Organization and segregation of bacterial chromosomes
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TLDR
It is argued that the key feature of compaction is the orderly folding of DNA along adjacent segments and that this organization provides easy and efficient access for protein–DNA transactions and has a central role in driving segregation.Abstract:
The bacterial chromosome must be compacted more than 1,000-fold to fit into the compartment in which it resides. How it is condensed, organized and ultimately segregated has been a puzzle for over half a century. Recent advances in live-cell imaging and genome-scale analyses have led to new insights into these problems. We argue that the key feature of compaction is the orderly folding of DNA along adjacent segments and that this organization provides easy and efficient access for protein-DNA transactions and has a central role in driving segregation. Similar principles and common proteins are used in eukaryotes to condense and to resolve sister chromatids at metaphase.read more
Citations
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How to get (a)round: mechanisms controlling growth and division of coccoid bacteria
TL;DR: Recent progress that has advanced knowledge of the complex mechanisms for chromosome segregation and cell division in bacteria which have, deceptively, the simplest possible shape: the cocci are discussed.
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Evidence for a DNA-relay mechanism in ParABS-mediated chromosome segregation
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References
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Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences*
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DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
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Cohesins: chromosomal proteins that prevent premature separation of sister chromatids
TL;DR: Three chromosmal proteins that prevent premature separation of sister chromatids in yeast are described, two of which are members of the SMC family, which are putative ATPases with coiled-coil domains.