Overview of SARS-CoV-2 infection in adults living with HIV.
Juan Ambrosioni,Jose-Luis Blanco,Juliana Reyes-Urueña,Mary-Ann Davies,Omar Sued,Maria Angeles Marcos,Esteban Martínez,Silvia Bertagnolio,Silvia Bertagnolio,José Alcamí,José Alcamí,José M. Miró,José Luis Santiago Blanco,Lorena de la Mora,Felipe Garcia-Alcaide,Ana González-Cordón,Alexis Inciarte,Montserrat Laguno,Lorna Leal,Esteban Martínez-Chamorro,María Martínez-Rebollar,Jhon Rojas,Berta Torres,Josep Mallolas,Laia Albiac,Daiana L. Agöero,Marta Bodro,Celia Cardozo,Mariana Chumbita,Nicol García,Carolina Garcia-Vidal,Marta Hernández-Meneses,Sabina Herrera,Laura Linares,Antonio Moreno,Laura Morata,Jose A. Martínez-Martínez,Pedro Puerta,Verónica Rico,Alex Soriano,M. Martinez,Maria Mar Mosquera,Maria Angeles Marcos,Jordi Vila,Montse Tuset,Dolors Soy,Anna Vilella,Alex Almuedo,María J. Pinazo,Jose Muñoz +49 more
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TLDR
A review of the most relevant features of COVID-19 in people living with HIV and highlighted topics where further research is required is provided in this article, where the authors have reviewed the most salient features of the COVID19 pandemic and highlighted the areas where further work is needed.About:
This article is published in The Lancet HIV.The article was published on 2021-05-01 and is currently open access. It has received 118 citations till now. The article focuses on the topics: Pandemic.read more
Citations
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Human genetic and immunological determinants of critical COVID-19 pneumonia
Qian Zhang,Paul Bastard,Adem Karbuz,A Gervais,Ahmad N. Abou Tayoun,Alessandro Aiuti,Alexandre Belot,Alexandre Bolze,Alexandre Gaudet,Anastasiia Bondarenko,Zhiyong Liu,András N Spaan,Andrea Guennoun,Andrés Augusto Arias,A. Planas,Anna Sediva,Anna Shcherbina,Anna-Lena Neehus,Anne Puel,Antoine Froidure,Antonio Novelli,Aslınur Özkaya Parlakay,Aurora Pujol,Aysun Yahşi,Belgin Gülhan,Benedetta Bigio,Bertrand Boisson,Beth A. Drolet,Carlos Andrés Arango Franco,Carlos Flores,Carlos Rodríguez-Gallego,Carolina Prando,Catherine M. Biggs,Charles-Edouard Luyt,Clifton L. Dalgard,Cliona O'Farrelly,Daniela Matuozzo,David Dalmau,David S. Perlin,Davood Mansouri,Diederik van de Beek,Donald C. Vinh,Elena Domínguez-Garrido,Elena W Y Hsieh,Emine Hafize Erdeniz,Emmanuelle Jouanguy,Esra Şevketoğlu,Estelle Talouarn,Eugenia Quiros-Roldan,Evangelos Andreakos,Eystein S. Husebye,Fahad Alsohime,Filomeen Haerynck,Giorgio Casari,G. Novelli,Gokhan Aytekın,Guillaume Morelle,Gülsüm Alkan,Gülsüm İclal Bayhan,Hagit Baris Feldman,Helen C. Su,Horst von Bernuth,Igor Resnick,Ingrid G Bustos,Isabelle Meyts,Isabelle Migeotte,Ivan Tancevski,Jacinta Bustamante,Jacques Fellay,Jamila El Baghdadi,Javier Martinez-Picado,Jérémie Rosain,Jeremy Manry,Jie Chen,John Christodoulou,J. B. Bohlen,José Luis Franco,Juan Li,Juan-Manuel Anaya,Julian Castaño Rojas,Junqiang Ye,K. M. Furkan Uddin,Kadriye Kart Yaşar,Kai Kisand,Keisuke Okamoto,Khalil Chaïbi,K. Mironska,László Maródi,Laurent Abel,Laurent Rénia,Lazaro Lorenzo,Lennart Hammarström,Lisa F. P. Ng,Lluis Quintana-Murci,Lucía