Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine.
Rasoul Mirzaei,Rokhsareh Mohammadzadeh,Farzad Mahdavi,Fariba Badrzadeh,Sheida Kazemi,Mehdi Ebrahimi,Fatemeh Soltani,Sima Kazemi,Ali Salimi Jeda,Mohammad Darvishmotevalli,Rasoul Yousefimashouf,Hossein Keyvani,Sajad Karampoor +12 more
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TLDR
Effective vaccines against COVID-19 are urgently required to overcome the tremendous burden of mortality and morbidity correlated with SARS-CoV-2.About:
This article is published in International Immunopharmacology.The article was published on 2020-08-24 and is currently open access. It has received 30 citations till now. The article focuses on the topics: Viral Vaccine & Coronavirus.read more
Citations
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COVID-19 vaccines: The status and perspectives in delivery points of view.
TL;DR: In this paper, the virology and immunology of SARS-CoV-2, alternative therapies for COVID-19 to vaccination, principles and design considerations in vaccine development, and the promises and roles of vaccine carriers in addressing the unique immunopathological challenges presented by the disease.
Journal ArticleDOI
COVID-19 Transmission, Current Treatment, and Future Therapeutic Strategies.
Vrishali S. Salian,Jessica A. Wright,Peter T. Vedell,Sanjana Nair,Chenxu Li,Mahathi Kandimalla,Xiaojia Tang,Eva M. Carmona Porquera,Krishna R. Kalari,Karunya K. Kandimalla +9 more
TL;DR: In this article, the authors provided an overview of COVID-19 etiology vis-a-vis other zoonotic diseases, particularly SARS and MERS, and summarized various approaches and technologies employed to develop vaccines against COVID19 and summarized the attempts to repurpose various classes of drugs and novel therapeutic approaches.
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Bidirectional Association Between COVID-19 and the Environment: a Systematic Review.
Nayereh Rezaie Rahimi,Reza Fouladi-Fard,Rahim Aali,Ali Shahryari,Mostafa Rezaali,Yadollah Ghafouri,Mohammad Rezvani Ghalhari,Mahdi Asadi-Ghalhari,Babak Farzinnia,Oliveri Conti Gea,Maria Fiore +10 more
TL;DR: A review of the literature on SARS-CoV-2 (COVID-19) and its impact on the environment is presented in this paper, where the authors highlight how the virus is impacted by the environment and how it has impacted the environment.
Journal ArticleDOI
The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Rasoul Mirzaei,Farzad Mahdavi,Fariba Badrzadeh,Seyed Reza Hosseini-Fard,Maryam Heidary,Ali Salimi Jeda,Tayeb Mohammadi,Mahdane Roshani,Rasoul Yousefimashouf,Hossein Keyvani,Mohammad Darvishmotevalli,Melika Zarei Sani,Sajad Karampoor +12 more
TL;DR: A general review of current studies concerning the function of miRNAs in different VRIs, particularly in coronavirus infection, and address all available therapeutic prospects to mitigate the burden of viral infections is presented.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.