Journal ArticleDOI
Oxidative stress and mitochondrial dysfunction in glaucoma.
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TLDR
This review will consider the evidence for the presence of oxidative stress in glaucoma; the mechanisms by which oxidative stress may contribute to disease pathogenesis; and also consider therapeutic approaches that target oxidative stress as a means of protecting against optic nerve degeneration.About:
This article is published in Current Opinion in Pharmacology.The article was published on 2013-02-01. It has received 295 citations till now. The article focuses on the topics: Oxidative stress & Mitochondrion.read more
Citations
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Journal ArticleDOI
Deciphering the Molecular Signals of PINK1/Parkin Mitophagy
TL;DR: The molecular signals of Pink1/Parkin mitophagy and the ubiquitin code that drives not only Parkin recruitment and activation by PINK1 but also the downstream signaling events ofMitophagy are discussed.
Journal ArticleDOI
Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice
Peter A. Williams,Jeffrey M. Harder,Nicole E. Foxworth,Kelly E. Cochran,Vivek M. Philip,Vittorio Porciatti,Oliver Smithies,Simon W. M. John,Simon W. M. John +8 more
TL;DR: Studying glaucoma-prone mice, it is shown that mitochondrial abnormalities are an early driver of neuronal dysfunction, occurring before detectable degeneration, and this supports therapeutic use of vitamin B3 in glau coma and potentially other age-related neurodegenerations.
Journal ArticleDOI
Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases
Nicolás Cuenca,Laura Fernández-Sánchez,Laura Campello,Victoria Maneu,Pedro de la Villa,Pedro Lax,Isabel Pinilla +6 more
TL;DR: An overview of the common and distinctive features of retinal neurodegenerative diseases, including the molecular, anatomical and functional changes caused by the cellular response to damage, are provided in order to establish appropriate treatments for these pathologies.
Journal ArticleDOI
The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma
Ana I. Ramírez,Rosa de Hoz,Elena Salobrar-García,Juan J. Salazar,Blanca Rojas,Daniel Ajoy,Inés López-Cuenca,Pilar Rojas,Pilar Rojas,Alberto Triviño,José Ramírez +10 more
TL;DR: The aim of the present review is to describe the contribution in retina to microglial-mediated neuroinflammation in AD, PD, and glaucomatous neurodegeneration.
Journal Article
Retinal Oxidative Stress Induced by High Intraocular Pressure
María Cecilia Moreno,Daniel A. Sáenz,Julieta Campanelli,M.I. Keller Sarmiento,Jorge Benozzi,R.E. Rosenstein +5 more
TL;DR: Manipulation of intracellular redox status using antioxidants may be a new therapeutic tool to prevent glaucomatous neurodegeneration in rats withGlaucoma induced by the chronic injection of hyaluronic acid in the eye anterior chamber.
References
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Journal ArticleDOI
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin,M. Flint Beal +1 more
TL;DR: Treatments targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise in ageing-related neurodegenerative diseases.
Journal ArticleDOI
Mitochondrial free radical generation, oxidative stress, and aging.
TL;DR: In this article, the authors reviewed the mitochondrial rates of production and steady state levels of reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes.
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Mitochondrial optic neuropathies – Disease mechanisms and therapeutic strategies
TL;DR: Optic nerve degeneration in LHON and DOA is therefore due to disturbed mitochondrial function and a predominantly complex I respiratory chain defect has been identified using both in vitro and in vivo biochemical assays.
Journal ArticleDOI
The role of oxidative stress in glaucoma.
TL;DR: The highlighting of the pathogenic role of ROS in POAG has implications for the prevention of this disease as indicated by the growing number of studies using genetic analyses to identify susceptible individuals and of clinical trials testing the efficacy of antioxidant drugs for POAG management.
Journal ArticleDOI
Oxidative stress in Alzheimer disease: a possibility for prevention.
David J. Bonda,Xinglong Wang,George Perry,George Perry,Akihiko Nunomura,Massimo Tabaton,Xiongwei Zhu,Mark A. Smith +7 more
TL;DR: This review elaborate on the dynamic role of oxidative stress in AD and present corresponding treatment strategies that are currently under investigation, and allude to the possibility of a preventative cure.
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