Victoria Erazo,Luigi D. Notarangelo,Luis F. Reyes,Luis M. Allende,Luisa Imberti,Majistor Raj Luxman Maglorius Renkilaraj,Marcela Moncada-Vélez,Marie Materna,Mark E. Anderson,Marta Gut,Marwa Chbihi,Masato Ogishi,Melike Emiroglu,Mikko Seppänen,Mohammed Jasim Uddin,Mohammed Shahrooei,Natalie Carter Alexander,Nevin Hatipoğlu,Nico Marr,Nihal Akçay,Oksana Boyarchuk,Ondrej Slaby,O Akcan,Peng Zhang,Pere Soler-Palacín,Peter K. Gregersen,Petter Brodin,Pierre Garçon,Pierre-Emmanuel Morange,Qiang Pan-Hammarström,Qinhua Zhou,Quentin Philippot,Rabih Halwani,Rebeca Pérez de Diego,Romain Lévy,Rui-Fu Yang,Şadiye Kübra Tüter Öz,Saleh Al Muhsen,Saliha Kanık-Yüksek,Sara Elva Espinosa-Padilla,Sathishkumar Ramaswamy,Satoshi Okada,Sefika Elmas Bozdemir,Selma Erol Aytekin,Şemsi Nur Karabela,Sevgi Keles,Sevtap Şenoğlu,Shen-ying Zhang,Sotirija Duvlis,Stefan N. Constantinescu,Stéphanie Boisson-Dupuis,Stuart E. Turvey,Stuart G. Tangye,Takaki Asano,Tayfun Ozcelik,Tom Le Voyer,Tom Maniatis,Tomohiro Morio,Trine H. Mogensen,Vanessa Sancho-Shimizu,Vivien Béziat,Xavier Solanich,Yenan T. Bryceson,Y.L. Lau,Yuval Itan,Aurélie Cobat,Jean-Laurent Casanova +160 more
TL;DR: In this article , the molecular and cellular determinants of critical COVID-19 pneumonia were reviewed and the TLR3- and TLR7-dependent production of type I interferons by respiratory epithelial cells and plasmacytoid dendritic cells, respectively, is essential for host defence against SARS-CoV-2 infection.
Journal ArticleDOI
Associations between HIV infection and clinical spectrum of COVID-19: a population level analysis based on US National COVID Cohort Collaborative (N3C) data.
Xueying Yang,Jing Sun,Rena C Patel,Jiajia Zhang,Siyuan Guo,Qulu Zheng,Amy L. Olex,Bankole Olatosi,Sharon Weissman,Jessica Y Islam,Christopher G. Chute,Melissa Haendel,Gregory D. Kirk,Xiaoming Li,Richard A. Moffitt,Hana Akelsrod,Keith A. Crandall,Nora Francheschini,Evan French,Teresa Po-Yu Chiang,G Caleb-Alexander,Kathleen M Andersen,Amanda J. Vinson,Todd T. Brown,Roslyn B. Mannon +24 more
TL;DR: In this paper, the authors investigated whether people living with HIV are at elevated risk of adverse COVID-19 outcomes using the population-based National COVID Cohort Collaborative (N3C) data in the USA.
Posted ContentDOI
Persistent SARS-CoV-2 infection and intra-host evolution in association with advanced HIV infection
Farina Karim,Mohamed Ys Moosa,Bernadett I Gosnell,Cele Sandile,Jennifer Giandhari,Sureshnee Pillay,Houriiyah Tegally,Eduan Wilkinson,Emmanuel James San,Nokukhanya Msomi,Koleka Mlisana,Koleka Mlisana,Khadija Khan,Mallory Bernstein,Nithendra Manickchund Nithendra,Lavanya Singh,Upasana Ramphal,Willem A. Hanekom,Richard J Lessells,Richard J Lessells,Alex Sigal,Alex Sigal,Tulio de Oliveira,Tulio de Oliveira +23 more
TL;DR: In this article, a case of prolonged infection of SARS-CoV-2 in an individual with advanced HIV and antiretroviral treatment failure was presented, where the early emergence of the E484K substitution associated with escape from neutralizing antibodies, followed by other escape mutations and the N501Y substitution found in most variants of concern.
