Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value.
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...To help predict the occurrence and development of NSCLC, doctors use biomarkers in the clinic....
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...Abbreviations AFP: Alpha fetal protein; AFP-L3: Lens culinaris-agglutinin-reactive fraction of AFP; APL: Acute promyelocytic leukemia; CEA: Carcinoembryonic antigen; circRNAs: Circular RNAs; CIRI: CircRNA Identifier; ciRNAs: Circular intronic RNAs; CRC: Colorectal cancer; ecircRNA: Exonic circRNA; EIciRNA: Exon-intron circRNAs; ESCC: Esophageal squamous cell; GC: Gastric cancer; HCC: Hepatocellular carcinoma; Hif: Hypoxia-inducible factor; IRES: Internal ribosome entry site; LSCC: Laryngeal squamous cell cancer; NSCLC: Nonsmall-cell lung cancer; RCA: Rolling circle amplification; RNA-seq: RNA sequencing; snRNP: Small nuclear ribonucleo proteins Acknowledgements This work was supported by National Key Technology Research and Development program of the Ministry of Science and Technology of China(2014BAI04B02) (to M W)....
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...Lung cancer, which causes cancer-related deaths worldwide, comprises non-small-cell lung cancer (NSCLC) and small-cell lung cancer....
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...Cheng Wang et al. have demonstrated that miR-483-5p, miR-193a-3p, miR-25, miR-214 and miR-7 can potentially be used as biomarkers for diagnosing NSCLC patients [55]....
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...Coincidentally, up-regulated circRNA 100876 in NSCLC was found to closely correlate with lymph node metastasis (P = 0.001) and tumour staging (P = 0.001)....
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