Oxidative stress in Alzheimer's disease
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Cites background from "Oxidative stress in Alzheimer's dis..."
...SOD, GPx, and GRd are three enzymes involved in cellular protection against damage induced by oxygen-derived free radicals [14]....
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...Oxidative stress can be due to either an increase in ROS production or a decrease in the activity of the antioxidant enzymes such as SOD and GPx or nonenzymatic antioxidants, namely, vitamin E or GSH [14]....
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...Manganese-SOD detoxifies superoxide anion (O2−) to give H2O2, which is then converted into H2O by either GPx or catalase [14]....
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...Aβ-mediated oxidative stress can be due to either an increase in reactive oxygen species (ROS) production or a decrease in the endogenous antioxidants, namely, in the activity of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) and of nonenzymatic antioxidants such as vitamin E and GSH [14]....
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...GSH is one of the most relevant cellular nonenzymatic antioxidants [14]....
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Cites background from "Oxidative stress in Alzheimer's dis..."
...…AChE responds to various insults including oxidative stress, an important event that has been related to the pathogenesis and progression of a variety of CNS disorders, such as stroke (Ozkul et al., 2007), Alzheimer's diseases (Chauhan and Chauhan, 2006) and diabetes mellitus (Kuhad et al., 2008)....
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..., 2007), Alzheimer's diseases (Chauhan and Chauhan, 2006) and diabetes mellitus (Kuhad et al....
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References
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"Oxidative stress in Alzheimer's dis..." refers background in this paper
...[13] J....
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...Butterfield, Amyloid beta-peptide [1-42]-associated free radical-induced oxidative stress and neurodegeneration in Alzheimer’s disease brain: mechanisms and consequences, Curr....
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...F d W r p r A is produced by the proteolytic cleavage of membranessociated -amyloid precursor protein (APP) [13]....
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4,327 citations
"Oxidative stress in Alzheimer's dis..." refers background in this paper
...[3] C....
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...AD pathology is often observed in adult DS patients [3]....
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...The major amyloid protein in AD and also in adult Down syndrome (DS) is amyloid beta-protein (A ) of 39–43 amino acids [3]....
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...Butterfield, Amyloid beta-peptide [1-42]-associated free radical-induced oxidative stress and neurodegeneration in Alzheimer’s disease brain: mechanisms and consequences, Curr....
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3,879 citations
3,825 citations