Journal ArticleDOI
Outcomes of patients with HIV and COVID-19 co-infection: a systematic review and meta-analysis
TL;DR: A systematic review and meta-analysis aimed to summarize the available information on the risk of hospitalization, severe disease, and death attributable to HIV in patients with COVID-19 as discussed by the authors .
Journal ArticleDOI
Sociodemographic, clinical, and immunological factors associated with SARS-CoV-2 diagnosis and severe COVID-19 outcomes in people living with HIV: a retrospective cohort study
Daniel Kwakye Nomah,Daniel Kwakye Nomah,Juliana Reyes-Urueña,Yesika Díaz,Sergio Moreno,Jordi Aceiton,Andreu Bruguera,Rosa Maria Vivanco-Hidalgo,Josep M. Llibre,Pere Domingo,Vicenç Falcó,Arkaitz Imaz,Cristina Cortés,Lluís Force,Emili Letang,Ingrid Vilaró,Jordi Casabona,José M. Miró,Esteve Muntada,Anna Esteve,Melchor Riera,Gemma Navarro,Hernando Knobel,Josep Mallolas,Daniel Podzamczer,Adrià Curran,Joaquín Burgos,Maria Gracia Mateo,Maria del Mar Gutierrez,Javier Murillas,Francisco Homar,Jose Vicente Fernández-Montero,Eva González,Joaquim Peraire,Francesc Vidal,Elena Leon,Àngels Masabeu,Amat-Joaquim Orti,David Dalmau,Angels Jaén,Elisabet Deig,Elisa de Lazzari,Leire Berrocal,Guillem Fernandez,Lucía Rodríguez,Freya Gargoulas,Toni Vanrell,Jose Carlos Rubia,Josep Vilà,Marina Martínez,Bibiana Morell,Maribel Tamayo,Jorge Palacio,Juan Ambrosioni,Montse Laguno,María Martínez-Rebollar,José Luis Santiago Blanco,Felipe García,Esteban Martínez,Berta Torres,Lorena de la Mora,Alexy Inciarte,Ainoa Ugarte,Iván Chivite,Ana González-Cordón,Lorna Leal,Antoni Jou,Maria Saumoy,Ana Silva,Sofia Scévola,Jordi Navarro,Paula Suanzes,Isabel Mur,Maria Angels Ribas,Antoni Campins,Francisco Fanjul,María Leyes,María Peñaranda,Maria Luisa Martin,Helem Haydee Vilchez,Sonia Calzado,Manel Cervantes,M. José Amengual,Marta Navarro,Antoni Payeras,Carmen Cifuentes,Aroa Villoslada,Patrícia Sorní,Marta Molero,Nadia Abdulghani,Thaïs Comella,Rocio Sola,Montserrat Vargas,Consuleo Viladés,Anna Martí,Pilar Barrufet,Laia Arbones,Elena Chamarro,Mireia Cairó,Xavier Martinez-Lacas,Roser Font,Lizza Macorigh +101 more
TL;DR: In this paper, the authors assessed the factors associated with SARS-CoV-2 diagnosis and severe outcomes among people living with HIV using univariable and multivariable Cox regression models.
References
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Yeming Wang,Yeming Wang,Dingyu Zhang,Guanhua Du,Ronghui Du,Jianping Zhao,Yang Jin,Shouzhi Fu,Ling Gao,Zhenshun Cheng,Qiaofa Lu,Yi Hu,Guangwei Luo,Ke Wang,Yang Lu,Huadong Li,Shuzhen Wang,Shunan Ruan,Chengqing Yang,Chunlin Mei,Yi Wang,Dan Ding,Feng Wu,Xin Tang,Xianzhi Ye,Yingchun Ye,Bing Liu,Jie Yang,Wen Yin,Aili Wang,Guohui Fan,Fei Zhou,Zhibo Liu,Xiaoying Gu,Jiuyang Xu,Lianhan Shang,Lianhan Shang,Yi Zhang,Lianjun Cao,Guo Tingting,Yan Wan,Hong Qin,Yushen Jiang,Thomas Jaki,Thomas Jaki,Frederick G. Hayden,Peter Horby,Bin Cao,Chen Wang +48 more
TL;DR: In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits, however, the numerical reduction in time to clinical improvement in those treated earlier requires confirmation in larger studies.
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