Journal ArticleDOI
Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms
Natalie A. Sims,T. John Martin +1 more
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TLDR
Evidence from osteopetrotic syndromes indicate that osteoclasts not only resorb bone, but also provide signals to promote bone formation, which mediate the coupling of bone formation to resorption in remodeling.Abstract:
Bone remodeling is essential for the repair and replacement of damaged and old bone. The major principle underlying this process is that osteoclast-mediated resorption of a quantum of bone is followed by osteoblast precursor recruitment; these cells differentiate to matrix-producing osteoblasts, which form new bone to replace what was resorbed. Evidence from osteopetrotic syndromes indicate that osteoclasts not only resorb bone, but also provide signals to promote bone formation. Osteoclasts act upon osteoblast lineage cells throughout their differentiation by facilitating growth factor release from resorbed matrix, producing secreted proteins and microvesicles, and expressing membrane-bound factors. These multiple mechanisms mediate the coupling of bone formation to resorption in remodeling. Additional interactions of osteoclasts with osteoblast lineage cells, including interactions with canopy and reversal cells, are required to achieve coordination between bone formation and resorption during bone remodeling.read more
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Osteoblast-Osteoclast Communication and Bone Homeostasis
TL;DR: The current knowledge regarding membrane bound- and soluble factors governing cross-talk between osteoblasts and osteoclasts is reviewed.
Journal ArticleDOI
Re-thinking the bone remodeling cycle mechanism and the origin of bone loss.
Jean-Marie Delaissé,Thomas Levin Andersen,Thomas Levin Andersen,Helene Bjoerg Kristensen,Pia Rosgaard Jensen,Christina Møller Andreasen,Kent Søe +6 more
TL;DR: The analysis of the resorption and cell population dynamics shows how teams of osteoclasts and osteoblast lineage cells are progressively established and how they are subjected therein to reciprocal interactions, and that osteoclast triggers putative osteoprogenitor reservoirs positioned at proximity of the eroded bone surface.
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Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: From Physiology to Medical Implications
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Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis
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Bone Regeneration, Reconstruction and Use of Osteogenic Cells; from Basic Knowledge, Animal Models to Clinical Trials.
Greg Hutchings,Lisa Moncrieff,Lisa Moncrieff,Claudia Dompe,Claudia Dompe,Krzysztof Janowicz,Krzysztof Janowicz,Rafał Sibiak,Artur Bryja,Maurycy Jankowski,Paul Mozdziak,Dorota Bukowska,Paweł Antosik,Jamil Awad Shibli,Marta Dyszkiewicz-Konwińska,Małgorzata Bruska,Bartosz Kempisty,Bartosz Kempisty,Hanna Piotrowska-Kempisty +18 more
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