Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
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...Moreover, in eukaryotic cells, adenylate cyclases have been shown to function in cAMP microdomain...
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...Lipid rafts are areas of plasma membrane heterogeneity, characterized by high concentrations of cholesterol and sphingolipids, which are distinct from the glycerophospholipid-rich (nonraft) plasma membrane domains (350)....
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...Since the identification of the Ca(2) -stimulated PDE1 in 1970 (77, 201), 10 further members of this superfamily have been cloned and characterized (27, 88, 97, 113, 133, 149, 187, 240, 251, 427)....
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...It is important to acknowledge that both of these preparations at best may be frozen snapshots in the lives of what are dynamic assemblies (217, 241) or at worst, preparation-induced assemblies (16, 269)....
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...The notion that signaling elements can be concentrated in such domains and so rendered more efficient in their interaction has been enthusiastically embraced in many areas of signaling (302), but it would be reasonable to acknowledge that there is far from a universal consensus on what may be occurring (16, 269)....
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