microbiota were analysed using real-time quantitative PCR specific for leading oral pathogens. Results. More advanced forms of periodontitis were found in ERA patients compared with controls. ERA patients had a greater number of missing teeth [ERA 5.7 (S.D. 5.0), controls 1.9 (S.D. 1.0), P = 0.002], deeper periodontal pockets [clinical attachment level: ERA 3.4 (S.D. 0.5 mm), controls 2.7 (S.D. 0.3 mm), P < 0.000], and greater bleeding on probing [ERA 18.6% (S.D. 9.0%), controls 10.5% (S.D. 5.1%), P = 0.001] despite comparable oral hygiene. Tannerella forsythia (6.77-fold, P = 0.033) subgingivally and Streptococcus anginosus (3.56-fold, P = 0.028) supragingivally were the characteristic pathogens in ERA. Conclusion. Increased loss of periodontal attachment and alveolar bone can be detected in patients with ERA, therefore we propose that the consulting rheumatologists inform the patients that they have a higher risk of periodontal disease. It would be beneficial if these patients were referred directly for intensive dental care.read more
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Does the microbiota play a role in the pathogenesis of autoimmune diseases
TL;DR: This review summarises the current status on the role of the microbiota in autoimmune diseases and offers novel insight into factors that initiate and drive disease progression, stratify patient risk for complications and ultimately deliver new therapeutic strategies.
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Hand to Mouth: A Systematic Review and Meta-Analysis of the Association between Rheumatoid Arthritis and Periodontitis.
TL;DR: A significant association between RA and periodontitis is supported by the results of the systematic review and meta-analysis of studies comparing RA to healthy controls and this is not replicated when comparingRA to OA controls.
Journal ArticleDOI
Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases.
Bei-di Chen,Luxi Sun,Xuan Zhang +2 more
TL;DR: Dysbiosis was detected in the gut and oral microbiomes of RA patients, but it was partially restored after treatment, and functional changes of microbiota and molecular mimicry of human antigens in RA individuals were found.
Journal ArticleDOI
Relationship between Periodontitis and Rheumatoid Arthritis: Review of the Literature.
TL;DR: The majority of the articles have confirmed that there is a correlation between PD and RA, since both disorders have characteristics in common and result from an imbalance in the immunoinflammatory response.
Journal ArticleDOI
How the microbiota shapes rheumatic diseases.
Tom Van de Wiele,Jens Van Praet,Jens Van Praet,Massimo Marzorati,Michael B. Drennan,Michael B. Drennan,Dirk Elewaut,Dirk Elewaut +7 more
TL;DR: The role of the gut microbiota in shaping local and systemic immune responses and how disturbances in the host–microorganism interplay can potentially affect the development and progression of rheumatic diseases are reviewed.
References
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Anti–TNF-α Immunotherapy Is Associated With Increased Gingival Inflammation Without Clinical Attachment Loss in Subjects With Rheumatoid Arthritis
TL;DR: Infliximab tended to aggravateGingival inflammation as indicated by differences in the modified gingival and papillary bleeding indices between subjects in groups I and II with coexisting periodontitis before and after treatment.
Journal ArticleDOI
Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real‐time PCR
TL;DR: Obligate anaerobes, including T. forthysia, P. gingivalis and E. saphenum, were identified predominantly in microflora from subjects with periodontitis, whereas Streptococcus species were identified mainly in micro Flora from periodontally healthy subjects, suggesting a change in the subgingival environment that resulted in conditions more suitable for the survival of obligate an aerobes.
Journal ArticleDOI
Association between chronic periodontitis and rheumatoid arthritis: a hospital-based case-control study.
TL;DR: The occurrence and severity of periodontitis was found to be higher in RA subjects as compared to subjects without RA, suggesting a positive relation between these two chronic inflammatory diseases.
Journal ArticleDOI
Periodontal disease is significantly higher in non-smoking treatment-naive rheumatoid arthritis patients: results from a case-control study
Damodaram Potikuri,Kalyan Chakravarthy Dannana,Suresh Kanchinadam,S Agrawal,Anuradha Kancharla,Liza Rajasekhar,Shantakumari Pothuraju,Narsimulu Gumdal +7 more
TL;DR: PD is more frequent and severe in non-smoking DMARD-naive RA patients compared with healthy controls and PD in RA is associated with high titres of ACPAs.
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