Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro
TL;DR: In conclusion, orthosilicic acid at physiological concentrations stimulates collagen type 1 synthesis in human osteoblast-like cells and enhances osteoblastic differentiation.
About: This article is published in Bone.The article was published on 2003-02-01. It has received 773 citations till now. The article focuses on the topics: Osteoblast & Alkaline phosphatase.
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TL;DR: This review comprehensively covers literature reports which have investigated specifically the effect of dissolution products of silicate bioactive glasses and glass-ceramics in relation to osteogenesis and angiogenesis and focuses on the ion release kinetics of the materials and the specific effect of the released ionic dissolution products on human cell behaviour.
2,056 citations
Cites background from "Orthosilicic acid stimulates collag..."
...Moreover, orthosilicate acid (Si(OH)4) at physiological concentration of 10 mmol has been shown to stimulate collagen I formation in human osteoblast cells (HOC) and to stimulate osteoblastic differentiation [60]....
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...Si(OH)4 stimulates collagen I formation and osteoblastic differentiation [60]...
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TL;DR: The paper takes the reader from Hench's Bioglass 45S5 to new hybrid materials that have tailorable mechanical properties and degradation rates, covering the importance of control of hierarchical structure, synthesis, processing and cellular response in the quest for new regenerative synthetic bone grafts.
1,836 citations
Cites background from "Orthosilicic acid stimulates collag..."
...thought to be released from the glass in the form of silicic acid (Si(OH)4), which has been shown to stimulate collagen I production by human osteoblast cells at a concentration of 10 mmol [125]....
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TL;DR: It was found that hemolysis and the amount of adhered platelets decreased after alloying for all Mg-1X alloys as compared to the pure magnesium control.
1,174 citations
TL;DR: The currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect are reviewed.
1,109 citations
Cites background from "Orthosilicic acid stimulates collag..."
...dose-dependent enhancement of osteoblast proliferation, differentiation and collagen production were observed in vitro [281,343]....
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...4 ppm (50 mM Si) of orthosilicic acid [281]....
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TL;DR: The unique characteristics that make 2D nanoparticles so valuable are described, as well as the biocompatibility framework that has been investigated so far, to capture the growing trend of 2D nanomaterials for biomedical applications and to identify promising new research directions.
Abstract: Two-dimensional (2D) nanomaterials are ultrathin nanomaterials with a high degree of anisotropy and chemical functionality. Research on 2D nanomaterials is still in its infancy, with the majority of research focusing on elucidating unique material characteristics and few reports focusing on biomedical applications of 2D nanomaterials. Nevertheless, recent rapid advances in 2D nanomaterials have raised important and exciting questions about their interactions with biological moieties. 2D nanoparticles such as carbon-based 2D materials, silicate clays, transition metal dichalcogenides (TMDs), and transition metal oxides (TMOs) provide enhanced physical, chemical, and biological functionality owing to their uniform shapes, high surface-to-volume ratios, and surface charge. Here, we focus on state-of-the-art biomedical applications of 2D nanomaterials as well as recent developments that are shaping this emerging field. Specifically, we describe the unique characteristics that make 2D nanoparticles so valuable, as well as the biocompatibility framework that has been investigated so far. Finally, to both capture the growing trend of 2D nanomaterials for biomedical applications and to identify promising new research directions, we provide a critical evaluation of potential applications of recently developed 2D nanomaterials.
605 citations
References
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TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
225,085 citations
"Orthosilicic acid stimulates collag..." refers methods in this paper
...Protein concentrations were determined by the method of Bradford [25]....
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Book•
06 Jun 1979
TL;DR: Weber and van Olphen as discussed by the authors provide valuable guidance in research and design efforts by giving a clear understanding of principles and concepts of colloid chemistry as applied to clay systems, including surface characterization and adsorption mechanisms; recent results in the area of clay-organic interaction-the intercalation and intersalation of kaolinite minerals; and increased attention to the possible role of clays in biological evolution.
Abstract: Surfactants and Interfacial Phenomena Milton J. Rosen Bridging the gap between purely theoretical aspects of surface chemistry and the purely empirical experience of the industrial technologist, this book applies theoretical surface chemistry to understanding the action of surfactants in modifying interfacial phenomena. It surveys the structural types of commercially available surfactants and discusses interfacial phenomena, the physicochemical principles underlying the action of surfactants in each phenomenon, and the effect of structural changes in the surfactants and environmental changes on their action. Tables of data on various interfacial properties of surfactants, compiled and calculated from the latest scientific literature, are included. 1978 304 pp. An Introduction to Clay Colloid Chemistry, 2nd Ed. H. van Olphen This book provides valuable guidance in research and design efforts by giving a clear understanding of principles and concepts of colloid chemistry as applied to clay systems. Updated and enlarged, this edition includes new information on surface characterization and adsorption mechanisms; recent results in the area of clay-organic interaction-the intercalation and intersalation of kaolinite minerals; and increased attention to the possible role of clays in biological evolution. 1977 318 pp. Physicochemical Processes for Water Quality Control Walter J. Weber, Jr. Focusing on physicochemical rather than biological processes, this book presents a comprehensive treatise on the treatment of municipal and industrial water and wastewater. All of the physicochemical processes important to municipal and industrial water and wastewater treatment-coagulation, filtration, membrane processes, chemical oxidation, and others-are included and each is covered thoroughly from principle through application. To maintain a high level of expertise, contributions have been incorporated from specialists actively involved in research or engineering applications in ea
2,538 citations
01 Jan 1996
TL;DR: Basic principles - cell biology biochemistry bone re-modelling and mineral homeostasis the hormones of bone other systemic hormones that influence bone metabolism local regulators of bone molecular mechanisms of metabolic bone diseases pharmacological mechanisms of therapeutics methods in bone research.
Abstract: Basic principles - cell biology biochemistry bone re-modelling and mineral homeostasis the hormones of bone other systemic hormones that influence bone metabolism local regulators of bone molecular mechanisms of metabolic bone diseases pharmacological mechanisms of therapeutics methods in bone research.
1,650 citations
TL;DR: A set of polycationic peptides isolated from diatom cell walls were shown to generate networks of silica nanospheres within seconds when added to a solution of silicic acid.
Abstract: Diatom cell walls are regarded as a paradigm for controlled production of nanostructured silica, but the mechanisms allowing biosilicification to proceed at ambient temperature at high rates have remained enigmatic. A set of polycationic peptides (called silaffins) isolated from diatom cell walls were shown to generate networks of silica nanospheres within seconds when added to a solution of silicic acid. Silaffins contain covalently modified lysine-lysine elements. The first lysine bears a polyamine consisting of 6 to 11 repeats of the N-methyl-propylamine unit. The second lysine was identified as epsilon-N,N-dimethyl-lysine. These modifications drastically influence the silica-precipitating activity of silaffins.
1,306 citations
"Orthosilicic acid stimulates collag..." refers background in this paper
...Some plants and lower animals may promote this reaction, as they use polymeric silica for structure and growth [3,4,5]....
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